2024
P31. Testosterone replacement therapy associated with increased 90-day postoperative adverse events and 5-year reoperation following lumbar discectomy
Seddio A, Gouzoulis M, Smith-Voudouris J, Rubio D, Day W, Grauer J. P31. Testosterone replacement therapy associated with increased 90-day postoperative adverse events and 5-year reoperation following lumbar discectomy. The Spine Journal 2024, 24: s78. DOI: 10.1016/j.spinee.2024.06.052.Peer-Reviewed Original ResearchTestosterone replacement therapyAcute kidney injuryLumbar discectomyAdverse eventsMale patientsOdds ratioCurrent Procedural TerminologyReoperation ratePostoperative outcomesElixhauser Comorbidity IndexPostoperative recoveryMultivariate analysisSingle-level lumbar discectomyTestosterone replacement therapy patientsMyocardial infarctionOrthopedic surgeryKaplan-Meier survival analysisEmergency departmentLumbar spinal proceduresLog-rank testMonths of surgeryRetrospective cohort studyPostoperative adverse eventsEnhanced postoperative recoveryMinor adverse events35. Comparable risk of adverse events following cervicothoracic interlaminar and transforaminal epidural injections: an analysis of 1.29 million patients
Seddio A, McNamara K, Gouzoulis M, Jabbouri S, Ratnasamy P, Rubio D, Grauer J. 35. Comparable risk of adverse events following cervicothoracic interlaminar and transforaminal epidural injections: an analysis of 1.29 million patients. The Spine Journal 2024, 24: s19. DOI: 10.1016/j.spinee.2024.06.478.Peer-Reviewed Original ResearchAdverse eventsSpinal neurologic deficitsStatistically significant differenceCurrent Procedural TerminologyElixhauser Comorbidity IndexEpidural injectionAdult patientsNeurological deficitsAdverse outcomesMultivariate analysisED visitsIncidence of adverse eventsEpidural spinal injectionsTransforaminal epidural injectionsEmergency departmentTransforaminal (TFRisk of adverse eventsSignificant differenceRetrospective cohort studyMinor adverse eventsSampled adult patientsOutcome measures IncidencePotential adverse eventsSpinal injectionPatient ageTrends in management of odontoid fractures 2010–2021
Gouzoulis M, Seddio A, Rancu A, Jabbouri S, Moran J, Varthi A, Rubio D, Grauer J. Trends in management of odontoid fractures 2010–2021. North American Spine Society Journal (NASSJ) 2024, 20: 100553. PMID: 39381260, PMCID: PMC11459689, DOI: 10.1016/j.xnsj.2024.100553.Peer-Reviewed Original ResearchOdontoid fracturesSurgical interventionPredictive factorsAdult patientsManagement of odontoid fracturesPosterior stabilizationMethods Adult patientsNon-clinical factorsRate of surgerySampled adult patientsYearly rateAnterior surgeryPosterior surgeryNonoperative careSurgical managementNonsurgical treatmentClinical factorsMale sexPosterior approachMultivariate analysisMedicare insuranceFracture managementSurgeryPatientsMidwest United StatesOne- versus Three-- Level Fusion in Patients Undergoing Multilevel Lumbar Decompression: Relative Perioperative Risks and Five-year Revisions.
Ratnasamy P, Gouzoulis M, Jabbouri S, Rubio D, Grauer J. One- versus Three-- Level Fusion in Patients Undergoing Multilevel Lumbar Decompression: Relative Perioperative Risks and Five-year Revisions. Spine 2024 PMID: 39190416, DOI: 10.1097/brs.0000000000005130.Peer-Reviewed Original ResearchOne-level fusionLumbar decompressionThree-level fusionPostoperative adverse eventsAdverse eventsOdds ratioElixhauser Comorbidity IndexPatient ageFive-year survivalOdds of perioperative complicationsLumbar decompression patientsPerioperative complicationsDecompression patientsPerioperative riskFusion patientsSpinal reoperationLumbar fusionReoperationComorbidity indexMultivariate analysisPatientsClinical interestDecompressionFusion levelsOddsUtilization and timing of surgical intervention for central cord syndrome in the United States
Dhodapkar M, Halperin S, Seddio A, Dahodwala T, Rubio D, Grauer J. Utilization and timing of surgical intervention for central cord syndrome in the United States. European Spine Journal 2024, 33: 3645-3651. PMID: 39103615, DOI: 10.1007/s00586-024-08431-2.Peer-Reviewed Original ResearchCentral cord syndromeSurgical interventionAbsence of bony injuryOperative interventionCord syndromeBony injuriesPredictors of operative managementAbsence of vertebral fracturesTiming of surgical interventionTiming of operative interventionCohort of patientsProportion of patientsDays of diagnosisHigher comorbidity burdenVertebral fracturesSpinal cord injuryMethodsAdult patientsNon-operativelyNonsurgical interventionsMultivariate analysisStudy assessed utilizationComorbidity burdenIncomplete spinal cord injuryPatientsInclusion criteriaCefazolin Alone Versus Cefazolin with Tobramycin or Gentamicin as Intraoperative Antibiotic Prophylaxis for Single-Level Posterior Lumbar Fusion
Dhodapkar M, Jeong S, Halperin S, Rubio D, Li M, Grauer J. Cefazolin Alone Versus Cefazolin with Tobramycin or Gentamicin as Intraoperative Antibiotic Prophylaxis for Single-Level Posterior Lumbar Fusion. JAAOS Global Research And Reviews 2024, 8: e24.00082. PMCID: PMC11068128, DOI: 10.5435/jaaosglobal-d-24-00082.Peer-Reviewed Original ResearchSingle-level posterior lumbar fusionPosterior lumbar fusionSurgical site infectionElixhauser Comorbidity IndexLumbar fusionAntibiotic prophylaxisAdverse outcomesAntibiotic prophylaxis regimenAntibiotic prophylaxis regimensIntraoperative antibiotic prophylaxisRevision ratePerioperative antibiotic prophylaxisPostoperative adverse outcomesPosterior lumbar fusion patientsMultivariate logistic regressionProphylaxis regimensProphylaxis regimenPatient ageSite infectionUnivariate analysisCefazolinComorbidity indexMultivariate analysisAntibiotic subgroupsTraumatic diagnoses
2023
Incidental Durotomy After Posterior Lumbar Decompression Surgery Associated With Increased Risk for Venous Thromboembolism
Gouzoulis M, Joo P, Caruana D, Kammien A, Rubio D, Grauer J. Incidental Durotomy After Posterior Lumbar Decompression Surgery Associated With Increased Risk for Venous Thromboembolism. Journal Of The American Academy Of Orthopaedic Surgeons 2023, 31: e445-e450. PMID: 36727948, DOI: 10.5435/jaaos-d-22-00917.Peer-Reviewed Original ResearchConceptsLumbar decompression surgeryPosterior lumbar decompression surgeryRisk of VTEVenous thromboembolismIncidental durotomyDecompression surgeryMultivariate analysisOdds of VTETiming of VTEMore VTEDecompression patientsDurotomy groupPatient demographicsPulmonary embolismAdult patientsDegenerative etiologyBed restLumbar laminectomyPatient recoveryUnivariate analysisSpinal surgeryAdministrative codingDurotomySurgeryPatients