Featured Publications
Towards understanding and predicting suicidality in women: biomarkers and clinical risk assessment
Levey DF, Niculescu EM, Le-Niculescu H, Dainton HL, Phalen PL, Ladd TB, Weber H, Belanger E, Graham DL, Khan FN, Vanipenta NP, Stage EC, Ballew A, Yard M, Gelbart T, Shekhar A, Schork NJ, Kurian SM, Sandusky GE, Salomon DR, Niculescu AB. Towards understanding and predicting suicidality in women: biomarkers and clinical risk assessment. Molecular Psychiatry 2016, 21: 768-785. PMID: 27046645, DOI: 10.1038/mp.2016.31.Peer-Reviewed Original ResearchConceptsFuture hospitalizationConvergent functional genomics approachSuicide completersPrimary end pointSingle blood biomarkerTop biomarkersReceiver-operating characteristic areaRisk prediction scoreClinical risk assessmentDisorder participantsIndependent test cohortForm of APPProphylactic benefitNeurotrophic effectsBlood biomarkersSleep abnormalitiesPsychiatric hospitalizationHospitalizationMood disordersTest cohortCandidate biomarkersSuicide completionSuicidal ideationDrug lithiumChronic stress
2015
Understanding and predicting suicidality using a combined genomic and clinical risk assessment approach
Niculescu AB, Levey DF, Phalen PL, Le-Niculescu H, Dainton HD, Jain N, Belanger E, James A, George S, Weber H, Graham DL, Schweitzer R, Ladd TB, Learman R, Niculescu EM, Vanipenta NP, Khan FN, Mullen J, Shankar G, Cook S, Humbert C, Ballew A, Yard M, Gelbart T, Shekhar A, Schork NJ, Kurian SM, Sandusky GE, Salomon DR. Understanding and predicting suicidality using a combined genomic and clinical risk assessment approach. Molecular Psychiatry 2015, 20: 1266-1285. PMID: 26283638, PMCID: PMC4759104, DOI: 10.1038/mp.2015.112.Peer-Reviewed Original ResearchConceptsFuture hospitalizationPsychiatric diagnosisSuicidal ideationCandidate biomarkersBipolar disorderPsychiatric participantsBlood gene expression biomarkersSuicidal behaviorConvergent functional genomics approachSuicide completersPreventive lifestyle modificationsTop candidate biomarkersTop biomarkersAcute panic attacksPotential therapeutic targetBipolar disorder participantsMajor psychiatric disordersIndependent test cohortSuicide risk factorsThoughts of suicideLifestyle modificationAcute suicidalityRisk factorsInflammatory responsePsychological stress responses