2021
Neuroanatomy of the GnRH/Kisspeptin System
Spergel D. Neuroanatomy of the GnRH/Kisspeptin System. Masterclass In Neuroendocrinology 2021, 12: 197-229. DOI: 10.1007/978-3-030-86630-3_8.ChaptersKisspeptin neuronsExtra-hypothalamic areasGonadotropin-releasing hormoneGnRH neuronsGnRH secretionHypothalamic GnRHViral tracingTransgenic miceKisspeptin systemNeuronsGnRHGreen fluorescent proteinAnatomical characterizationNeuroanatomyCurrent bodyDendritic zoneTissue clearingRatsAxonsMiceHormoneSecretionBiomarkers
2019
Modulation of Gonadotropin-Releasing Hormone Neuron Activity and Secretion in Mice by Non-peptide Neurotransmitters, Gasotransmitters, and Gliotransmitters
Spergel DJ. Modulation of Gonadotropin-Releasing Hormone Neuron Activity and Secretion in Mice by Non-peptide Neurotransmitters, Gasotransmitters, and Gliotransmitters. Frontiers In Endocrinology 2019, 10: 329. PMID: 31178828, PMCID: PMC6538683, DOI: 10.3389/fendo.2019.00329.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsGnRH neuron activityGnRH secretionNeuron activityNon-peptide neurotransmittersGnRH neuronsGonadotropin-Releasing Hormone Neuron ActivityMouse GnRH neuronsProstaglandin E2Central regulationAdult miceGliotransmittersMouse studiesNitric oxideSecretionNeurotransmittersDirect modulationMiceNeuronsGasotransmitterFurther explorationGonadotropinModulationActivityGABAPostnatal
2018
Neuropeptidergic modulation of GnRH neuronal activity and GnRH secretion controlling reproduction: insights from recent mouse studies
Spergel DJ. Neuropeptidergic modulation of GnRH neuronal activity and GnRH secretion controlling reproduction: insights from recent mouse studies. Cell And Tissue Research 2018, 375: 179-191. PMID: 30078104, DOI: 10.1007/s00441-018-2893-z.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsGnRH neuronsGnRH secretionGnRH neuronal activityGnRH neuronal firingRecent mouse studiesHormone secretionNeuronal activityNeuronal firingNeuropeptidergic modulationMouse studiesCognate receptorsNeuropeptidesNeuronsSecretionMammalian reproductionReproduction-related processesGonadotropinModulationMiceReceptors
2009
Innervation of Gonadotropin-Releasing Hormone Neurons by Peptidergic Neurons Conveying Circadian or Energy Balance Information in the Mouse
Ward DR, Dear FM, Ward IA, Anderson SI, Spergel DJ, Smith PA, Ebling FJ. Innervation of Gonadotropin-Releasing Hormone Neurons by Peptidergic Neurons Conveying Circadian or Energy Balance Information in the Mouse. PLOS ONE 2009, 4: e5322. PMID: 19390688, PMCID: PMC2669176, DOI: 10.1371/journal.pone.0005322.Peer-Reviewed Original ResearchConceptsGnRH neuronsVasoactive intestinal peptidePeptidergic neuronsGonadotropin-Releasing Hormone NeuronsGnRH secretory systemVIP-IR fibersGonadotropin-releasing hormoneHypothalamic peptide systemsHormone neuronsBasal forebrainIntestinal peptideHypothalamic neuropeptidesPeptidergic fibersReproductive axisTransgenic miceModulatory inputsNeuronsCircadian timing informationPeptidergic signalsMetabolic statusMiceCircadian informationInnervationSignificant proportionPeptide system