An oral androgen receptor PROTAC degrader for prostate cancer.
Neklesa T, Snyder L, Willard R, Vitale N, Raina K, Pizzano J, Gordon D, Bookbinder M, Macaluso J, Dong H, Liu Z, Ferraro C, Wang G, Wang J, Crews C, Houston J, Crew A, Taylor I. An oral androgen receptor PROTAC degrader for prostate cancer. Journal Of Clinical Oncology 2018, 36: 381-381. DOI: 10.1200/jco.2018.36.6_suppl.381.Peer-Reviewed Original ResearchAndrogen receptorProstate cancerAR proteinAR target gene PSADegradation of AREnzalutamide-Resistant Prostate CancerCastration-resistant prostate cancerAR degradationMajority of patientsMouse xenograft studiesPreclinical efficacy studiesMutant AR proteinNon-rodent speciesAndrogen environmentMetastatic diseaseMost patientsAR signalingPreclinical dataAR pathwayMechanisms of resistanceDrug exposureXenograft studiesVCaP cellsEfficacy studiesExploratory toxicology studies