Rhesus Macaque Model of Pulmonary Aging and Non-tuberculous Mycobacterium Infection Reveals Age Related Mechanisms of Disease Severity
Rhoades N, Davies M, Kohama S, Bermudez L, Winthrop K, Mattison J, Fuss C, Spindel E, Messaoudi I. Rhesus Macaque Model of Pulmonary Aging and Non-tuberculous Mycobacterium Infection Reveals Age Related Mechanisms of Disease Severity. 2022, a2155-a2155. DOI: 10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a2155.Peer-Reviewed Original ResearchFunctional, transcriptional, and microbial shifts associated with healthy pulmonary aging in rhesus macaques
Rhoades N, Davies M, Lewis S, Cinco I, Kohama S, Bermudez L, Winthrop K, Fuss C, Mattison J, Spindel E, Messaoudi I. Functional, transcriptional, and microbial shifts associated with healthy pulmonary aging in rhesus macaques. Cell Reports 2022, 39: 110725. PMID: 35443183, PMCID: PMC9096119, DOI: 10.1016/j.celrep.2022.110725.Peer-Reviewed Original ResearchConceptsT cellsCD8<sup>+</sup> T cellsCD8<sup>+</sup> TRhesus macaque modelPulmonary function testsSevere respiratory infectionsSeverity of respiratory diseasePulmonary ageCross-sectional studyMacaque modelInfiltrating macrophagesImmunological landscapeRespiratory infectionsImpact of ageComprehensive cross-sectional studyIncreased riskAge-related changesFunction testsAged animalsIncreased prevalenceHealthy humansRespiratory tractRhesus macaquesConsequence of agingLung