2024
Symptom assessment and angina classification of patients with ischemia and nonobstructive coronary arteries undergoing invasive coronary function testing: from the DISCOVER INOCA multicenter registry
Shah S, Tremmel J, Henry T, Smilowitz N, Prasad M, Kobayashi Y, Henry G, Samady H, Samuels B, Lerman A, Moses J, Zhang Z, Tirziu D, Chamie D, Lansky A. Symptom assessment and angina classification of patients with ischemia and nonobstructive coronary arteries undergoing invasive coronary function testing: from the DISCOVER INOCA multicenter registry. European Heart Journal 2024, 45: ehae666.1617. DOI: 10.1093/eurheartj/ehae666.1617.Peer-Reviewed Original ResearchCoronary function testingCoronary microvascular dysfunctionInvasive coronary function testingNonobstructive coronary arteriesCanadian Cardiovascular SocietyVasospastic anginaAngina classificationCoronary flow reserveMulticenter registryClassification of patientsChest painCoronary angiographyFemale patientsCMD groupFunction testsAverage coronary flow reserveCoronary arteryPost-procedure diagnosesVasospastic angina groupPatients 4%Coronary vasomotor disordersSymptomatic myocardial bridgingRest symptomsShortness of breathDiagnostic phenotypesLong-term outcomes of ischaemia with no obstructive coronary artery disease (INOCA): a systematic review and meta-analysis
Odanović N, Schwann A, Zhang Z, Kapadia S, Kunnirickal S, Parise H, Tirziu D, Ilic I, Lansky A, Pietras C, Shah S. Long-term outcomes of ischaemia with no obstructive coronary artery disease (INOCA): a systematic review and meta-analysis. Open Heart 2024, 11: e002852. PMID: 39353703, PMCID: PMC11448144, DOI: 10.1136/openhrt-2024-002852.Peer-Reviewed Original ResearchConceptsCoronary Vasomotor Disorders International Study GroupRate of MACEReduced coronary flow reserveCoronary flow reservePrognosis of patientsVasospastic anginaPatient yearsMyocardial infarctionPrimary outcomeIncidence of primary outcomeLong-term prognosis of patientsSystematic reviewMeta-analysisLong-term prognosisInternational Study GroupAdverse cardiovascular eventsLong-term outcomesImaging stress testsMeta-analysis of studiesRandom-effects modelWeb of ScienceINOCACardiovascular eventsFollow-upVasomotor disordersTCT-677 Evaluating Ischemia With Nonobstructive Coronary Arteries Using Invasive Coronary Function Testing: Insights From the DISCOVER INOCA Multicenter Registry
Shah S, Tremmel J, Smilowitz N, Prasad M, Kobayashi Y, Henry T, Henry G, Samady H, Samuels B, Lerman A, Moses J, Pietras C, Zhang Z, Tirziu D, Parise H, Cristea E, Chamie D, Henrici K, Latif N, Cigarroa N, Lansky A. TCT-677 Evaluating Ischemia With Nonobstructive Coronary Arteries Using Invasive Coronary Function Testing: Insights From the DISCOVER INOCA Multicenter Registry. Journal Of The American College Of Cardiology 2024, 84: b260. DOI: 10.1016/j.jacc.2024.09.802.Peer-Reviewed Original ResearchTCT-674 Diagnosis of Coronary Microvascular Dysfunction With Invasive Coronary Function Testing: Insights From the DISCOVER INOCA Multicenter Registry
Shah S, Samuels B, Tremmel J, Henry T, Smilowitz N, Prasad M, Kobayashi Y, Henry G, Samady H, Lerman A, Moses J, Pietras C, Zhang Z, Tirziu D, Parise H, Cristea E, Chamie D, Henrici K, Latif N, Cigarroa N, Lansky A. TCT-674 Diagnosis of Coronary Microvascular Dysfunction With Invasive Coronary Function Testing: Insights From the DISCOVER INOCA Multicenter Registry. Journal Of The American College Of Cardiology 2024, 84: b258-b259. DOI: 10.1016/j.jacc.2024.09.799.Peer-Reviewed Original ResearchTCT-671 Evaluation of Coronary Tortuosity in Patients With Ischemia and No Coronary Artery Disease: Insights From the DISCOVER INOCA Multicenter Registry
