2024
Development and initial testing of mindful journey: a digital mindfulness-based intervention for promoting recovery from Substance use disorder
Roos C, Kiluk B, Carroll K, Bricker J, Mun C, Sala M, Kirouac M, Stein E, John M, Palmer R, DeBenedictis A, Frisbie J, Haeny A, Barry D, Fucito L, Bowen S, Witkiewitz K, Kober H. Development and initial testing of mindful journey: a digital mindfulness-based intervention for promoting recovery from Substance use disorder. Annals Of Medicine 2024, 56: 2315228. PMID: 38382111, PMCID: PMC10883107, DOI: 10.1080/07853890.2024.2315228.Peer-Reviewed Original ResearchConceptsSubstance use disordersMindfulness-based interventionsPhone coachingQualitative feedbackPromote recoveryEvidence of feasibilityUse disorderPhase 2Promote long-term recoveryApp featuresUnmet needsAdjunctive interventionTen adultsSmartphone appLong-term recoveryInterventionTherapy videosMindfulness practiceParticipantsOutpatient treatmentMind toolPhase 1CoachingAcceptance dimensionQuantitative ratings
2023
A Pilot Open Trial of a Digital Mindfulness-Based Intervention for Anorexia Nervosa
Sala M, Levinson C, Kober H, Roos C. A Pilot Open Trial of a Digital Mindfulness-Based Intervention for Anorexia Nervosa. Behavior Therapy 2023, 54: 637-651. PMID: 37330254, DOI: 10.1016/j.beth.2023.01.003.Peer-Reviewed Original ResearchConceptsEmotion regulationBody dissatisfactionState mindfulnessTrait mindfulnessSkill useDisorder symptomsAnorexia nervosaDigital mindfulness-based interventionMindfulness-based interventionsHigher state mindfulnessPilot open trialEcological momentary assessmentOpen trialPerson levelDaily lifeMeasures of acceptabilityED symptomsMindfulnessMomentary assessmentDigital mindfulnessDaily meditationMotivational supportAcceptability ratingsPost changesDissatisfactionPredictors of relapse in eating disorders: A meta-analysis
Sala M, Keshishian A, Song S, Moskowitz R, Bulik C, Roos C, Levinson C. Predictors of relapse in eating disorders: A meta-analysis. Journal Of Psychiatric Research 2023, 158: 281-299. PMID: 36623362, DOI: 10.1016/j.jpsychires.2023.01.002.Peer-Reviewed Original ResearchConceptsPredictors of relapseED relapseStudy-level effect sizesIndividual differencesPotential moderatorsED psychopathologyModerator effectsVariety of variablesHigh motivationED subtypesMultilevel mixed-effects modelsPredictor assessmentED onsetEffect sizeFuture researchMultilevel random effects modelsStrongest predictorModeratorPsychiatric comorbidityMixed effects modelsRandom-effects modelPredictorsDisordersHigher oddsBody fat
2021
Examining a brief measure and observed cutoff scores to identify reward and relief drinking profiles: Psychometric properties and pharmacotherapy response
Votaw VR, Mann K, Kranzler HR, Roos CR, Nakovics H, Witkiewitz K. Examining a brief measure and observed cutoff scores to identify reward and relief drinking profiles: Psychometric properties and pharmacotherapy response. Drug And Alcohol Dependence 2021, 232: 109257. PMID: 35042096, PMCID: PMC8885897, DOI: 10.1016/j.drugalcdep.2021.109257.Peer-Reviewed Original ResearchConceptsBrief measureCutoff scorePharmacotherapy responseAlcohol dependence severityItem response theoryGood construct validityNegative statesLatent profilesDrinking situationsDisorder outcomesDependence severityDifferential itemPsychometric propertiesDrinking subgroupDrinking measuresConstruct validityPositive experiencesHeavy drinkingRewardResponse theoryAUD medicationsDrinking profilesNaltrexone treatment responseDrinkingMeasuresDetecting change in psychiatric functioning in clinical trials for cocaine use disorder: sensitivity of the Addiction Severity Index and Brief Symptom Inventory
