2018
Cardiac Hypertrophy: Signaling and Cellular Crosstalk
Tirziu D. Cardiac Hypertrophy: Signaling and Cellular Crosstalk. 2018 DOI: 10.1016/b978-0-12-801238-3.99834-9.Peer-Reviewed Original ResearchCardiac hypertrophyHypertrophic responseHemodynamic stressMolecular basisPathological hypertrophic responsesCellular crosstalkVariety of stimuliMyocardial infarctionImmune cellsCardiac performanceHypertrophic growthChronic increaseVascular cellsPhysiological stimuliCellular communicationMajor playersCardiac cellsWall stressHypertrophyCellsCrosstalkCardiomyocytesPrimary mechanismSignalingStressCardiac Hypertrophy: Signaling and Cellular Crosstalk
Tirziu D. Cardiac Hypertrophy: Signaling and Cellular Crosstalk. 2018, 434-450. DOI: 10.1016/b978-0-12-809657-4.99834-x.Peer-Reviewed Original ResearchCardiac hypertrophyHypertrophic responseHemodynamic stressMolecular basisPathological hypertrophic responsesCellular crosstalkVariety of stimuliMyocardial infarctionImmune cellsCardiac performanceHypertrophic growthChronic increaseVascular cellsPhysiological stimuliCellular communicationMajor playersCardiac cellsWall stressHypertrophyCellsCrosstalkCardiomyocytesPrimary mechanismSignalingStress
2013
NO triggers RGS4 degradation to coordinate angiogenesis and cardiomyocyte growth
Jaba IM, Zhuang ZW, Li N, Jiang Y, Martin KA, Sinusas AJ, Papademetris X, Simons M, Sessa WC, Young LH, Tirziu D. NO triggers RGS4 degradation to coordinate angiogenesis and cardiomyocyte growth. Journal Of Clinical Investigation 2013, 123: 1718-1731. PMID: 23454748, PMCID: PMC3613910, DOI: 10.1172/jci65112.Peer-Reviewed Original ResearchMeSH KeywordsAdaptation, BiologicalAnimalsCell EnlargementCells, CulturedCoronary VesselsEndothelium, VascularHeart VentriclesMechanistic Target of Rapamycin Complex 1MiceMice, Inbred C57BLMice, TransgenicMultiprotein ComplexesMyocytes, CardiacNeovascularization, PhysiologicNG-Nitroarginine Methyl EsterNitric OxideNitric Oxide SynthasePlacenta Growth FactorPregnancy ProteinsProteinsProteolysisProto-Oncogene Proteins c-aktRatsRats, Sprague-DawleyRGS ProteinsSignal TransductionTOR Serine-Threonine KinasesConceptsCardiomyocyte growthAkt/mTORC1 signalingNovel NO-dependent mechanismProteasomal degradationCoordination of angiogenesisMTORC1 signalingConditional overexpressionMurine cardiac tissueG proteinsTransgenic expressionAkt/Physiological mechanismsMyocyte growthVessel growthGrowth factorTransgenic miceHypertrophic responseAngiogenesisKnockout miceMyocardial hypertrophyExpressionGrowthCardiac hypertrophyNOS inhibitor L-NAMEInduction