Conformational transitions in BTG1 antiproliferative protein and their modulation by disease mutants
Kots E, Mlynarczyk C, Melnick A, Khelashvili G. Conformational transitions in BTG1 antiproliferative protein and their modulation by disease mutants. Biophysical Journal 2022, 121: 3753-3764. PMID: 35459639, PMCID: PMC9617077, DOI: 10.1016/j.bpj.2022.04.023.Peer-Reviewed Original ResearchConceptsB-cell translocation gene 1Antiproliferative proteinAssociate with transcriptional cofactorsFamily of antiproliferative proteinsWild-typeFunctional interactionsDisease-linked mutationsSomatic missense mutationsCell cycle progressionMarkov state model analysisConformational transitionBinding partnersTranscriptional cofactorCellular partnersCellular processesProtein regionsDisease mutantsMissense mutationsCycle progressionBinding hotspotsBinding proteinFunctional associationEnsemble of conformationsMolecular mechanismsA2-A4