2022
Characterization of the COPD alveolar niche using single-cell RNA sequencing
Sauler M, McDonough JE, Adams TS, Kothapalli N, Barnthaler T, Werder RB, Schupp JC, Nouws J, Robertson MJ, Coarfa C, Yang T, Chioccioli M, Omote N, Cosme C, Poli S, Ayaub EA, Chu SG, Jensen KH, Gomez JL, Britto CJ, Raredon MSB, Niklason LE, Wilson AA, Timshel PN, Kaminski N, Rosas IO. Characterization of the COPD alveolar niche using single-cell RNA sequencing. Nature Communications 2022, 13: 494. PMID: 35078977, PMCID: PMC8789871, DOI: 10.1038/s41467-022-28062-9.Peer-Reviewed Original ResearchConceptsSingle-cell RNA sequencingRNA sequencingCell-specific mechanismsChronic obstructive pulmonary diseaseAdvanced chronic obstructive pulmonary diseaseTranscriptomic network analysisSingle-cell RNA sequencing profilesCellular stress toleranceAberrant cellular metabolismStress toleranceRNA sequencing profilesTranscriptional evidenceCellular metabolismAlveolar nicheSequencing profilesHuman alveolar epithelial cellsChemokine signalingAlveolar epithelial type II cellsObstructive pulmonary diseaseSitu hybridizationType II cellsEpithelial type II cellsSequencingCOPD pathobiologyHuman lung tissue samples
2021
MicroRNA miR-24-3p reduces DNA damage responses, apoptosis, and susceptibility to chronic obstructive pulmonary disease
Nouws J, Wan F, Finnemore E, Roque W, Kim SJ, Bazan IS, Li CX, Sköld C, Dai Q, Yan X, Chioccioli M, Neumeister V, Britto CJ, Sweasy J, Bindra RS, Wheelock ÅM, Gomez JL, Kaminski N, Lee PJ, Sauler M. MicroRNA miR-24-3p reduces DNA damage responses, apoptosis, and susceptibility to chronic obstructive pulmonary disease. JCI Insight 2021, 6: e134218. PMID: 33290275, PMCID: PMC7934877, DOI: 10.1172/jci.insight.134218.Peer-Reviewed Original ResearchConceptsCellular stress responseStress responseHomology-directed DNA repairDNA damage responseProtein BRCA1Damage responseCellular stressDNA repairProtein BimCOPD lung tissueLung epithelial cellsCellular responsesExpression arraysEpithelial cell apoptosisDNA damageChronic obstructive pulmonary diseaseBRCA1 expressionCell apoptosisApoptosisEpithelial cellsCritical mechanismMicroRNAsRegulatorObstructive pulmonary diseaseIncreases Susceptibility
2016
Respiratory Viral Infections in Chronic Lung Diseases
Britto CJ, Brady V, Lee S, Dela Cruz CS. Respiratory Viral Infections in Chronic Lung Diseases. Clinics In Chest Medicine 2016, 38: 87-96. PMID: 28159164, PMCID: PMC5679206, DOI: 10.1016/j.ccm.2016.11.014.Peer-Reviewed Original ResearchConceptsChronic lung diseaseChronic obstructive pulmonary diseaseInterstitial lung diseaseLung diseaseLung infectionViral infectionCystic fibrosisRespiratory viral infectionsObstructive pulmonary diseaseDifferent lung diseasesDisease exacerbationPulmonary diseaseDisease pathogenesisInfectionDiseaseAsthmaExacerbationPatientsFibrosisPathogenesisProgression
2015
Bactericidal/Permeability-Increasing Protein Fold–Containing Family Member A1 in Airway Host Protection and Respiratory Disease
Britto CJ, Cohn L. Bactericidal/Permeability-Increasing Protein Fold–Containing Family Member A1 in Airway Host Protection and Respiratory Disease. American Journal Of Respiratory Cell And Molecular Biology 2015, 52: 525-534. PMID: 25265466, PMCID: PMC4491141, DOI: 10.1165/rcmb.2014-0297rt.BooksConceptsPulmonary diseaseHost protectionChronic obstructive pulmonary diseaseObstructive pulmonary diseaseIdiopathic pulmonary fibrosisMember A1Immune cell functionMultiple lung diseasesBactericidal/permeability-increasing proteinRespiratory malignanciesPulmonary pathogenesisPulmonary fibrosisPermeability-increasing proteinRespiratory secretionsLung diseaseUpper airwayRespiratory tractRespiratory diseaseProximal tracheaImmunomodulatory propertiesBPIFA1Cystic fibrosisDiseasePotential drug targetsEnvironmental exposures