2005
A Nuclear Magnetic Resonance Investigation of the Energetics of Basepair Opening Pathways in DNA
Coman D, Russu IM. A Nuclear Magnetic Resonance Investigation of the Energetics of Basepair Opening Pathways in DNA. Biophysical Journal 2005, 89: 3285-3292. PMID: 16126830, PMCID: PMC1366824, DOI: 10.1529/biophysj.105.065763.Peer-Reviewed Original ResearchConceptsOpening reactionFree energyNuclear magnetic resonance investigationFree energy relationshipsMagnetic resonance investigationNMR spectroscopySolvent protonsProton exchangeEnergy relationshipsTransition stateExchange catalystResonance investigationOpening pathwaysRate of exchangeEquilibrium constantsEnthalpy changeDNA duplexImino protonsReactionNeighboring basesProtonsDifferent temperaturesEnergeticsOpen stateCatalyst
2004
Site‐resolved stabilization of a DNA triple helix by magnesium ions
Coman D, Russu IM. Site‐resolved stabilization of a DNA triple helix by magnesium ions. Nucleic Acids Research 2004, 32: 878-883. PMID: 14769945, PMCID: PMC373380, DOI: 10.1093/nar/gkh228.Peer-Reviewed Original ResearchConceptsDNA triple helicesBase pairsTriple helixIndividual base pairsMolecular roleClosed conformationDNA triple-helical structuresTriple helical structureSame helixCorresponding base pairsPresence of Mg2HelixImino protonsParallel triple helicesObserved baseDNA oligonucleotideNew insightsWatson-CrickRate of exchangeMg2DNANMR spectroscopyEffect of Mg2Magnesium ionsCytosine
2003
Probing Hydrogen Bonding in a DNA Triple Helix Using Protium−Deuterium Fractionation Factors
Coman D, Russu IM. Probing Hydrogen Bonding in a DNA Triple Helix Using Protium−Deuterium Fractionation Factors. Journal Of The American Chemical Society 2003, 125: 6626-6627. PMID: 12769560, DOI: 10.1021/ja034223b.Peer-Reviewed Original Research