2017
Mapping Extracellular pH of Gliomas in Presence of Superparamagnetic Nanoparticles: Towards Imaging the Distribution of Drug‐Containing Nanoparticles and Their Curative Effect on the Tumor Microenvironment
Maritim S, Coman D, Huang Y, Rao JU, Walsh JJ, Hyder F. Mapping Extracellular pH of Gliomas in Presence of Superparamagnetic Nanoparticles: Towards Imaging the Distribution of Drug‐Containing Nanoparticles and Their Curative Effect on the Tumor Microenvironment. Contrast Media & Molecular Imaging 2017, 2017: 3849373. PMID: 29362558, PMCID: PMC5736903, DOI: 10.1155/2017/3849373.Peer-Reviewed Original ResearchConceptsBrain microvasculatureCurative effectTherapeutic effectIntravenous injectionTherapeutic impactTumor typesD-NPsTumor microenvironmentSuperparamagnetic iron oxideTumor hallmarksGliomasDrug distributionInfusionMRI contrastHealing efficacyMRI readoutsMicrovasculatureDrugsExtracellular pHDrug-containing nanoparticlesTumor-targeted nanoparticlesSPIO NPsTumor boundaries
2016
Towards longitudinal mapping of extracellular pH in gliomas
Huang Y, Coman D, Herman P, Rao JU, Maritim S, Hyder F. Towards longitudinal mapping of extracellular pH in gliomas. NMR In Biomedicine 2016, 29: 1364-1372. PMID: 27472471, PMCID: PMC5035200, DOI: 10.1002/nbm.3578.Peer-Reviewed Original ResearchConceptsSurgical interventionPlasma concentrationsU87 brain tumorsPreclinical modelsRenal clearanceSame subjectsTumor assessmentBrain tumorsProbe doseTherapeutic monitoringTranslational valueTumor characterizationLongitudinal scansChemical shift imaging techniqueThulium ionsMolecular imagingParamagnetic probesInterventionScansImaging techniquesSubjectsNon-exchangeable protonsImaging the intratumoral–peritumoral extracellular pH gradient of gliomas
Coman D, Huang Y, Rao JU, De Feyter HM, Rothman DL, Juchem C, Hyder F. Imaging the intratumoral–peritumoral extracellular pH gradient of gliomas. NMR In Biomedicine 2016, 29: 309-319. PMID: 26752688, PMCID: PMC4769673, DOI: 10.1002/nbm.3466.Peer-Reviewed Original ResearchConceptsRG2 tumorsTumor typesKi-67-positive cellsCancer therapeutic responseAcidic pHeTherapeutic responseRat brainPositive cellsSolid tumorsTumor cell invasionTumor borderTumorsPeritumoral regionNormal tissuesCell invasionTumor pHeP-MRSCancer imagingNeutral intracellularImagingPreclinical applicationsInfusionTherapy
2014
Caloric Restriction Impedes Age-Related Decline of Mitochondrial Function and Neuronal Activity
Lin AL, Coman D, Jiang L, Rothman DL, Hyder F. Caloric Restriction Impedes Age-Related Decline of Mitochondrial Function and Neuronal Activity. Cerebrovascular And Brain Metabolism Reviews 2014, 34: 1440-1443. PMID: 24984898, PMCID: PMC4158670, DOI: 10.1038/jcbfm.2014.114.Peer-Reviewed Original ResearchMeSH KeywordsAgingAnimalsCaloric RestrictionGlutamic AcidGlutamineMaleMitochondriaRatsRats, Inbred F344Synaptic TransmissionConceptsOld CR ratsNeuronal activityYoung controlsCR ratsCaloric restriction (CR) prolongs lifespanHealthy agingNeuronal glucose oxidationBrain mitochondrial functionNeuronal energy productionMitochondrial functionAge-related declineNeurotransmitter cyclingOlder controlsNeurotransmission ratesBrain physiologyRatsGlucose oxidationProlong lifespanVivo nuclear magnetic resonance (NMR) spectroscopyMagnetic resonance spectroscopyDetrimental effectsAgingControl