2017
Human LACC1 increases innate receptor-induced responses and a LACC1 disease-risk variant modulates these outcomes
Lahiri A, Hedl M, Yan J, Abraham C. Human LACC1 increases innate receptor-induced responses and a LACC1 disease-risk variant modulates these outcomes. Nature Communications 2017, 8: 15614. PMID: 28593945, PMCID: PMC5472760, DOI: 10.1038/ncomms15614.Peer-Reviewed Original ResearchMeSH KeywordsBacteriaCells, CulturedCrohn DiseaseCytokinesElectron Transport Complex IIExtracellular Signal-Regulated MAP KinasesHumansImmunity, InnateIntracellular Signaling Peptides and ProteinsJNK Mitogen-Activated Protein KinasesMacrophagesNF-kappa BNod2 Signaling Adaptor ProteinP38 Mitogen-Activated Protein KinasesProteinsReactive Oxygen SpeciesReceptors, Pattern RecognitionRNA InterferenceRNA, Small InterferingSuccinate DehydrogenaseConceptsBacterial clearanceCytokine secretionDisease risk variantsReceptor-induced responsesMyeloid-derived cellsNOD2 stimulationRecognition receptorsHuman macrophagesSuccinate dehydrogenaseMtROS productionMitochondrial ROS productionROS productionOutcomesSDH activityMacrophagesSecretionFunctional consequencesClearanceLACC1PRRImportant contributorCellsDisease-associated lociReceptors
2015
Twist1 and Twist2 Contribute to Cytokine Downregulation following Chronic NOD2 Stimulation of Human Macrophages through the Coordinated Regulation of Transcriptional Repressors and Activators
Zheng S, Hedl M, Abraham C. Twist1 and Twist2 Contribute to Cytokine Downregulation following Chronic NOD2 Stimulation of Human Macrophages through the Coordinated Regulation of Transcriptional Repressors and Activators. The Journal Of Immunology 2015, 195: 217-226. PMID: 26019273, PMCID: PMC4501480, DOI: 10.4049/jimmunol.1402808.Peer-Reviewed Original ResearchMeSH KeywordsAcetylmuramyl-Alanyl-IsoglutamineActivating Transcription Factor 4Antibodies, NeutralizingCCAAT-Enhancer-Binding ProteinsCore Binding Factor Alpha 1 SubunitCore Binding Factor Alpha 2 SubunitGene Expression RegulationHumansInterleukin-10Macrophage ActivationMacrophagesNod2 Signaling Adaptor ProteinNuclear ProteinsPolycomb Repressive Complex 1Primary Cell CulturePromoter Regions, GeneticProtein BindingProto-Oncogene Proteins c-mafRepressor ProteinsRNA, Small InterferingSignal TransductionTranscription, GeneticTransforming Growth Factor betaTwist-Related Protein 1ConceptsChronic NOD2 stimulationCytokine downregulationNOD2 stimulationTwist2 expressionHuman macrophagesTGF-β dependentIntestinal immune homeostasisC-MafOligomerization domain 2IL-10Intestinal macrophagesImmune homeostasisTranscription factor 4PRR stimulationAcute stimulationDecreased expressionMacrophagesBMI1 expressionCytokinesNOD2StimulationTwist1DownregulationTranscriptional repressor Bmi1Factor 4
2013
NF-κB1 Inhibits NOD2-Induced Cytokine Secretion through ATF3-Dependent Mechanisms
Zheng S, Abraham C. NF-κB1 Inhibits NOD2-Induced Cytokine Secretion through ATF3-Dependent Mechanisms. Molecular And Cellular Biology 2013, 33: 4857-4871. PMID: 24100018, PMCID: PMC3889551, DOI: 10.1128/mcb.00797-13.Peer-Reviewed Original ResearchMeSH KeywordsActivating Transcription Factor 3AnimalsCells, CulturedCytokinesEpigenesis, GeneticGene Knockdown TechniquesHistonesHumansIleumMacrophagesMiceMice, Inbred C57BLMice, KnockoutNF-kappa B p50 SubunitNod1 Signaling Adaptor ProteinNod2 Signaling Adaptor ProteinPrimary Cell CulturePromoter Regions, GeneticProtein Processing, Post-TranslationalToll-Like Receptor 2Toll-Like Receptor 4Transcriptional ActivationConceptsChronic NOD2 stimulationIntestinal immune homeostasisCytokine secretionNOD2 stimulationNF-κB1Immune homeostasisHuman macrophagesNF-κB pathwayNF-κB1 expressionCytokine downregulationInhibitory pathwaysNOD2ATF3 expressionSecretionIntestinal environmentGene promoterCytokine gene promotersStimulationInhibitory histone modificationsATF3MacrophagesKnockdown conditionsCritical mechanismHomeostasisCytokines