Kiluk BD, Roos CR, Aslan M, Gueorguieva R, Nich C, Babuscio TA, Carroll KM. Detecting change in psychiatric functioning in clinical trials for cocaine use disorder: sensitivity of the Addiction Severity Index and Brief Symptom Inventory. Drug And Alcohol Dependence 2021, 228: 109070. PMID: 34600247, PMCID: PMC8595796, DOI: 10.1016/j.drugalcdep.2021.109070.Peer-Reviewed Original ResearchConceptsAddiction Severity IndexGlobal Severity IndexPsychiatric composite scoreClinical trialsCocaine useCocaine use disorderPsychiatric functioningBrief Symptom InventorySeverity IndexUse disordersASI psychiatric composite scoreSymptom InventoryEffect sizeStart of treatmentComposite scoreClinical trial participantsWeek 12Functional outcomeTreatment periodTrial participantsPsychiatric problemsDrug usePotential functional benefitsMedium effect sizeSubstance usersAwareness, Affect, and Craving During Smoking Cessation: An Experience Sampling Study
Sala M, Roos CR, Brewer JA, Garrison KA. Awareness, Affect, and Craving During Smoking Cessation: An Experience Sampling Study. Health Psychology 2021, 40: 578-586. PMID: 34570534, PMCID: PMC8629854, DOI: 10.1037/hea0001105.Peer-Reviewed Original ResearchConceptsNegative affectHigher positive affectExperience samplingMindfulness trainingPositive affectExperience Sampling StudyLower negative affectBetween-person levelKey psychological variablesMultilevel linear modelingLower smokingPsychological variablesSmoking cessationAffective statesPerson levelPerson's awarenessLower cravingAffectCessation researchLinear modelingSampling studyMindfulnessBehavior changeSmartphone appTrainingWithin-AUD outpatient treatment heavy drinking transitions and associations with long-term outcomes
Maisto SA, Hallgren KA, Swan JE, Roos C, Witkiewitz K. Within-AUD outpatient treatment heavy drinking transitions and associations with long-term outcomes. Drug And Alcohol Dependence 2021, 228: 108968. PMID: 34560333, PMCID: PMC11170462, DOI: 10.1016/j.drugalcdep.2021.108968.Peer-Reviewed Original ResearchConceptsLong-term outcomesMindfulness and Eating Disorders: A Network Analysis
Sala M, Vanzhula I, Roos CR, Levinson CA. Mindfulness and Eating Disorders: A Network Analysis. Behavior Therapy 2021, 53: 224-239. PMID: 35227400, DOI: 10.1016/j.beth.2021.07.002.Peer-Reviewed Original ResearchMindfulness‐based interventions for eating disorders: The potential to mobilize multiple associative‐learning change mechanisms
Roos CR, Sala M, Kober H, Vanzhula IA, Levinson CA. Mindfulness‐based interventions for eating disorders: The potential to mobilize multiple associative‐learning change mechanisms. International Journal Of Eating Disorders 2021, 54: 1601-1607. PMID: 34061387, DOI: 10.1002/eat.23564.Peer-Reviewed Original ResearchConceptsMindfulness-based interventionsMindful acceptanceMindful awarenessOperant learningPatient-treatment matching hypothesesChange mechanismsPavlovian learningCBT approachMatching hypothesisFuture researchLack of researchLearningTesting of mechanismsAdaptive processInterventionMindfulnessDisordersAwarenessSkillsAcceptanceResearchEDHypothesisReward drinking and naltrexone treatment response among young adult heavy drinkers
Roos CR, Bold KW, Witkiewitz K, Leeman RF, DeMartini KS, Fucito LM, Corbin WR, Mann K, Kranzler HR, O'Malley SS. Reward drinking and naltrexone treatment response among young adult heavy drinkers. Addiction 2021, 116: 2360-2371. PMID: 33620746, PMCID: PMC8328878, DOI: 10.1111/add.15453.Peer-Reviewed Original ResearchIdentification and Validation of Distinct Latent Neurodevelopmental Profiles in the Adolescent Brain and Cognitive Development Study
