2021
Down-regulation of GP130 signaling sensitizes bladder cancer to cisplatin by impairing Ku70 DNA repair signaling and promoting apoptosis
He S, Li G, Schätzlein AG, Humphrey PA, Weiss RM, Uchegbu IF, Martin DT. Down-regulation of GP130 signaling sensitizes bladder cancer to cisplatin by impairing Ku70 DNA repair signaling and promoting apoptosis. Cellular Signalling 2021, 81: 109931. PMID: 33529758, DOI: 10.1016/j.cellsig.2021.109931.Peer-Reviewed Original ResearchConceptsBladder cancer cellsCancer cellsHuman bladder cancer specimensCisplatin-based chemotherapyBladder cancer treatmentBladder cancer specimensChemoresistant bladder cancer cellsBreast cancer cellsCell viabilityBladder cancerCancer specimensSmall molecule inhibitorsLevels of Ku70Cancer treatmentKu70 expression
2014
Blocking of the ATP sensitive potassium channel ameliorates the ischaemia‐reperfusion injury in the rat testis
Shimizu S, Oikawa R, Tsounapi P, Inoue K, Shimizu T, Tanaka K, Martin D, Honda M, Sejima T, Tomita S, Saito M. Blocking of the ATP sensitive potassium channel ameliorates the ischaemia‐reperfusion injury in the rat testis. Andrology 2014, 2: 458-465. PMID: 24604784, DOI: 10.1111/j.2047-2927.2014.00199.x.Peer-Reviewed Original ResearchConceptsTesticular IR injuryKATP channel blocker glibenclamideIschaemia-reperfusion injuryChannel blocker glibenclamideKATP channel blockerIR injuryKATP channel openerChannel openersTesticular ischaemiaBlocker glibenclamideChannel blockersEffective drugsSelective mitochondrial KATP channel blockerEight-week-old male SpragueKATP channel opener cromakalimATP-sensitive potassium channel openerSensitive potassium channel openerMitochondrial KATP channel blockerATP-sensitive potassium channelsAdministration of glibenclamideInduction of ischaemiaKATP channel opener diazoxideChannel opener cromakalimSensitive potassium channelsPotassium channel openers