Sohal S, Cristea E, Higney J, Williams O, Ohadi L, Samuels B, Tremmel J, Henry T, Smilowitz N, Prasad M, Kobayashi Y, Henry G, Samady H, Lerman A, Moses J, Pietras C, Zhang Z, Tirziu D, Parise H, Chamie D, Henrici K, Latif N, Lansky A, Shah S. TCT-671 Evaluation of Coronary Tortuosity in Patients With Ischemia and No Coronary Artery Disease: Insights From the DISCOVER INOCA Multicenter Registry. Journal Of The American College Of Cardiology 2024, 84: b258. DOI: 10.1016/j.jacc.2024.09.796.Peer-Reviewed Original ResearchClinical Significance of Diffusion-Weighted Brain MRI Lesions After TAVR Results of a Patient-Level Pooled Analysis
Lansky A, Grubman D, Dwyer M, Zivadinov R, Parise H, Moses J, Shah T, Pietras C, Tirziu D, Gambone L, Leon M, Nazif T, Messé S. Clinical Significance of Diffusion-Weighted Brain MRI Lesions After TAVR Results of a Patient-Level Pooled Analysis. Journal Of The American College Of Cardiology 2024, 84: 712-722. PMID: 39142725, DOI: 10.1016/j.jacc.2024.05.055.Peer-Reviewed Original ResearchConceptsTranscatheter aortic valve replacementClinical ischemic strokeAcute brain infarctionDW-MRIReceiver operating characteristicIschemic strokeTranscatheter aortic valve replacement resultBrain infarctionPatient-level pooled analysisC-statisticBrain MRI lesionsAcute ischemic brain injuryDiffusion-weighted magnetic resonance imagingAortic valve replacementIndividual lesion volumesCore laboratory analysisIschemic brain injuryPredicting ischemic strokeMagnetic resonance imagingStroke Prevention TrialMRI lesionsValve replacementDW-MRI acquisitionsPatient-level dataPooled analysisDetermining the Cause of Coronary Vasomotor Disorders in Patients With Ischemia and Nonobstructive Coronary Arteries: Design and Rationale of the DISCOVER INOCA Prospective, Multicenter Registry
Shah S, Tremmel J, Henry T, Smilowitz N, Prasad M, Kobayashi Y, Henry G, Samady H, Samuels B, Lerman A, Moses J, Pietras C, Zhang Z, Tirziu D, Parise H, Cristea E, Chamié D, Grubman D, Henrici K, Matmusaeva E, Latif N, Cigarroa N, Lansky A. Determining the Cause of Coronary Vasomotor Disorders in Patients With Ischemia and Nonobstructive Coronary Arteries: Design and Rationale of the DISCOVER INOCA Prospective, Multicenter Registry. Journal Of The Society For Cardiovascular Angiography & Interventions 2024, 3: 102046. PMID: 39132594, PMCID: PMC11308755, DOI: 10.1016/j.jscai.2024.102046.Peer-Reviewed Original ResearchCoronary function testingObstructive coronary artery diseaseCoronary artery diseaseNonobstructive coronary arteriesLong-term outcomesFollow-upVasomotor disordersEnd pointsComposite of cardiovascular deathCoronary arteryLong-term follow-upCoronary microvascular dysfunctionDiagnostic coronary angiographyCardiovascular adverse eventsAdverse cardiovascular eventsCoronary vasomotor disordersOptical coherence tomographySymptomatic myocardial bridgingShort-term end pointsAtherosclerotic plaque burdenIschemic heart diseaseLong-term end pointsINOCA patientsAcetylcholine provocationPatient-reported outcome measuresSAFETY AND EFFICACY OF ENDOVASCULAR TREATMENT MODALITIES FOR BELOW-THE-KNEE PERIPHERAL ARTERIAL DISEASE: A SYSTEMATIC REVIEW AND NETWORK META-ANALYSIS
Tirziu D, Saleh A, Huang H, Akhlaghi N, Breen T, Parikh S, Rosenfield K, Armstrong E, Geraghty P, Brodmann M, Adams G, Snyder D, Zilinyi R, Altin S, Parise H, Lansky A. SAFETY AND EFFICACY OF ENDOVASCULAR TREATMENT MODALITIES FOR BELOW-THE-KNEE PERIPHERAL ARTERIAL DISEASE: A SYSTEMATIC REVIEW AND NETWORK META-ANALYSIS. Journal Of The American College Of Cardiology 2024, 83: 843. DOI: 10.1016/s0735-1097(24)02833-x.Peer-Reviewed Original Research
2023
Impact of sex on Transcatheter aortic valve replacement outcomes: Results of a single-center study
