2021
FGF23 signalling and physiology.
Ho BB, Bergwitz C. FGF23 signalling and physiology. Journal Of Molecular Endocrinology 2021, 66: r23-r32. PMID: 33338030, PMCID: PMC8782161, DOI: 10.1530/jme-20-0178.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsO-glycosylation of FGF23FGF23 signalingSubtilisin-like proprotein convertase furinSuppressing phosphate reabsorptionProprotein convertase furinPost-translationallyO-glycosylationIntact FGF23C-terminusGenetic activityPrevent proteolysisParacrine FGFsHigh-affinity binding sitesFibroblast growth factor 23Fruit flyActive intact FGF23Convertase furinChronic kidney diseaseFGF23 fragmentsGrowth factor 23Physiological roleEndocrine FGFsDihydroxyvitamin D synthesisHyperphosphatemic disordersIntestinal phosphate absorption
1991
Specific, high-affinity binding sites for angiotensin II on Mycoplasma hyorhinis
Bergwitz C, Madoff S, Abou-Samra A, Ju¨ppner H. Specific, high-affinity binding sites for angiotensin II on Mycoplasma hyorhinis. Biochemical And Biophysical Research Communications 1991, 179: 1391-1399. PMID: 1718269, DOI: 10.1016/0006-291x(91)91727-t.Peer-Reviewed Original ResearchConceptsAngiotensin II receptorsAngiotensin IIII receptorsHigh-affinity binding sitesAngiotensin II bindingOpossum kidney cellsCGP 42112ADuP 753Angiotensin IIIStrains of Mycoplasma hyorhinisAngiotensin IHuman angiotensin IIM. hominisHigh affinityKidney cellsBinding sitesII bindingMycoplasma hyorhinisSpecific bindingReceptorsStrains of M. hominisAntagonist DuP 753Fold decreaseSensitive to bacitracin