2024
Comparable Overall Risk of Neurologic Adverse Events Following Cervicothoracic Interlaminar and Transforaminal Epidural Injections: An Analysis of 1.29 Million Patients.
Seddio A, McNamara K, Gouzoulis M, Jabbouri S, Vasudevan R, Day W, Ratnasamy P, Rubio D, Grauer J. Comparable Overall Risk of Neurologic Adverse Events Following Cervicothoracic Interlaminar and Transforaminal Epidural Injections: An Analysis of 1.29 Million Patients. Spine 2024 PMID: 39394649, DOI: 10.1097/brs.0000000000005181.Peer-Reviewed Original ResearchNeurological adverse eventsAdverse eventsElixhauser Comorbidity IndexNeurological complicationsOdds ratioEpidural spinal injectionsInterlaminar (ILTransforaminal epidural injectionsAssociated with specific complicationsTransforaminal (TFNerve root injuryRisk of complicationsAssociated with higher odds ratiosMultivariate logistic regressionRisk of neurological adverse eventsHigher odds ratioCervical pathologyEpidural hematomaTF injectionSpinal injectionEpidural injectionSpecific complicationsAdult patientsCase reportComorbidity indexP27. Renal transplant patients at increased odds off many perioperative adverse events following lumbar laminotomy/discectomy
Gouzoulis M, Seddio A, Zhu J, Day W, Jabbouri S, Rubio D, Grauer J. P27. Renal transplant patients at increased odds off many perioperative adverse events following lumbar laminotomy/discectomy. The Spine Journal 2024, 24: s76. DOI: 10.1016/j.spinee.2024.06.048.Peer-Reviewed Original ResearchSevere adverse eventsHistory of renal transplantationUrinary tract infectionRenal transplantationAcute kidney injuryAdverse eventsMinor adverse eventsElixhauser Comorbidity IndexIncreased oddsCurrent Procedural TerminologyTract infectionsLumbar discectomyKidney injuryED visitsIncreased odds of acute kidney injuryOdds of acute kidney injuryOdds ratioOdds of ED visitsKaplan-Meier survival curvesDays of follow-upRenal transplant groupRenal transplant patientsIncidence of reoperationRisk of reoperationOdds of sepsisP31. Testosterone replacement therapy associated with increased 90-day postoperative adverse events and 5-year reoperation following lumbar discectomy
Seddio A, Gouzoulis M, Smith-Voudouris J, Rubio D, Day W, Grauer J. P31. Testosterone replacement therapy associated with increased 90-day postoperative adverse events and 5-year reoperation following lumbar discectomy. The Spine Journal 2024, 24: s78. DOI: 10.1016/j.spinee.2024.06.052.Peer-Reviewed Original ResearchTestosterone replacement therapyAcute kidney injuryLumbar discectomyAdverse eventsMale patientsOdds ratioCurrent Procedural TerminologyReoperation ratePostoperative outcomesElixhauser Comorbidity IndexPostoperative recoveryMultivariate analysisSingle-level lumbar discectomyTestosterone replacement therapy patientsMyocardial infarctionOrthopedic surgeryKaplan-Meier survival analysisEmergency departmentLumbar spinal proceduresLog-rank testMonths of surgeryRetrospective cohort studyPostoperative adverse eventsEnhanced postoperative recoveryMinor adverse events35. Comparable risk of adverse events following cervicothoracic interlaminar and transforaminal epidural injections: an analysis of 1.29 million patients
Seddio A, McNamara K, Gouzoulis M, Jabbouri S, Ratnasamy P, Rubio D, Grauer J. 35. Comparable risk of adverse events following cervicothoracic interlaminar and transforaminal epidural injections: an analysis of 1.29 million patients. The Spine Journal 2024, 24: s19. DOI: 10.1016/j.spinee.2024.06.478.Peer-Reviewed Original ResearchAdverse eventsSpinal neurologic deficitsStatistically significant differenceCurrent Procedural TerminologyElixhauser Comorbidity IndexEpidural injectionAdult patientsNeurological deficitsAdverse outcomesMultivariate analysisED visitsIncidence of adverse eventsEpidural spinal injectionsTransforaminal epidural injectionsEmergency departmentTransforaminal (TFRisk of adverse eventsSignificant differenceRetrospective cohort studyMinor adverse eventsSampled adult patientsOutcome measures IncidencePotential adverse eventsSpinal injectionPatient age100. Semaglutide associated with improved postoperative outcomes following single-level posterior lumbar fusion for patients with type II diabetes
