2022
PD10-02 AVELUMAB FIRST-LINE MAINTENANCE FOR ADVANCED UROTHELIAL CARCINOMA: LONG-TERM FOLLOW-UP RESULTS FROM THE JAVELIN BLADDER 100 TRIAL
Grivas P, Bellmunt J, Park H, Voog E, Caserta C, Valderrama B, Gurney H, Loriot Y, Sridhar S, Tsuchiya N, Sternberg C, Aragon-Ching J, Petrylak D, Blake-Haskins J, Laliberte R, Wang J, Costa N, Powles T. PD10-02 AVELUMAB FIRST-LINE MAINTENANCE FOR ADVANCED UROTHELIAL CARCINOMA: LONG-TERM FOLLOW-UP RESULTS FROM THE JAVELIN BLADDER 100 TRIAL. Journal Of Urology 2022, 207: e183. DOI: 10.1097/ju.0000000000002536.02.Peer-Reviewed Original Research
2021
MP41-13 AVELUMAB FIRST-LINE MAINTENANCE FOR ADVANCED UROTHELIAL CARCINOMA: ANALYSIS OF CLINICAL AND GENOMIC SUBGROUPS FROM THE JAVELIN BLADDER 100 TRIAL
Powles T, Petrylak D, Park H, Sridhar S, Caserta C, Thiery-Vuillemin A, Lee H, Bellmunt J, Yamamoto Y, Aragon-Ching J, Huang B, Ching K, Davis C, di Pietro A, Loriot Y, Grivas P. MP41-13 AVELUMAB FIRST-LINE MAINTENANCE FOR ADVANCED UROTHELIAL CARCINOMA: ANALYSIS OF CLINICAL AND GENOMIC SUBGROUPS FROM THE JAVELIN BLADDER 100 TRIAL. Journal Of Urology 2021, 206: e765-e766. DOI: 10.1097/ju.0000000000002062.13.Peer-Reviewed Original Research698P Analysis of hard-to-treat subgroups from EV-301: A phase III trial of enfortumab vedotin (EV) vs chemotherapy for previously treated advanced urothelial carcinoma
Rosenberg J, Powles T, Sonpavde G, Loriot Y, Duran I, Lee J, Matsubara N, Vulsteke C, Castellano D, Mamtani R, Sridhar S, Pappot H, Gurney H, Bedke J, van der Heijden M, Campbell M, Wu C, Matsangou M, Petrylak D. 698P Analysis of hard-to-treat subgroups from EV-301: A phase III trial of enfortumab vedotin (EV) vs chemotherapy for previously treated advanced urothelial carcinoma. Annals Of Oncology 2021, 32: s710-s711. DOI: 10.1016/j.annonc.2021.08.094.Peer-Reviewed Original Research
2020
A phase III, randomized, open-label study of first-line durvalumab (D) with or without tremelimumab (T) vs standard of care chemotherapy in patients with unresectable, locally advanced or metastatic urothelial carcinoma (DANUBE)
Powles T, van der Heijden M, Gauna D, Loriot Y, Galsky M, Petrylak D, Ogawa O, Park S, Necchi A, Lee J, De Giorgi U, Bögemann M, Bamias A, Fay A, Duran I, Angra N, Gupta A, He P, Levin W, Bellmunt J. A phase III, randomized, open-label study of first-line durvalumab (D) with or without tremelimumab (T) vs standard of care chemotherapy in patients with unresectable, locally advanced or metastatic urothelial carcinoma (DANUBE). Annals Of Oncology 2020, 31: s550-s551. DOI: 10.1016/j.annonc.2020.08.769.Peer-Reviewed Original ResearchAvelumab first-line (1L) maintenance + best supportive care (BSC) vs BSC alone for advanced urothelial carcinoma (UC): Association between clinical outcomes and exploratory biomarkers
