2006
Chondroitin sulfate-modified LDL induces increased cholesteryl ester synthesis and down-regulation of LDL receptors in smooth muscle cells and macrophages
Tircol M, Tirziu D, Simionescu M. Chondroitin sulfate-modified LDL induces increased cholesteryl ester synthesis and down-regulation of LDL receptors in smooth muscle cells and macrophages. Open Life Sciences 2006, 1: 150-166. DOI: 10.2478/s11535-006-0010-x.Peer-Reviewed Original ResearchSmooth muscle cellsLipid accumulationMuscle cellsHuman aortic smooth muscle cellsCultured smooth muscle cellsAortic smooth muscle cellsGene expressionLysosomal degradationLDL receptorCellular degradationMatrix proteinsAcidic compartmentsCellular uptakeLysosomal compartmentCell typesFluorescence microscopyLDL inducesUndegraded formCholesterol ester synthesisRT-PCRCholesteryl ester synthesisNative LDLAccumulationRegulationRegulation of LDL
1995
Intimal thickenings of human aorta contain modified reassembled lipoproteins
Tîrziu D, Dobrian A, Tasca C, Simionescu M, Simionescu N. Intimal thickenings of human aorta contain modified reassembled lipoproteins. Atherosclerosis 1995, 112: 101-114. PMID: 7772061, DOI: 10.1016/0021-9150(94)05405-8.Peer-Reviewed Original Research