Lichenstein SD, Roos C, Kohler R, Kiluk B, Carroll KM, Worhunsky PD, Witkiewitz K, Yip SW. Identification and Validation of Distinct Latent Neurodevelopmental Profiles in the Adolescent Brain and Cognitive Development Study. Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2021, 7: 352-361. PMID: 33706021, PMCID: PMC8426420, DOI: 10.1016/j.bpsc.2021.02.013.Peer-Reviewed Original ResearchConceptsAdolescent brainHigher emotion regulationCognitive Development StudyDevelopment of psychopathologyFunctional magnetic resonanceLow-reward groupLatent profile analysisEmotion regulationCognitive performanceDevelopmental subgroupsNeurodevelopmental profileSubgroup of individualsHigh rewardReward groupIdentified subgroupsNeurodevelopmental modelModerate groupNeurodevelopmental disordersPsychiatric riskMore screen timeCurrent studyDevelopmental profileNeural functionDevelopment studiesScreen timeA Bridge to Nowhere: Resistance to the Possibility of Some Heavy Drinking During Recovery and the Potential Public Health Implications
Witkiewitz K, Wilson AD, Pearson MR, Roos CR, Swan JE, Votaw VR, Stein ER, Edwards KA, Tonigan JS, Hallgren KA, Montes KS, Maisto SA, Tucker JA. A Bridge to Nowhere: Resistance to the Possibility of Some Heavy Drinking During Recovery and the Potential Public Health Implications. Journal Of Addiction Medicine 2021, 15: 352-353. PMID: 33577228, PMCID: PMC8352995, DOI: 10.1097/adm.0000000000000796.Peer-Reviewed Original Research
2020
Patterns of Transitions Between Relapse to and Remission From Heavy Drinking Over the First Year After Outpatient Alcohol Treatment and Their Relation to Long-Term Outcomes
Maisto SA, Hallgren KA, Roos CR, Swan JE, Witkiewitz K. Patterns of Transitions Between Relapse to and Remission From Heavy Drinking Over the First Year After Outpatient Alcohol Treatment and Their Relation to Long-Term Outcomes. Journal Of Consulting And Clinical Psychology 2020, 88: 1119-1132. PMID: 33370135, PMCID: PMC7900838, DOI: 10.1037/ccp0000615.Peer-Reviewed Original ResearchConceptsLong-term outcomesHeavy drinkingBetter long-term outcomesAlcohol use disorder treatmentRemission/relapsePattern of remissionOutpatient alcohol treatmentUse disorder treatmentFirst yearContinuous relapseContinuous remissionMore relapsesClinical courseOutpatient treatmentRemissionDrinking statusLong-term recoveryRelapsePosttreatment periodDisorder treatmentAlcohol treatmentRelapse episodesAverage durationFunctioning outcomesHeavy drinking statusAlexithymia and pain experience among patients using methadone-maintenance therapy
Morie KP, Potenza MN, Beitel M, Oberleitner LM, Roos CR, Yip SW, Oberleitner DE, Gaeta M, Barry DT. Alexithymia and pain experience among patients using methadone-maintenance therapy. Drug And Alcohol Dependence 2020, 218: 108387. PMID: 33168339, PMCID: PMC8103623, DOI: 10.1016/j.drugalcdep.2020.108387.Peer-Reviewed Original ResearchConceptsOpioid use disorderPain interferencePain acceptancePain experienceUse disordersMethadone maintenance therapySubset of patientsMethadone-treated patientsMethadone maintenance treatmentDrug use historyReporting painPain severityImportant intervention targetMaintenance treatmentMore painPain catastrophizingPainPatientsEffect of alexithymiaTreatment targetsDrug useIntervention targetsRole of alexithymiaRegression analysisSelf-report measuresCan Individuals With Alcohol Use Disorder Sustain Non-abstinent Recovery? Non-abstinent Outcomes 10 Years After Alcohol Use Disorder Treatment
Witkiewitz K, Wilson AD, Roos CR, Swan JE, Votaw VR, Stein ER, Pearson MR, Edwards KA, Tonigan JS, Hallgren KA, Montes KS, Maisto SA, Tucker JA. Can Individuals With Alcohol Use Disorder Sustain Non-abstinent Recovery? Non-abstinent Outcomes 10 Years After Alcohol Use Disorder Treatment. Journal Of Addiction Medicine 2020, 15: 303-310. PMID: 33060466, PMCID: PMC8044251, DOI: 10.1097/adm.0000000000000760.Peer-Reviewed Original ResearchEvaluating a Longitudinal Mediation Model of Perceived Stress, Depressive Symptoms, and Substance Use Treatment Outcomes