Powles T, Loriot Y, Bellmunt J, Sternberg C, Sridhar S, Petrylak D, Tambaro R, Dourthe L, Alvarez-Fernandez C, Aarts M, Mu X, Ching K, Pu J, Roychoudhury S, Davis C, di Pietro A, Grivas P. Avelumab first-line (1L) maintenance + best supportive care (BSC) vs BSC alone for advanced urothelial carcinoma (UC): Association between clinical outcomes and exploratory biomarkers. Annals Of Oncology 2020, 31: s552-s553. DOI: 10.1016/j.annonc.2020.08.771.Peer-Reviewed Original Research
2019
O1 Activity of the FGFR1–3 inhibitor infigratinib in patients with upper tract urothelial carcinoma and urothelial carcinoma of the bladder: Latest efficacy findings and comprehensive genomic profiling/cell-free DNA data
De Giorgi U, Pal S, Rosenberg J, Hoffman-Censits J, Quinn D, Petrylak D, Galsky M, Vaishampayan U, Gupta S, Burris H, Soifer H, Li G, Dambkowski C, Moran S, Ye Y, Daneshmand S, Delord J, Bajorin D. O1 Activity of the FGFR1–3 inhibitor infigratinib in patients with upper tract urothelial carcinoma and urothelial carcinoma of the bladder: Latest efficacy findings and comprehensive genomic profiling/cell-free DNA data. European Urology Open Science 2019, 18: e3405-e3406. DOI: 10.1016/s1569-9056(19)34582-8.Peer-Reviewed Original ResearchDurability of complete response (CR) with atezolizumab (atezo) in locally advanced/metastatic urothelial carcinoma (mUC).
Loriot Y, Balar A, Dreicer R, Hoffman-Censits J, Perez-Gracia J, Petrylak D, Van Der Heijden M, Shen X, Zhu Q, Ding B, Kaiser C, Rosenberg J. Durability of complete response (CR) with atezolizumab (atezo) in locally advanced/metastatic urothelial carcinoma (mUC). Journal Of Clinical Oncology 2019, 37: 4527-4527. DOI: 10.1200/jco.2019.37.15_suppl.4527.Peer-Reviewed Original ResearchTreatment of locally advanced or metastatic urothelial carcinoma: Analysis of expert and community healthcare provider practice trends.
Rosenthal K, Galsky M, Milowsky M, Petrylak D, Rosenberg J, Obholz K, Plimack E. Treatment of locally advanced or metastatic urothelial carcinoma: Analysis of expert and community healthcare provider practice trends. Journal Of Clinical Oncology 2019, 37: 389-389. DOI: 10.1200/jco.2019.37.7_suppl.389.Peer-Reviewed Original ResearchImmune checkpoint inhibitorsCisplatin-based chemotherapyMetastatic urothelial carcinomaUrothelial carcinomaHealthcare providersExact testDifferent immune checkpoint inhibitorsPD-L1 testingFischer's exact testFDA label changePearson chi-squaredEligible ptsCheckpoint inhibitorsEligible casesTreatment indicationsTreatment decisionsClinical practicePractice trendsNew indicationsExpert recommendationsChi-squaredCarcinomaLabel changes
2018
865PD RANGE, a phase III, randomized, placebo-controlled, double-blind trial of ramucirumab (RAM) and docetaxel (DOC) in platinum-refractory urothelial carcinoma (UC): Overall survival results
