Endoplasmic Reticulum Stress Induces G2 Cell-Cycle Arrest via mRNA Translation of the p53 Isoform p53/47
Bourougaa K, Naski N, Boularan C, Mlynarczyk C, Candeias M, Marullo S, Fåhraeus R. Endoplasmic Reticulum Stress Induces G2 Cell-Cycle Arrest via mRNA Translation of the p53 Isoform p53/47. Molecular Cell 2010, 38: 78-88. PMID: 20385091, DOI: 10.1016/j.molcel.2010.01.041.Peer-Reviewed Original ResearchConceptsMRNA translationOutcome of p53 activationTrans-activation domainP53 downstream pathwaysMDM2 binding siteG2 cell cycle arrestCell cycle arrestEndoplasmic reticulum stressP53 isoformsP53/47P53 activationHomo-oligomerizationP53 pathwayG1 progressionTrans-activationCellular stressDNA repairG1 arrestBiochemical propertiesG2 arrestReticulum stressResponse to different typesDownstream pathwaysAmino acidsP53