2019
Endocrine regulation of MFS2 by branchless controls phosphate excretion and stone formation in Drosophila renal tubules
Rose E, Lee D, Xiao E, Zhao W, Wee M, Cohen J, Bergwitz C. Endocrine regulation of MFS2 by branchless controls phosphate excretion and stone formation in Drosophila renal tubules. Scientific Reports 2019, 9: 8798. PMID: 31217461, PMCID: PMC6584732, DOI: 10.1038/s41598-019-45269-x.Peer-Reviewed Original ResearchConceptsDrosophila renal tubulesFly life spanGenetic ablationRNAi-mediated knockdownInorganic phosphate (Pi) homeostasisHigh-Pi mediumPi transportersAdult fliesControl of FGF signalingHigher speciesPi mediumInduces expressionMFS2FGF signalingExcretion of PiPhosphate homeostasisDrosophilaFly longevityEndocrine regulationHormone fibroblast growth factor 23Renal tubulesHormonal controlPi transportFibroblast growth factor 23Genetic overexpression
2009
Disorders of Phosphate Homeostasis and Tissue Mineralisation
Bergwitz C, Jüppner H. Disorders of Phosphate Homeostasis and Tissue Mineralisation. Endocrine Development 2009, 16: 133-156. PMID: 19494665, PMCID: PMC3810012, DOI: 10.1159/000223693.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsDisorders of phosphate homeostasisPhosphate homeostasisFibroblast growth factor 23Secretion of parathyroid hormoneAbnormal phosphate homeostasisDentin matrix protein 1Tissue mineralizationGrowth factor 23Co-receptor KlothoBone-kidney axisReabsorption of phosphateExpression of FGF23Renal proximal tubulesHomologies to endopeptidasesMatrix protein 1Phosphate-regulating geneCirculating phosphate concentrationClinical presentationFactor 23Parathyroid hormoneUDP-N-acetyl-alpha-D-galactosamineParathyroid glandsDiagnostic evaluationProximal tubulesD-galactosamine