See C, Wang Y, Yang Y, Tirziu D, Papoutsidakis N, Francese D, Kaple R, Cleman M, Lansky A, Forrest J. Impact of sex on Transcatheter aortic valve replacement outcomes: Results of a single-center study. International Journal Of Cardiology 2023, 398: 131643. PMID: 38065329, DOI: 10.1016/j.ijcard.2023.131643.Peer-Reviewed Original ResearchNew-generation valvesTranscatheter Aortic Valve Replacement OutcomesImpact of sexTAVR outcomesArtery diseaseYale-New Haven HospitalSTS mortality scorePeripheral artery diseaseSingle-center studyCoronary artery diseaseKaplan-Meier curvesLog-rank testNew Haven HospitalSex-based disparitiesSignificant differencesCardiovascular comorbiditiesSAPIEN 3Transfemoral accessSAPIEN XTConsecutive patientsCox modelingMortality scoreEvolut RFemale sexEvolut PROPercutaneous Transluminal Angioplasty for Infrapopliteal Chronic Limb-Threatening Ischemia: A Systematic Review and Meta-analysis of Primary Patency and Binary Restenosis Rates.
Snyder D, Zilinyi R, Pruthi S, George S, Tirziu D, Lansky A, Mintz A, Sethi S, Parikh S. Percutaneous Transluminal Angioplasty for Infrapopliteal Chronic Limb-Threatening Ischemia: A Systematic Review and Meta-analysis of Primary Patency and Binary Restenosis Rates. Journal Of Endovascular Therapy 2023, 15266028231212133. PMID: 38008929, DOI: 10.1177/15266028231212133.Peer-Reviewed Original ResearchChronic limb-threatening ischemiaPercutaneous transluminal angioplastyBinary restenosis ratePrimary patencyPrimary patency rateBinary restenosisTransluminal angioplastyRestenosis rateFuture RCTsPatency ratesTrial dataChronic limb threatening ischemiaLimb threatening ischemiaLimb-threatening ischemiaRandom-effects modelMeta-analysis demonstrateIntermittent claudicationEndovascular therapyCochrane CENTRALPower calculationMeta-analysis estimatesControl armPatencyRCTsSystematic reviewImpact and Implications of Neurocognitive Dysfunction in the Management of Ischemic Heart Failure
Tirziu D, Kołodziejczak M, Grubman D, Carrión C, Driskell L, Ahmad Y, Petrie M, Omerovic E, Redfors B, Fremes S, Browndyke J, Lansky A. Impact and Implications of Neurocognitive Dysfunction in the Management of Ischemic Heart Failure. Journal Of The Society For Cardiovascular Angiography & Interventions 2023, 2: 101198. PMID: 39131066, PMCID: PMC11308118, DOI: 10.1016/j.jscai.2023.101198.Peer-Reviewed Original ResearchIschemic heart failureHeart failureNeurocognitive dysfunctionCognitive impairmentCoronary Artery Bypass GraftingArtery Bypass GraftingChronic cerebral hypoperfusionCoronary artery bypassPercutaneous coronary interventionPoor cognitive functionArtery bypassBypass GraftingCardiovascular outcomesCerebral hypoperfusionCoronary revascularizationCerebral hypoxiaCoronary interventionNeurologic injuryCardiac outputWorse outcomesBrain damageBrain injuryPatient outcomesInvasive approachPatient managementTCT-627 Binary Restenosis Rates Following Percutaneous Transluminal Angioplasty for Below-the-Knee Chronic Limb-Threatening Ischemia: A Meta-Analysis of Randomized Controlled Trial Data
Snyder D, Zilinyi R, Pruthi S, George S, Tirziu D, Lansky A, Mintz A, Sethi S, Parikh S. TCT-627 Binary Restenosis Rates Following Percutaneous Transluminal Angioplasty for Below-the-Knee Chronic Limb-Threatening Ischemia: A Meta-Analysis of Randomized Controlled Trial Data. Journal Of The American College Of Cardiology 2023, 82: b252-b253. DOI: 10.1016/j.jacc.2023.09.638.Peer-Reviewed Original ResearchSupervised Exercise Therapy Versus Percutaneous Transluminal Angioplasty for Claudication by Level of Disease: A Systematic Review and Meta-Analysis
Kapadia S, Huang H, Parise H, Ismayl M, Ahmed Z, Tirziu D, Altin S. Supervised Exercise Therapy Versus Percutaneous Transluminal Angioplasty for Claudication by Level of Disease: A Systematic Review and Meta-Analysis. The American Journal Of Cardiology 2023, 205: 403-405. PMID: 37659260, DOI: 10.1016/j.amjcard.2023.08.044.Peer-Reviewed Original ResearchChocolate Touch Versus Lutonix Drug-Coated Balloon for Femoropopliteal Lesions in Diabetes: The Chocolate Touch Study.
