Germinal center‐derived lymphomas: The darkest side of humoral immunity
Mlynarczyk C, Fontán L, Melnick A. Germinal center‐derived lymphomas: The darkest side of humoral immunity. Immunological Reviews 2019, 288: 214-239. PMID: 30874354, PMCID: PMC6518944, DOI: 10.1111/imr.12755.Peer-Reviewed Original ResearchConceptsB cellsGC reactionGerminal centersImmune receptor signalingBCL6 transcription factorTreated lymphoma patientsB-cell neoplasmsFunction of BCL6GC-derived lymphomasImmune regulatory mechanismsMutations of genesGC B cellsClonal diversityTranscription factorsBiological themesEpigenetic regulationGenomic lesionsPoint mutationsRegulatory mechanismsEpigenetic programmingLymphoma patientsOncogenic functionEpigenetic standpointTumor-suppressive effectsMutations