Petrylak D, Sternberg C, Drakaki A, de Wit R, Nishiyama H, Necchi A, Castellano D, Bamias A, Chi K, van der Heijden M, Matsubara N, Hussain S, Flechon A, Alekseev B, Yu E, Walgren R, Russo F, Zimmermann A, Bell-Mcguinn K, Powles T. 865PD RANGE, a phase III, randomized, placebo-controlled, double-blind trial of ramucirumab (RAM) and docetaxel (DOC) in platinum-refractory urothelial carcinoma (UC): Overall survival results. Annals Of Oncology 2018, 29: viii304-viii305. DOI: 10.1093/annonc/mdy283.074.Peer-Reviewed Original Research930TiP Phase II/III study of rogaratinib versus chemotherapy in patients with locally advanced or metastatic urothelial carcinoma selected based on FGFR1/3 mRNA expression
Sternberg C, Bellmunt J, Nishiyama H, Petrylak D, Quinn D, Nakajima K, Lu C, Holynskyj A. 930TiP Phase II/III study of rogaratinib versus chemotherapy in patients with locally advanced or metastatic urothelial carcinoma selected based on FGFR1/3 mRNA expression. Annals Of Oncology 2018, 29: viii331. DOI: 10.1093/annonc/mdy283.139.Peer-Reviewed Original ResearchMP78-07 CLINICAL CHARACTERISTICS ASSOCIATED WITH EARLY PROGRESSION OR LONG-TERM RESPONSE FROM THE PHASE II IMVIGOR210 STUDY: ATEZOLIZUMAB IN LOCALLY ADVANCED OR METASTATIC UROTHELIAL CARCINOMA
Joseph R, Loriot Y, Perez-Gracia J, Dreicer R, Petrylak D, van der Heijden M, Hoffman-Censits J, Shen X, Fear S, Pavlova J, Rosenberg J. MP78-07 CLINICAL CHARACTERISTICS ASSOCIATED WITH EARLY PROGRESSION OR LONG-TERM RESPONSE FROM THE PHASE II IMVIGOR210 STUDY: ATEZOLIZUMAB IN LOCALLY ADVANCED OR METASTATIC UROTHELIAL CARCINOMA. Journal Of Urology 2018, 199: e1039. DOI: 10.1016/j.juro.2018.02.2555.Peer-Reviewed Original Research
2016
285TiP DANUBE: A Phase 3 randomised study of first-line durvalumab (MEDI4736) ± tremelimumab vs standard of care (SoC) chemotherapy (CT) in patients (pts) with Stage IV urothelial carcinoma (UC)
Park S, Castellano D, Petrylak D, Galsky M, van der Heijden M, Loriot Y, Ogawa O, Su W, Huang W, Levin W, Ferro S, Ben Y, Bellmunt J, Powles T. 285TiP DANUBE: A Phase 3 randomised study of first-line durvalumab (MEDI4736) ± tremelimumab vs standard of care (SoC) chemotherapy (CT) in patients (pts) with Stage IV urothelial carcinoma (UC). Annals Of Oncology 2016, 27 DOI: 10.1093/annonc/mdw583.011.Peer-Reviewed Original Research285TiP DANUBE: A Phase 3 randomised study of first-line durvalumab (MEDI4736) 6 tremelimumab vs standard of care (SoC) chemotherapy (CT) in patients (pts) with Stage IV urothelial carcinoma (UC)
Park S, Castellano D, Petrylak D, Galsky M, van der Heijden M, Loriot Y, Ogawa O, Su W, Huang W, Levin W, Ferro S, Ben Y, Bellmunt J, Powles T. 285TiP DANUBE: A Phase 3 randomised study of first-line durvalumab (MEDI4736) 6 tremelimumab vs standard of care (SoC) chemotherapy (CT) in patients (pts) with Stage IV urothelial carcinoma (UC). Annals Of Oncology 2016, 27: ix88-ix89. DOI: 10.1016/s0923-7534(21)00442-7.Peer-Reviewed Original ResearchUpdated efficacy and > 1-y follow up from IMvigor210: Atezolizumab (atezo) in platinum (plat) treated locally advanced/metastatic urothelial carcinoma (mUC).