Böhme T, Zeller T, Shishehbor M, Werner M, Brodmann M, Parise H, Holden A, Lichtenberg M, Parikh S, Kashyap V, Pietras C, Tirziu D, Beschorner U, Krishnan P, Niazi K, Wali A, Lansky A. Chocolate Touch Versus Lutonix Drug-Coated Balloon for Femoropopliteal Lesions in Diabetes: The Chocolate Touch Study. Journal Of Endovascular Therapy 2023, 15266028231179589. PMID: 37314243, DOI: 10.1177/15266028231179589.Peer-Reviewed Original ResearchLutonix drug-coated balloonDrug-coated balloonsPrimary safety endpointDM statusFemoropopliteal diseaseDiabetes mellitusSafety endpointFemoropopliteal lesionsSimilar safetyHigh-risk patient populationFemoropopliteal artery lesionsIschemic rest painNon-DM patientsSymptomatic femoropopliteal lesionsPrimary efficacy endpointMajor adverse eventsTherapy of choiceDrug-Coated BalloonMajor amputationRest painEfficacy endpointPrimary patencyAdverse eventsArtery lesionsDiabetes statusImpact of New‐Onset Conduction Disturbances following Transcatheter Aortic Valve Replacement on Outcomes: A Single‐Center Study
See C, Wang Y, Huang H, Parise H, Yang Y, Tirziu D, Francese D, Papoutsidakis N, Bader E, Kaple R, Cleman M, Lansky A, Forrest J. Impact of New‐Onset Conduction Disturbances following Transcatheter Aortic Valve Replacement on Outcomes: A Single‐Center Study. Journal Of Interventional Cardiology 2023, 2023: 5390338. PMID: 37292113, PMCID: PMC10247319, DOI: 10.1155/2023/5390338.Peer-Reviewed Original ResearchConceptsTranscatheter aortic valve replacementNew-onset conduction disturbancesAortic valve replacementPersistent conduction disturbancesConduction disturbancesValve replacementSurgical aortic valve replacementSingle-center retrospective analysisYale-New Haven HospitalSingle-center studyCause mortality ratesCause mortality riskLong-term outcomesNew Haven HospitalPeriprocedural factorsAortic stenosisConsecutive patientsTAVR proceduresTerm outcomesRetrospective analysisMortality riskMortality ratePatientsOutcomesPatient's ECGCerebral Embolic Risk in Coronary and Structural Heart Interventions: Clinical Evidence
Tirziu D, Huang H, Parise H, Pietras C, Moses J, Messé S, Lansky A. Cerebral Embolic Risk in Coronary and Structural Heart Interventions: Clinical Evidence. Journal Of The Society For Cardiovascular Angiography & Interventions 2023, 2: 100631. PMID: 39130705, PMCID: PMC11307836, DOI: 10.1016/j.jscai.2023.100631.Peer-Reviewed Original ResearchStructural heart interventionsHeart interventionsCardiac proceduresBrain injuryLong-term neurocognitive sequelaeTranscatheter aortic valve replacement (TAVR) proceduresAortic valve replacement proceduresCerebral embolic riskIatrogenic brain injuryIschemic brain injuryRisk of thromboembolismCoronary artery diseaseEmbolic protection devicesNumber of patientsValve replacement proceduresPercutaneous transcatheter interventionsLikelihood of disabilitySymptomatic strokeCerebral embolismCerebral embolizationEmbolic riskAcute strokeNeurologic injuryArtery diseaseIschemic infarctionAntiplatelet Strategies Following PCI: A Review of Trials Informing Current and Future Therapies
