2018
Food Intake Recruits Orosensory and Post-ingestive Dopaminergic Circuits to Affect Eating Desire in Humans
Thanarajah SE, Backes H, DiFeliceantonio AG, Albus K, Cremer AL, Hanssen R, Lippert RN, Cornely OA, Small DM, Brüning JC, Tittgemeyer M. Food Intake Recruits Orosensory and Post-ingestive Dopaminergic Circuits to Affect Eating Desire in Humans. Cell Metabolism 2018, 29: 695-706.e4. PMID: 30595479, DOI: 10.1016/j.cmet.2018.12.006.Peer-Reviewed Original ResearchConceptsDopaminergic circuitsHigher cognitive centersSegregated brain regionsPeripheral physiological signalsPalatable food intakeReward valueDopamine releaseCognitive centersSubjective desireBrain regionsBrain areasUnderlying reinforcementFood intakeDorsal striatumRole of brainPhysiological signalsFood selection behaviorIntegrative pathwaysFMRIDesirePET methodBrainHumansIntakeSelection behaviorSupra-Additive Effects of Combining Fat and Carbohydrate on Food Reward
DiFeliceantonio AG, Coppin G, Rigoux L, Thanarajah S, Dagher A, Tittgemeyer M, Small DM. Supra-Additive Effects of Combining Fat and Carbohydrate on Food Reward. Cell Metabolism 2018, 28: 33-44.e3. PMID: 29909968, DOI: 10.1016/j.cmet.2018.05.018.Peer-Reviewed Original Research
2016
Fuel not fun: Reinterpreting attenuated brain responses to reward in obesity
Kroemer NB, Small DM. Fuel not fun: Reinterpreting attenuated brain responses to reward in obesity. Physiology & Behavior 2016, 162: 37-45. PMID: 27085908, PMCID: PMC4971522, DOI: 10.1016/j.physbeh.2016.04.020.Peer-Reviewed Original ResearchConceptsFood-related stimuliBrain responsesReward-related learningReward sensitivityReward deficiencyReduced reward sensitivityPrimary food rewardReward receiptMilkshake receiptStriatal responsesReward deficitsFood rewardSubjective valueReinforcement learning frameworkRewardDopamine signalingFood anticipationDorsal striatumAnhedoniaAnticipatoryDopaminergic regionsStimuliConsummatory responsesAlternative viewLearning
2015
Opposing relationships of BMI with BOLD and dopamine D2/3 receptor binding potential in the dorsal striatum
Cosgrove KP, Veldhuizen MG, Sandiego CM, Morris ED, Small DM. Opposing relationships of BMI with BOLD and dopamine D2/3 receptor binding potential in the dorsal striatum. Synapse 2015, 69: 195-202. PMID: 25664726, PMCID: PMC4411955, DOI: 10.1002/syn.21809.Peer-Reviewed Original ResearchConceptsBody mass indexPalatable food consumptionDorsal striatumMass indexBOLD responseReceptor availabilityRelationship of BMIFood consumptionPET studiesMagnetic resonance imaging studyPositron emission tomography studyBlood oxygen level-dependent (BOLD) responseDopamine D2/3 receptorsHigh-fat dietDopamine receptor levelsEmission tomography studiesFMRI studyResonance imaging studyFunctional magnetic resonance imaging studyLevel-dependent responsesReliable inverse relationshipHealthy weightD2/3 receptorsStriatal circuitryFat diet
2013
Decreased caudate response to milkshake is associated with higher body mass index and greater impulsivity
Babbs RK, Sun X, Felsted J, Chouinard-Decorte F, Veldhuizen MG, Small DM. Decreased caudate response to milkshake is associated with higher body mass index and greater impulsivity. Physiology & Behavior 2013, 121: 103-111. PMID: 23562867, PMCID: PMC3731396, DOI: 10.1016/j.physbeh.2013.03.025.Peer-Reviewed Original ResearchConceptsBody mass indexCaudate responseMass indexCaudate nucleusBrain responsesHigher body mass indexWeight gainHealthy weight subjectsTasteless control solutionEnergy-dense foodsSelf-reported impulsivityWeight subjectsNegative associationVentral putamenDorsal striatumFood rewardDense foodsSignificant associationInverse correlationMilkshakeOverweightGreater impulsivityMeasures of impulsivityGreater responseAssociation
2008
Relation Between Obesity and Blunted Striatal Response to Food Is Moderated by TaqIA A1 Allele
Stice E, Spoor S, Bohon C, Small DM. Relation Between Obesity and Blunted Striatal Response to Food Is Moderated by TaqIA A1 Allele. Science 2008, 322: 449-452. PMID: 18927395, PMCID: PMC2681095, DOI: 10.1126/science.1161550.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAllelesBasal GangliaBody Mass IndexCaudate NucleusCorpus StriatumCuesDeoxyribonucleases, Type II Site-SpecificDopamineEatingFemaleFoodHumansHyperphagiaMagnetic Resonance ImagingObesityPolymorphism, Restriction Fragment LengthPutamenReceptors, Dopamine D2Regression AnalysisRewardSignal TransductionWeight GainConceptsDorsal striatumTaqIA restriction fragment length polymorphismConsummatory food rewardMagnetic resonance imaging studyStriatal dopamine receptorsDevelopment of obesityA1 alleleResonance imaging studyFunctional magnetic resonance imaging studyDopamine D2 receptor geneTaqIA A1 alleleObese individualsStriatal dopamineD2 receptor geneProspective dataLean individualsDopamine receptorsFood intakeStriatumImaging studiesStriatal responsesStriatal activationGenetic polymorphismsReceptor geneObesity