Endoplasmic reticulum stress sensitizes cells to DNA damage-induced apoptosis through p53-dependent suppression of p21CDKN1A
Mlynarczyk C, Fåhraeus R. Endoplasmic reticulum stress sensitizes cells to DNA damage-induced apoptosis through p53-dependent suppression of p21CDKN1A. Nature Communications 2014, 5: 5067. PMID: 25295585, DOI: 10.1038/ncomms6067.Peer-Reviewed Original ResearchConceptsCells to DNA damage-induced apoptosisER stressEndoplasmic reticulumDNA damage-induced apoptosisP53-dependent induction of p21G2 arrestDamage-induced apoptosisP53-induced apoptosisP53-dependent inductionDNA damageInduction of p21Endoplasmic reticulum stressCell cycle coordinationPromote G2 arrestP21 transcriptionP53 isoformsMRNA translationP53 pathwayG1 arrestGenotoxic drugsG2 checkpointReticulum stressSuppressing p21P53/47P53