2018
Role of phosphate sensing in bone and mineral metabolism
Chande S, Bergwitz C. Role of phosphate sensing in bone and mineral metabolism. Nature Reviews Endocrinology 2018, 14: 637-655. PMID: 30218014, PMCID: PMC8607960, DOI: 10.1038/s41574-018-0076-3.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsPi transportersSignal transductionPi homeostasisCellular phosphate homeostasisPhosphate homeostasisExpression of Pi transportersPi-sensing mechanismEssential structural componentIntracellular signal transductionPi transportMulticellular organismsInositol pyrophosphatesIntracellular Pi levelsDomain proteinsRegulation of FGF23 expressionPlasma membranePhosphate sensingDisorders of phosphate homeostasisCell metabolismExtracellular matrixCellular levelHomeostasisTransductionGenetic disordersOrganisms
2012
Chapter 7 Phosphate Homeostasis Regulatory Mechanisms
Bergwitz C, Jüppner H. Chapter 7 Phosphate Homeostasis Regulatory Mechanisms. 2012, 141-161. DOI: 10.1016/b978-0-12-382040-2.10007-3.ChaptersRegulatory mechanismsBone-forming osteoblastsPi homeostasisMonocyte-macrophage lineage cellsBone-resorbing cellsPi concentrationMacrophage colony-stimulating factorSkeletal developmentFunction of chondrocytesExtracellular matrixLineage cellsMatrix productionOsteogenic cellsMajor functionColony-stimulating factorBone-resorbing osteoclastsPlasma Pi concentrationCellsOsteoblastsIntegral componentFunction of boneRate of bone growthAmbient Pi concentrationsMechanical supportHydroxyapatite crystals