Dreicer R, Hoffman-Censits J, Flaig T, Grande E, Balmanoukian A, von Amsberg G, Theodore C, Chowdhury S, Bracarda S, Clement J, Yu E, Rezazadeh Kalebasty A, Niegisch G, Culine S, Gordon M, Cui N, Mariathasan S, Legrand F, Abidoye O, Petrylak D. Updated efficacy and > 1-y follow up from IMvigor210: Atezolizumab (atezo) in platinum (plat) treated locally advanced/metastatic urothelial carcinoma (mUC). Journal Of Clinical Oncology 2016, 34: 4515-4515. DOI: 10.1200/jco.2016.34.15_suppl.4515.Peer-Reviewed Original ResearchThe 2nd meeting of the Campania Society of Oncology Immunotherapy (SCITO): focus on hepatocellular carcinoma, kidney and bladder cancer
Daniele B, Sangro B, Petrylak D, Calabrò F, Cartenì G, Montesarchio V, De Placido S, Ascierto P. The 2nd meeting of the Campania Society of Oncology Immunotherapy (SCITO): focus on hepatocellular carcinoma, kidney and bladder cancer. Journal For ImmunoTherapy Of Cancer 2016, 4: 1. PMCID: PMC4717673, DOI: 10.1186/s40425-015-0105-x.Peer-Reviewed Original Research
2015
21LBA Atezolizumab in patients (pts) with locally-advanced or metastatic urothelial carcinoma (mUC): Results from a pivotal multicenter phase II study (IMvigor 210)
Rosenberg J, Petrylak D, Abidoye O, Van der Heijden M, Hofman-Censits J, Necchi A, O'Donnell P, Balmanoukian A, Loriot Y, Retz M, Perez-Gracia J, Dawson N, Balar A, Galsky M, Fleming M, Powles T, Cui N, Mariathasan S, Fine G, Dreicer R. 21LBA Atezolizumab in patients (pts) with locally-advanced or metastatic urothelial carcinoma (mUC): Results from a pivotal multicenter phase II study (IMvigor 210). European Journal Of Cancer 2015, 51: s720. DOI: 10.1016/s0959-8049(16)31942-6.Peer-Reviewed Original Research
2012
1769 UPDATED RESULTS OF THE COMBINED PHASE I/II TRIAL OF INTRAVESICAL NANOPARTICLE ALBUMIN-BOUND PACLITAXEL IN THE TREATMENT OF BCG REFRACTORY NON-MUSCLE INVASIVE TRANSITIONAL CELL CARCINOMA
McKiernan J, Holder D, Kates M, Badalato G, Barlow L, RoyChoudhury A, Petrylak D, Benson M. 1769 UPDATED RESULTS OF THE COMBINED PHASE I/II TRIAL OF INTRAVESICAL NANOPARTICLE ALBUMIN-BOUND PACLITAXEL IN THE TREATMENT OF BCG REFRACTORY NON-MUSCLE INVASIVE TRANSITIONAL CELL CARCINOMA. Journal Of Urology 2012, 187: e714. DOI: 10.1016/j.juro.2012.02.1786.Peer-Reviewed Original Research
2005
Trastuzumab (T), paclitaxel (P), carboplatin (C), and gemcitabine (G) in advanced HER2-positive urothelial carcinoma: Results of a multi-center phase II NCI trial
Hussain M, Petrylak D, Dunn R, Vaishampayan U, Lara P, Chatta G, Nanus D, Glode L, Trump D, Chen H, Smith D. Trastuzumab (T), paclitaxel (P), carboplatin (C), and gemcitabine (G) in advanced HER2-positive urothelial carcinoma: Results of a multi-center phase II NCI trial. Journal Of Clinical Oncology 2005, 23: 4507-4507. DOI: 10.1200/jco.2005.23.16_suppl.4507.Peer-Reviewed Original Research
2004
Paclitaxel, carboplatin and gemcitabine (PCG) as neoadjuvant therapy in patients with locally advanced transitional cell carcinoma (TCC) of the bladder
Smith D, Bhandari M, Hussain M, Montie J, Wood D, Lee C, Petrylak D, Vaishampayan U. Paclitaxel, carboplatin and gemcitabine (PCG) as neoadjuvant therapy in patients with locally advanced transitional cell carcinoma (TCC) of the bladder. Journal Of Clinical Oncology 2004, 22: 4541-4541. DOI: 10.1200/jco.2004.22.14_suppl.4541.Peer-Reviewed Original ResearchPhase I/II study of docetaxel (D), gemcitabine (G), Carboplatin (C) in poor prognosis and previously treated patients (pts) with urothelial carcinoma (UTC)
Chen A, Hovey E, Shelton G, Fitzsimmons J, Randall A, Taub R, Petrylak D. Phase I/II study of docetaxel (D), gemcitabine (G), Carboplatin (C) in poor prognosis and previously treated patients (pts) with urothelial carcinoma (UTC). Journal Of Clinical Oncology 2004, 22: 4580-4580. DOI: 10.1200/jco.2004.22.14_suppl.4580.Peer-Reviewed Original Research