2016
Differential Expression of IR-A, IR-B and IGF-1R in Endometrial Physiology and Distinct Signature in Adenocarcinoma
Flannery CA, Saleh FL, Choe GH, Selen DJ, Kodaman PH, Kliman HJ, Wood TL, Taylor HS. Differential Expression of IR-A, IR-B and IGF-1R in Endometrial Physiology and Distinct Signature in Adenocarcinoma. The Journal Of Clinical Endocrinology & Metabolism 2016, 101: 2883-2891. PMID: 27088794, PMCID: PMC4929835, DOI: 10.1210/jc.2016-1795.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinomaAdultAntigens, CDCarcinoma, EndometrioidCells, CulturedEndometrial HyperplasiaEndometrial NeoplasmsEndometriumFemaleGene Expression ProfilingGene Expression Regulation, NeoplasticHumansMenstrual CycleMiddle AgedProtein SubunitsReceptor, IGF Type 1Receptor, InsulinTranscriptomeConceptsIGF-1R expressionEndometrial hyperplasiaNormal endometriumEndometrial physiologySecretory phaseProliferative phaseIGF-1 receptor mRNAIR-B expressionNormal secretory phaseType 2 diabetesSex steroid treatmentEarly secretory phaseEarly proliferative phaseNormal proliferative phaseEndometrial proliferationEndometrioid adenocarcinomaComplex hyperplasiaEndometrial adenocarcinomaMass indexMenstrual cycleRisk factorsReceptor expressionIGF-1RMAIN OUTCOMEReceptor mRNA
2014
mRNA-Binding Protein TIA-1 Reduces Cytokine Expression in Human Endometrial Stromal Cells and Is Down-Regulated in Ectopic Endometrium
Karalok HM, Aydin E, Saglam O, Torun A, Guzeloglu-Kayisli O, Lalioti MD, Kristiansson H, Duke CM, Choe G, Flannery C, Kallen CB, Seli E. mRNA-Binding Protein TIA-1 Reduces Cytokine Expression in Human Endometrial Stromal Cells and Is Down-Regulated in Ectopic Endometrium. The Journal Of Clinical Endocrinology & Metabolism 2014, 99: e2610-e2619. PMID: 25140393, PMCID: PMC4255110, DOI: 10.1210/jc.2013-3488.Peer-Reviewed Original ResearchConceptsHuman endometrial stromal cellsTNF-α expressionTIA-1 expressionEndometrial stromal cellsIL-6Pathogenesis of endometriosisMenstrual cycleTIA-1Endometrial tissueEctopic endometriumImmune factorsHistological scoresCultured human endometrial stromal cellsSteroid hormonesStromal cellsGrowth factorElevated IL-6Ectopic endometrial tissueNormal menstrual cycleEutopic endometrial tissuesGrowth factor expressionT-cell intracellular antigenEndometrial cytokinesEndometrial functionControl women