Featured Publications
Endoplasmic reticulum stress sensitizes cells to DNA damage-induced apoptosis through p53-dependent suppression of p21CDKN1A
Mlynarczyk C, Fåhraeus R. Endoplasmic reticulum stress sensitizes cells to DNA damage-induced apoptosis through p53-dependent suppression of p21CDKN1A. Nature Communications 2014, 5: 5067. PMID: 25295585, DOI: 10.1038/ncomms6067.Peer-Reviewed Original ResearchConceptsCells to DNA damage-induced apoptosisER stressEndoplasmic reticulumDNA damage-induced apoptosisP53-dependent induction of p21G2 arrestDamage-induced apoptosisP53-induced apoptosisP53-dependent inductionDNA damageInduction of p21Endoplasmic reticulum stressCell cycle coordinationPromote G2 arrestP21 transcriptionP53 isoformsMRNA translationP53 pathwayG1 arrestGenotoxic drugsG2 checkpointReticulum stressSuppressing p21P53/47P53
2010
Endoplasmic Reticulum Stress Induces G2 Cell-Cycle Arrest via mRNA Translation of the p53 Isoform p53/47
Bourougaa K, Naski N, Boularan C, Mlynarczyk C, Candeias M, Marullo S, Fåhraeus R. Endoplasmic Reticulum Stress Induces G2 Cell-Cycle Arrest via mRNA Translation of the p53 Isoform p53/47. Molecular Cell 2010, 38: 78-88. PMID: 20385091, DOI: 10.1016/j.molcel.2010.01.041.Peer-Reviewed Original ResearchConceptsMRNA translationOutcome of p53 activationTrans-activation domainP53 downstream pathwaysMDM2 binding siteG2 cell cycle arrestCell cycle arrestEndoplasmic reticulum stressP53 isoformsP53/47P53 activationHomo-oligomerizationP53 pathwayG1 progressionTrans-activationCellular stressDNA repairG1 arrestBiochemical propertiesG2 arrestReticulum stressResponse to different typesDownstream pathwaysAmino acidsP53