Seddio A, Gouzoulis M, Vasudevan R, Dhodapkar M, Jabbouri S, Zhu J, Rubio D, Grauer J. 100. Semaglutide associated with improved postoperative outcomes following single-level posterior lumbar fusion for patients with type II diabetes. The Spine Journal 2024, 24: s52-s53. DOI: 10.1016/j.spinee.2024.06.543.Peer-Reviewed Original ResearchSingle-level posterior lumbar fusionPosterior lumbar fusionSodium-glucose transport protein 2 inhibitorsImpact of semaglutideHospital readmissionPostoperative outcomesElixhauser Comorbidity IndexED visitsT2DM patientsCurrent Procedural TerminologyEmergency departmentLumbar fusionAdverse eventsOdds of hospital readmissionOutcome measures IncidenceRisk of type I errorInferior postoperative outcomesDiagnosis of T2DMMonths of surgeryYear of surgeryRetrospective cohort studyMinor adverse eventsType II diabetes mellitusMatched 1:4Management of diabetesTrends in management of odontoid fractures 2010–2021
Gouzoulis M, Seddio A, Rancu A, Jabbouri S, Moran J, Varthi A, Rubio D, Grauer J. Trends in management of odontoid fractures 2010–2021. North American Spine Society Journal (NASSJ) 2024, 20: 100553. PMID: 39381260, PMCID: PMC11459689, DOI: 10.1016/j.xnsj.2024.100553.Peer-Reviewed Original ResearchOdontoid fracturesSurgical interventionPredictive factorsAdult patientsManagement of odontoid fracturesPosterior stabilizationMethods Adult patientsNon-clinical factorsRate of surgerySampled adult patientsYearly rateAnterior surgeryPosterior surgeryNonoperative careSurgical managementNonsurgical treatmentClinical factorsMale sexPosterior approachMultivariate analysisMedicare insuranceFracture managementSurgeryPatientsMidwest United StatesOne- versus Three-- Level Fusion in Patients Undergoing Multilevel Lumbar Decompression: Relative Perioperative Risks and Five-year Revisions.
Ratnasamy P, Gouzoulis M, Jabbouri S, Rubio D, Grauer J. One- versus Three-- Level Fusion in Patients Undergoing Multilevel Lumbar Decompression: Relative Perioperative Risks and Five-year Revisions. Spine 2024 PMID: 39190416, DOI: 10.1097/brs.0000000000005130.Peer-Reviewed Original ResearchOne-level fusionLumbar decompressionThree-level fusionPostoperative adverse eventsAdverse eventsOdds ratioElixhauser Comorbidity IndexPatient ageFive-year survivalOdds of perioperative complicationsLumbar decompression patientsPerioperative complicationsDecompression patientsPerioperative riskFusion patientsSpinal reoperationLumbar fusionReoperationComorbidity indexMultivariate analysisPatientsClinical interestDecompressionFusion levelsOddsUtilization and timing of surgical intervention for central cord syndrome in the United States
Dhodapkar M, Halperin S, Seddio A, Dahodwala T, Rubio D, Grauer J. Utilization and timing of surgical intervention for central cord syndrome in the United States. European Spine Journal 2024, 33: 3645-3651. PMID: 39103615, DOI: 10.1007/s00586-024-08431-2.Peer-Reviewed Original ResearchCentral cord syndromeSurgical interventionAbsence of bony injuryOperative interventionCord syndromeBony injuriesPredictors of operative managementAbsence of vertebral fracturesTiming of surgical interventionTiming of operative interventionCohort of patientsProportion of patientsDays of diagnosisHigher comorbidity burdenVertebral fracturesSpinal cord injuryMethodsAdult patientsNon-operativelyNonsurgical interventionsMultivariate analysisStudy assessed utilizationComorbidity burdenIncomplete spinal cord injuryPatientsInclusion criteriaRobotic-Assisted Versus Navigation-Assisted Posterior Lumbar Fusion
