2016
Fuel not fun: Reinterpreting attenuated brain responses to reward in obesity
Kroemer NB, Small DM. Fuel not fun: Reinterpreting attenuated brain responses to reward in obesity. Physiology & Behavior 2016, 162: 37-45. PMID: 27085908, PMCID: PMC4971522, DOI: 10.1016/j.physbeh.2016.04.020.Peer-Reviewed Original ResearchConceptsFood-related stimuliBrain responsesReward-related learningReward sensitivityReward deficiencyReduced reward sensitivityPrimary food rewardReward receiptMilkshake receiptStriatal responsesReward deficitsFood rewardSubjective valueReinforcement learning frameworkRewardDopamine signalingFood anticipationDorsal striatumAnhedoniaAnticipatoryDopaminergic regionsStimuliConsummatory responsesAlternative viewLearning
2010
Genetically Determined Differences in Brain Response to a Primary Food Reward
Felsted JA, Ren X, Chouinard-Decorte F, Small DM. Genetically Determined Differences in Brain Response to a Primary Food Reward. Journal Of Neuroscience 2010, 30: 2428-2432. PMID: 20164326, PMCID: PMC2831082, DOI: 10.1523/jneurosci.5483-09.2010.Peer-Reviewed Original ResearchConceptsBrain responsesPrimary food rewardFunctional magnetic resonanceTaqIA A1 alleleOrbital frontal cortexReward driveIndividual differencesNeural responsesFuture weight gainFood rewardPalatable foodNeuroimaging techniquesPerceptual responsesBiological underpinningsIndividual factorsFrontal cortexImpulsivityDiminished dopamineSimilar ratingsFood reinforcementRewardSpecific associationNeurophysiologyMilkshakeBody mass index