Rapid desensitization of parathyroid hormone dependent adenylate cyclase in perifused human osteosarcoma cells (SaOS-2)
Bergwitz C, Abou-Samra A, Hesch R, Jüppner H. Rapid desensitization of parathyroid hormone dependent adenylate cyclase in perifused human osteosarcoma cells (SaOS-2). Biochimica Et Biophysica Acta 1994, 1222: 447-456. PMID: 8038214, DOI: 10.1016/0167-4889(94)90053-1.Peer-Reviewed Original ResearchConceptsApplication of parathyroid hormoneParathyroid hormonePTH(1-34CAMP releasePerifusion systemIncrease bone mass in vivoHormone-dependent adenylate cyclaseAdenylate cyclaseSaos-2 cellsReceptor internalizationPMA pre-treatmentDose-dependent increaseCyclic AMP accumulationBone mass in vivoStimulated cAMP accumulationHuman osteosarcoma cell line Saos-2Saos-2Osteosarcoma cell line Saos-2Cells in vitroMass in vivoBone massPerifusion experimentsBPTH(3-34Human osteosarcoma cellsHomologous desensitization