Gouzoulis M, Seddio A, Winter A, Jabbouri S, Zhu J, Rubio D, Varthi A, Grauer J. Robotic-Assisted Versus Navigation-Assisted Posterior Lumbar Fusion. Spine 2024, 49: 1483-1487. PMID: 38717329, DOI: 10.1097/brs.0000000000005032.Peer-Reviewed Original ResearchPosterior lumbar fusionLumbar fusionAdverse eventsLevel posterior lumbar fusionsCPT codesKaplan-Meier survival analysisRate of reoperationNavigation-assisted surgeryRobotic-assisted casesNavigation-assistedMinor adverse eventsPerioperative adverse eventsMultivariate logistic regressionICD-10 procedure codeRobotic cohortRobotic assistanceSpinal navigationReoperation rateAnterior fusionElixhauser Comorbidity IndexPearlDiver databaseNo significant differenceIncremental advantageAdverse outcomesComorbidity indexCefazolin Alone Versus Cefazolin with Tobramycin or Gentamicin as Intraoperative Antibiotic Prophylaxis for Single-Level Posterior Lumbar Fusion
Dhodapkar M, Jeong S, Halperin S, Rubio D, Li M, Grauer J. Cefazolin Alone Versus Cefazolin with Tobramycin or Gentamicin as Intraoperative Antibiotic Prophylaxis for Single-Level Posterior Lumbar Fusion. JAAOS Global Research And Reviews 2024, 8: e24.00082. PMCID: PMC11068128, DOI: 10.5435/jaaosglobal-d-24-00082.Peer-Reviewed Original ResearchSingle-level posterior lumbar fusionPosterior lumbar fusionSurgical site infectionElixhauser Comorbidity IndexLumbar fusionAntibiotic prophylaxisAdverse outcomesAntibiotic prophylaxis regimenAntibiotic prophylaxis regimensIntraoperative antibiotic prophylaxisRevision ratePerioperative antibiotic prophylaxisPostoperative adverse outcomesPosterior lumbar fusion patientsMultivariate logistic regressionProphylaxis regimensProphylaxis regimenPatient ageSite infectionUnivariate analysisCefazolinComorbidity indexMultivariate analysisAntibiotic subgroupsTraumatic diagnoses
2023
Low Back Pain: Utilization of Urgent Cares Relative to Emergency Departments
Dhodapkar M, Modrak M, Halperin S, Gouzoulis M, Rubio D, Grauer J. Low Back Pain: Utilization of Urgent Cares Relative to Emergency Departments. Spine 2023, 49: 513-517. PMID: 37982595, DOI: 10.1097/brs.0000000000004880.Peer-Reviewed Original ResearchLow back painElixhauser Comorbidity IndexUrgent care centersEmergency departmentUrgent careBack painED visitsED utilizationCare centerAdvanced imagingUrgent care useUrgent care visitsDays of diagnosisSetting of traumaSpinal cord injuryYears of ageComorbidity indexInfectious diagnosisCare visitsLBP patientsMost patientsRecent surgeryAdult patientsPatient ageED patientsComment on: Investigation of the effect of weight loss after laparoscopic sleeve gastrectomy on Cobb angle, waist and back pain: a prospective study
Jabbouri S, Gibbs K, Rubio D. Comment on: Investigation of the effect of weight loss after laparoscopic sleeve gastrectomy on Cobb angle, waist and back pain: a prospective study. Surgery For Obesity And Related Diseases 2023, 19: 1365-1366. PMID: 37953127, DOI: 10.1016/j.soard.2023.10.002.Peer-Reviewed Original ResearchImaging in spinal infections: Current status and future directions
Dhodapkar M, Patel T, Rubio D. Imaging in spinal infections: Current status and future directions. North American Spine Society Journal (NASSJ) 2023, 16: 100275. PMID: 37822347, PMCID: PMC10562850, DOI: 10.1016/j.xnsj.2023.100275.Peer-Reviewed Original ResearchWeight loss makes the difference: perioperative outcomes following posterior lumbar fusion in patients with and without weight loss following bariatric surgery
Dhodapkar M, Halperin S, Joo P, Maloy G, Jeong S, Rubio D, Grauer J. Weight loss makes the difference: perioperative outcomes following posterior lumbar fusion in patients with and without weight loss following bariatric surgery. The Spine Journal 2023, 23: 1506-1511. PMID: 37302416, DOI: 10.1016/j.spinee.2023.06.002.Peer-Reviewed Original ResearchConceptsHistory of BSPosterior lumbar fusionElixhauser Comorbidity IndexMorbid obesityBariatric surgeryAdverse eventsWeight lossReadmission ratesLumbar fusionSingle-level posterior lumbar fusionImpact of BSRetrospective case-control studyPrior bariatric surgeryMinor adverse eventsLevel posterior lumbar fusionTime of surgeryMultivariable logistic regressionCase-control studyHistory of infectionSignificant weight lossMO categoryMorbidly obesityPLF patientsComorbidity indexPerioperative outcomesCommentary on “Clinical relevance of occult infections in spinal pseudarthrosis revision”
