Featured Publications
Endoplasmic reticulum stress sensitizes cells to DNA damage-induced apoptosis through p53-dependent suppression of p21CDKN1A
Mlynarczyk C, Fåhraeus R. Endoplasmic reticulum stress sensitizes cells to DNA damage-induced apoptosis through p53-dependent suppression of p21CDKN1A. Nature Communications 2014, 5: 5067. PMID: 25295585, DOI: 10.1038/ncomms6067.Peer-Reviewed Original ResearchConceptsCells to DNA damage-induced apoptosisER stressEndoplasmic reticulumDNA damage-induced apoptosisP53-dependent induction of p21G2 arrestDamage-induced apoptosisP53-induced apoptosisP53-dependent inductionDNA damageInduction of p21Endoplasmic reticulum stressCell cycle coordinationPromote G2 arrestP21 transcriptionP53 isoformsMRNA translationP53 pathwayG1 arrestGenotoxic drugsG2 checkpointReticulum stressSuppressing p21P53/47P53
2022
Conformational transitions in BTG1 antiproliferative protein and their modulation by disease mutants
Kots E, Mlynarczyk C, Melnick A, Khelashvili G. Conformational transitions in BTG1 antiproliferative protein and their modulation by disease mutants. Biophysical Journal 2022, 121: 3753-3764. PMID: 35459639, PMCID: PMC9617077, DOI: 10.1016/j.bpj.2022.04.023.Peer-Reviewed Original ResearchConceptsB-cell translocation gene 1Antiproliferative proteinAssociate with transcriptional cofactorsFamily of antiproliferative proteinsWild-typeFunctional interactionsDisease-linked mutationsSomatic missense mutationsCell cycle progressionMarkov state model analysisConformational transitionBinding partnersTranscriptional cofactorCellular partnersCellular processesProtein regionsDisease mutantsMissense mutationsCycle progressionBinding hotspotsBinding proteinFunctional associationEnsemble of conformationsMolecular mechanismsA2-A4
2010
Endoplasmic Reticulum Stress Induces G2 Cell-Cycle Arrest via mRNA Translation of the p53 Isoform p53/47
Bourougaa K, Naski N, Boularan C, Mlynarczyk C, Candeias M, Marullo S, Fåhraeus R. Endoplasmic Reticulum Stress Induces G2 Cell-Cycle Arrest via mRNA Translation of the p53 Isoform p53/47. Molecular Cell 2010, 38: 78-88. PMID: 20385091, DOI: 10.1016/j.molcel.2010.01.041.Peer-Reviewed Original ResearchConceptsMRNA translationOutcome of p53 activationTrans-activation domainP53 downstream pathwaysMDM2 binding siteG2 cell cycle arrestCell cycle arrestEndoplasmic reticulum stressP53 isoformsP53/47P53 activationHomo-oligomerizationP53 pathwayG1 progressionTrans-activationCellular stressDNA repairG1 arrestBiochemical propertiesG2 arrestReticulum stressResponse to different typesDownstream pathwaysAmino acidsP53