Roos CR, Kiluk BD, McHugh RK, Carroll KM. Evaluating a Longitudinal Mediation Model of Perceived Stress, Depressive Symptoms, and Substance Use Treatment Outcomes. Psychology Of Addictive Behaviors 2020, 34: 660-668. PMID: 32297754, PMCID: PMC7483283, DOI: 10.1037/adb0000581.Peer-Reviewed Original ResearchConceptsIllicit opioid useOpioid useDepressive symptomsUse disordersSubstance use outcomesMethadone treatmentStandard methadone treatmentTrial of galantamineUse outcomesOpioid use disorderSubstance Use Treatment OutcomesSubstance use disordersCocaine use disorderCognitive behavioral therapyLongitudinal treatment studyTreatment outcomesPredictors of endPosttreatment outcomesSymptomsTreatment studiesSignificant total effectSubstance useBaselineOutcomesDisordersAssociations Among Sleep Disturbance, Pain Catastrophizing, and Pain Intensity for Methadone-maintained Patients With Opioid Use Disorder and Chronic Pain
Martinez CP, Edwards KA, Roos CR, Beitel M, Eller A, Barry DT. Associations Among Sleep Disturbance, Pain Catastrophizing, and Pain Intensity for Methadone-maintained Patients With Opioid Use Disorder and Chronic Pain. The Clinical Journal Of Pain 2020, 36: 641-647. PMID: 32482968, PMCID: PMC7725378, DOI: 10.1097/ajp.0000000000000848.Peer-Reviewed Original ResearchConceptsOpioid use disorderMethadone maintenance treatmentChronic painPain intensitySleep disturbancesMMT patientsUse disordersLarge cross-sectional studyGreater pain intensityCo-occurring chronic painCross-sectional studyCross-sectional associationsGreater sleep disturbanceMaintenance treatmentPain catastrophizingPain issuesKey mechanistic pathwaysPainPatientsGreater painIntensity pathwaySignificant mediation effectSelf-report measuresDisordersAssociationShort- and long-term changes in substance-related coping as mediators of in-person and computerized CBT for alcohol and drug use disorders
Roos CR, Carroll KM, Nich C, Frankforter T, Kiluk BD. Short- and long-term changes in substance-related coping as mediators of in-person and computerized CBT for alcohol and drug use disorders. Drug And Alcohol Dependence 2020, 212: 108044. PMID: 32422538, PMCID: PMC7293942, DOI: 10.1016/j.drugalcdep.2020.108044.Peer-Reviewed Original ResearchConceptsCognitive behavioral therapyComputerized cognitive behavioral therapyPerson cognitive-behavioural therapySubstance use disordersMediation effectAlcohol use disorderComputer-delivered cognitive behavioural therapyUse disordersSame mediation effectSubstance-related copingCoping Strategies ScaleSignificant mediation effectMechanisms of changeMediational modelCoping skillsStrategies ScaleCBT4CBTStatistical mediatorCopingDrug use disordersSubstance useHeavy drinkingDisordersLong-term changesLong-term increase
2019
Clinical validation of reduction in cocaine frequency level as an endpoint in clinical trials for cocaine use disorder
Roos CR, Nich C, Mun CJ, Babuscio TA, Mendonca J, Miguel AQC, DeVito EE, Yip SW, Witkiewitz K, Carroll KM, Kiluk BD. Clinical validation of reduction in cocaine frequency level as an endpoint in clinical trials for cocaine use disorder. Drug And Alcohol Dependence 2019, 205: 107648. PMID: 31677490, PMCID: PMC6910212, DOI: 10.1016/j.drugalcdep.2019.107648.Peer-Reviewed Original ResearchAdvancing Precision Medicine for Alcohol Use Disorder: Replication and Extension of Reward Drinking as a Predictor of Naltrexone Response
Witkiewitz K, Roos CR, Mann K, Kranzler HR. Advancing Precision Medicine for Alcohol Use Disorder: Replication and Extension of Reward Drinking as a Predictor of Naltrexone Response. Alcohol Clinical And Experimental Research 2019, 43: 2395-2405. PMID: 31436886, PMCID: PMC6824945, DOI: 10.1111/acer.14183.Peer-Reviewed Original ResearchConceptsEffects of naltrexoneHeavy drinking daysAlcohol use disorderDaily naltrexoneUse disordersDrinking daysDaily drinkingPercent heavy drinking daysPrecision medicinePrecision medicine approachDaily medicationNaltrexone responseInteractive voice response technologyClinical trialsNaltrexone effectsRewarding effectsSpecific treatmentNaltrexoneSecondary analysisMedicine approachDrinkersProblem drinkersReward drinkersPlaceboDrinking