2008
Modulation of the spatial attention network by incentives in healthy aging and mild cognitive impairment
Bagurdes LA, Mesulam MM, Gitelman DR, Weintraub S, Small DM. Modulation of the spatial attention network by incentives in healthy aging and mild cognitive impairment. Neuropsychologia 2008, 46: 2943-2948. PMID: 18602410, DOI: 10.1016/j.neuropsychologia.2008.06.005.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAgingAnalysis of VarianceAttentionCase-Control StudiesCerebral CortexCognition DisordersDementiaDiscrimination, PsychologicalHumansLimbic SystemMagnetic Resonance ImagingMatched-Pair AnalysisMiddle AgedMotivationReaction TimeReference ValuesRewardSeverity of Illness IndexSpace PerceptionConceptsSpatial attentionSpatial attention networkAttentional shiftsMild cognitive impairmentAttention networkHealthy agingOrbitofrontal cortexCovert attention taskSelective spatial attentionCognitive impairmentUnderlying neural circuitryAD-related declineAttention taskSelective attentionEmotional contentOFC activationPCC activationSpatial cuesSecondary reinforcerInfluence of incentivesPosterior cingulateNeural circuitryNovel eventsCurrent experimentsBehavioral effectsSleep deprivation alters functioning within the neural network underlying the covert orienting of attention
Mander BA, Reid KJ, Davuluri VK, Small DM, Parrish TB, Mesulam MM, Zee PC, Gitelman DR. Sleep deprivation alters functioning within the neural network underlying the covert orienting of attention. Brain Research 2008, 1217: 148-156. PMID: 18511023, PMCID: PMC2528837, DOI: 10.1016/j.brainres.2008.04.030.Peer-Reviewed Original ResearchConceptsReaction time benefitsFunctional magnetic resonance imagingSpatial attentionPosterior cingulate cortex activationTime benefitsLeft intraparietal sulcusGoal-directed interactionsSleep-deprived individualsSleep deprivation altersInvalid cuesUninformative cuesNeural resourcesValid cuesCovert orientingSelective attentionIrrelevant locationsPCC activationIntraparietal sulcusUpcoming eventsCortex activationBrain activityNormal restPCC activityCuesYoung adultsThe Spatial Attention Network Interacts with Limbic and Monoaminergic Systems to Modulate Motivation-Induced Attention Shifts
Mohanty A, Gitelman DR, Small DM, Mesulam MM. The Spatial Attention Network Interacts with Limbic and Monoaminergic Systems to Modulate Motivation-Induced Attention Shifts. Cerebral Cortex 2008, 18: 2604-2613. PMID: 18308706, PMCID: PMC2567423, DOI: 10.1093/cercor/bhn021.Peer-Reviewed Original ResearchConceptsPosterior parietal cortexSpatial attentionPosterior cingulateAttentional targetsSpatial attention paradigmFood-related cuesStrong functional couplingAttentional biasingAttentional resourcesAttentional shiftsMotivational relevanceAttention paradigmCentral cuesAttention shiftsMotivational salienceMotivational valueMotivational informationMotivational stateMotivational needsIntraparietal sulcusOrbitofrontal cortexParietal cortexFood targetsSelective allocationMultiple domains
2005
Monetary Incentives Enhance Processing in Brain Regions Mediating Top-down Control of Attention
Small DM, Gitelman D, Simmons K, Bloise SM, Parrish T, Mesulam M. Monetary Incentives Enhance Processing in Brain Regions Mediating Top-down Control of Attention. Cerebral Cortex 2005, 15: 1855-1865. PMID: 15746002, DOI: 10.1093/cercor/bhi063.Peer-Reviewed Original ResearchConceptsSpatial expectancyVisual spatial attentionNon-directional cuesCurrent behavioral goalsControl of attentionTarget detection taskFaster reaction timesInferior parietal lobulePosterior cingulate cortexDifferent incentive conditionsValid cuesCentral cuesSpatial attentionMotivational mechanismsNeural processingMotivational incentivesUnimodal cortexBehavioral goalsLimbic mechanismsParietal lobuleAttention networkDetection taskCingulate cortexRelationship of activationIncentive conditionsChapter 6 A Heteromodal Large-Scale Network for Spatial Attention
Mesulam M, Small D, Vandenberghe R, Gitelman D, Nobre A. Chapter 6 A Heteromodal Large-Scale Network for Spatial Attention. 2005, 29-34. DOI: 10.1016/b978-012375731-9/50010-0.Peer-Reviewed Original ResearchSpatial attentionRight hemisphere lesionsAttentional focusMotivational salienceMental representationsRight hemispaceNetwork subservingContralesional neglectExtrapersonal spaceLeft hemisphereRight hemisphereHemispatial neglectParietal syndromeHemisphere lesionsCingulate gyrusFrontal lobeHemispaceNeglectAttentionLarge-scale networksHemisphereSalienceSubservingGyrusChapter 6
2003
The posterior cingulate and medial prefrontal cortex mediate the anticipatory allocation of spatial attention
Small DM, Gitelman DR, Gregory MD, Nobre AC, Parrish TB, Mesulam M. The posterior cingulate and medial prefrontal cortex mediate the anticipatory allocation of spatial attention. NeuroImage 2003, 18: 633-641. PMID: 12667840, DOI: 10.1016/s1053-8119(02)00012-5.Peer-Reviewed Original ResearchConceptsMedial prefrontal cortexCue benefitPrefrontal cortexPosterior cingulateAttention-related areasNeutral cuesCentral cuesSpatial attentionSpatial expectancyFMRI scanningIrrelevant locationsMotivational valenceGreater activationParietal cortexBrain regionsCuesPeripheral targetsReaction timeCingulateCortexDistractibilityExpectancySignificant eventsAttentionValence