Autoimmune Hypocalciuric Hypercalcemia Unresponsive to Glucocorticoid Therapy in a Patient with Blocking Autoantibodies against the Calcium-Sensing Receptor
Pallais JC, Kemp EH, Bergwitz C, Kantham L, Slovik DM, Weetman AP, Brown EM. Autoimmune Hypocalciuric Hypercalcemia Unresponsive to Glucocorticoid Therapy in a Patient with Blocking Autoantibodies against the Calcium-Sensing Receptor. The Journal Of Clinical Endocrinology & Metabolism 2010, 96: 672-680. PMID: 21159843, PMCID: PMC3047232, DOI: 10.1210/jc.2010-1739.Peer-Reviewed Original ResearchMeSH KeywordsAgedAntibodies, AntinuclearAntibodies, BlockingAutoantibodiesAutoimmune DiseasesCalciumDrug ResistanceExtracellular Signal-Regulated MAP KinasesFemaleGlucocorticoidsHumansHypercalcemiaImmunoglobulin EImmunoprecipitationInositol PhosphatesParathyroid HormonePhosphorylationReceptors, Calcium-SensingStimulation, ChemicalType C PhospholipasesConceptsAutoimmune hypocalciuric hypercalcemiaUrinary calcium excretionCalcium-sensing receptorGlucocorticoid therapyGlucocorticoid treatmentPTH levelsCalcium excretionAutoantibody titersAccumulation of inositol-1-phosphateTrial of glucocorticoid therapyHypocalciuric hypercalcemiaEffect of extracellular Ca(2Regulation of PTH secretionSerum PTH levelsElevated PTH levelsInositol-1-phosphate accumulationPTH-mediated hypercalcemiaIonized calcium concentrationAntibody-mediated inhibitionExtracellular Ca(2PTH secretionBlocking autoantibodiesAutoimmune disordersSerum totalHypercalcemia