Thomas A, Gitto M, Shah S, Saito Y, Tirziu D, Chieffo A, Stefanini G, Lansky A. Antiplatelet Strategies Following PCI: A Review of Trials Informing Current and Future Therapies. Journal Of The Society For Cardiovascular Angiography & Interventions 2023, 2: 100607. PMID: 39130709, PMCID: PMC11307978, DOI: 10.1016/j.jscai.2023.100607.Peer-Reviewed Original ResearchDual antiplatelet therapyAntiplatelet regimensPatient-specific risk profileShorter DAPT durationDuration of therapyPercutaneous coronary interventionDAPT strategyIschemic riskAntiplatelet therapyDAPT durationAntiplatelet strategiesCoronary interventionOngoing trialsMajor trialsRecent trialsPractice guidelinesFuture therapiesRisk profileTherapyStent technologyTrialsRegimensNumber of trialsSignificant reductionSignificant changesSUPERVISED EXERCISE THERAPY VERSUS PERCUTANEOUS TRANSLUMINAL ANGIOPLASTY FOR CLAUDICATION BY LEVEL OF DISEASE: A SYSTEMATIC REVIEW AND META-ANALYSIS
Kapadia S, Huang H, Tirziu D, Ahmed Z, Altin S. SUPERVISED EXERCISE THERAPY VERSUS PERCUTANEOUS TRANSLUMINAL ANGIOPLASTY FOR CLAUDICATION BY LEVEL OF DISEASE: A SYSTEMATIC REVIEW AND META-ANALYSIS. Journal Of The American College Of Cardiology 2023, 81: 2050. DOI: 10.1016/s0735-1097(23)02494-4.Peer-Reviewed Original Research
2022
Impella Versus Intra-Aortic Balloon Pump for High-Risk PCI: A Propensity-Adjusted Large-Scale Claims Dataset Analysis
Lansky AJ, Tirziu D, Moses JW, Pietras C, Ohman EM, O'Neill WW, Ekono MM, Grines CL, Parise H. Impella Versus Intra-Aortic Balloon Pump for High-Risk PCI: A Propensity-Adjusted Large-Scale Claims Dataset Analysis. The American Journal Of Cardiology 2022, 185: 29-36. PMID: 36210212, DOI: 10.1016/j.amjcard.2022.08.032.Peer-Reviewed Original ResearchConceptsHigh-risk percutaneous coronary interventionIntra-aortic balloon pumpPercutaneous coronary interventionAcute kidney injuryCardiogenic shockMyocardial infarctionIABP supportKidney injuryBalloon pumpImproved survivalPropensity adjustmentAcute ST-elevation myocardial infarctionST-elevation myocardial infarctionIndex hospitalization lengthLess myocardial infarctionPremier Healthcare DatabaseHospital myocardial infarctionPropensity-adjusted analysisMechanical circulatory supportMechanical support devicesImpella useHospital survivalIndex hospitalizationCoronary interventionReal-world practiceRandomized Trial of Chocolate Touch Compared With Lutonix Drug-Coated Balloon in Femoropopliteal Lesions (Chocolate Touch Study)
Shishehbor MH, Zeller T, Werner M, Brodmann M, Parise H, Holden A, Lichtenberg M, Parikh SA, Kashyap VS, Pietras C, Tirziu D, Ardakani S, Beschorner U, Krishnan P, Niazi KA, Wali AU, Lansky AJ. Randomized Trial of Chocolate Touch Compared With Lutonix Drug-Coated Balloon in Femoropopliteal Lesions (Chocolate Touch Study). Circulation 2022, 145: 1645-1654. PMID: 35377157, DOI: 10.1161/circulationaha.122.059646.Peer-Reviewed Original ResearchConceptsLutonix drug-coated balloonDrug-coated balloonsEnd pointPrimary efficacy end pointPrimary safety end pointIndependent clinical events committeeIschemic rest painPrimary efficacy rateEfficacy end pointPrimary end pointSafety end pointClinical events committeeMajor adverse eventsRate of restenosisDrug-Coated BalloonNoninferiority end pointSafety event rateAverage lesion lengthMajor amputationPopliteal diseaseRest painBailout stentingEfficacy ratePrimary patencyAdverse events