2024
Both enantiomers of β-aminoisobutyric acid BAIBA regulate Fgf23 via MRGPRD receptor by activating distinct signaling pathways in osteocytes
Sakamoto E, Kitase Y, Fitt A, Zhu Z, Awad K, Brotto M, White K, Welc S, Bergwitz C, Bonewald L. Both enantiomers of β-aminoisobutyric acid BAIBA regulate Fgf23 via MRGPRD receptor by activating distinct signaling pathways in osteocytes. Cell Reports 2024, 43: 114397. PMID: 38935499, PMCID: PMC11350516, DOI: 10.1016/j.celrep.2024.114397.Peer-Reviewed Original ResearchActivate distinct signaling pathwaysSignaling pathwayFibroblast growth factor 23Urinary phosphate excretionReceptor type DInduce FGF23Urine phosphateElevated FGF23Phosphate excretionFGF23L-BAIBAExercise-induced increasePhosphate homeostasisSclerostinPhosphate metabolismReceptorsD-enantiomerBonePathway
2012
Dietary phosphate modifies lifespan in Drosophila
Bergwitz C. Dietary phosphate modifies lifespan in Drosophila. Nephrology Dialysis Transplantation 2012, 27: 3399-3406. PMID: 22942172, DOI: 10.1093/ndt/gfs362.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsImportant cellular processesNutrient-sensing pathwaysDrosophila melanogasterCellular processesLifespan extensionLarval developmentPhosphonoformic acidHuman disordersNormal fliesCellular uptakeSpecific pathwaysEffects of dietary phosphateDrosophilaReduced lifespanModel systemReduced cellular uptakeAdult lifespanLittle phosphateAbsorption of phosphatePathwayLifespanDietary phosphateTherapeutic approachesMelanogasterPowerful tool