Dahodwala T, Rubio D. Commentary on “Clinical relevance of occult infections in spinal pseudarthrosis revision”. North American Spine Society Journal (NASSJ) 2023, 14: 100213. PMID: 37168323, PMCID: PMC10165127, DOI: 10.1016/j.xnsj.2023.100213.Commentaries, Editorials and LettersIncidental Durotomy After Posterior Lumbar Decompression Surgery Associated With Increased Risk for Venous Thromboembolism
Gouzoulis M, Joo P, Caruana D, Kammien A, Rubio D, Grauer J. Incidental Durotomy After Posterior Lumbar Decompression Surgery Associated With Increased Risk for Venous Thromboembolism. Journal Of The American Academy Of Orthopaedic Surgeons 2023, 31: e445-e450. PMID: 36727948, DOI: 10.5435/jaaos-d-22-00917.Peer-Reviewed Original ResearchConceptsLumbar decompression surgeryPosterior lumbar decompression surgeryRisk of VTEVenous thromboembolismIncidental durotomyDecompression surgeryMultivariate analysisOdds of VTETiming of VTEMore VTEDecompression patientsDurotomy groupPatient demographicsPulmonary embolismAdult patientsDegenerative etiologyBed restLumbar laminectomyPatient recoveryUnivariate analysisSpinal surgeryAdministrative codingDurotomySurgeryPatients
2022
Postoperative spine surgical site infections: high rate of failure of one-stage irrigation and debridement
Dhodapkar M, Galivanche A, Halperin S, Elaydi A, Rubio D, Grauer J. Postoperative spine surgical site infections: high rate of failure of one-stage irrigation and debridement. The Spine Journal 2022, 23: 484-491. PMID: 36549456, DOI: 10.1016/j.spinee.2022.12.005.Peer-Reviewed Original ResearchConceptsSurgical site infectionElective spine surgerySpine surgeryInitial managementRate of SSIInfection characteristicsSpine surgical site infectionPostoperative surgical site infectionRetrospective case-control studyPresence of bacteremiaRisk stratification toolCase-control studySingle academic institutionTimes greater oddsDevastating complicationSite infectionMultivariable analysisStratification toolSurgical managementSurgical variablesIndex procedureSurgical interventionRisk factorsInclusion criteriaLarge cohortCorrelation of Patient Reported Satisfaction With Adverse Events Following Elective Posterior Lumbar Fusion Surgery: A Single Institution Analysis
Mercier MR, Galivanche AR, McLean R, Kammien AJ, Toombs CS, Rubio DR, Varthi AG, Grauer JN. Correlation of Patient Reported Satisfaction With Adverse Events Following Elective Posterior Lumbar Fusion Surgery: A Single Institution Analysis. North American Spine Society Journal (NASSJ) 2022, 12: 100160. PMID: 36118954, PMCID: PMC9478916, DOI: 10.1016/j.xnsj.2022.100160.Peer-Reviewed Original ResearchPosterior lumbar fusion surgeryLumbar fusion surgeryAdverse eventsHCAHPS surveyPLF surgeryFusion surgerySelf-reported patient satisfactionPostoperative adverse eventsRetrospective cohort analysisPost-discharge careSingle-institution analysisHospital Consumer AssessmentPatient satisfaction metricsCorrelation of patientsHCAHPS survey dataTop-box responsesPLF patientsSurvey response ratePatient satisfactionSingle institutionHospital experiencePatients' perceptionsHospital careCohort analysisPatientsSevere contracture in the lower extremity resulting from an osteoid osteoma of the lumbar spine in close proximity to neural elements in an adolescent: a case report.
Clohisy JCF, Rubio DR, Gupta MC. Severe contracture in the lower extremity resulting from an osteoid osteoma of the lumbar spine in close proximity to neural elements in an adolescent: a case report. Spine Deformity 2022, 10: 727-731. PMID: 34988926, DOI: 10.1007/s43390-021-00449-6.Peer-Reviewed Case Reports and Technical NotesSpine-specific skeletal related events and mortality in non-small cell lung cancer patients: a single-institution analysis.
Adogwa O, Rubio DR, Buchowski JM, D'Souza A, Shlykov MA, Jennings JW. Spine-specific skeletal related events and mortality in non-small cell lung cancer patients: a single-institution analysis. Journal Of Neurosurgery. Spine 2022, 36: 125-132. PMID: 33254136, DOI: 10.3171/2020.7.SPINE20829.Peer-Reviewed Original Research