2013
Nanoparticles for urothelium penetration and delivery of the histone deacetylase inhibitor belinostat for treatment of bladder cancer
Martin DT, Hoimes CJ, Kaimakliotis HZ, Cheng CJ, Zhang K, Liu J, Wheeler MA, Kelly WK, Tew GN, Saltzman WM, Weiss RM. Nanoparticles for urothelium penetration and delivery of the histone deacetylase inhibitor belinostat for treatment of bladder cancer. Nanomedicine Nanotechnology Biology And Medicine 2013, 9: 1124-1134. PMID: 23764660, PMCID: PMC3815967, DOI: 10.1016/j.nano.2013.05.017.Peer-Reviewed Original ResearchConceptsHistone deacetylase inhibitor belinostatBladder cancerBladder permeability barrierNon-invasive bladder cancerCultured bladder cancer cellsBladder cancer cellsChemotherapy efficacyIntravesical drug deliveryXenograft tumorsMouse bladderMouse modelConvincing dataHuman ureterBelinostatCancerCancer cellsLower IC50TumorsAcetyl-H4Tissue penetrationCLINICAL EDITORIntracellular uptakeDeliveryCellsPatients
2007
Tubedown Expression Correlates with the Differentiation Status and Aggressiveness of Neuroblastic Tumors
Martin DT, Gendron RL, Jarzembowski JA, Perry A, Collins MH, Pushpanathan C, Miskiewicz E, Castle VP, Paradis H. Tubedown Expression Correlates with the Differentiation Status and Aggressiveness of Neuroblastic Tumors. Clinical Cancer Research 2007, 13: 1480-1487. PMID: 17332292, DOI: 10.1158/1078-0432.ccr-06-1716.Peer-Reviewed Original ResearchConceptsNeuroblastic tumorsPrognostic factorsDifferentiation statusIndependent prognostic factorRisk group stratificationHigh-risk groupNew prognostic factorsNormal adrenal tissueRetinoic acid-induced neuronal differentiationNeuroblastoma cell linesUnfavorable histopathologyPoor outcomeNeuroblastoma patientsAdrenal tissueGroup stratificationTumor subsetsAdvanced stageDifferentiation responseFavorable histopathologyTumorsNeuroblastoma cellsExpression correlatesWestern blotWestern blottingMonoclonal antibodies