2022
Membrane attack complexes, endothelial cell activation, and direct allorecognition
Song G, Wang S, Barkestani MN, Mullan C, Fan M, Jiang B, Jiang Q, Li X, Jane-wit D. Membrane attack complexes, endothelial cell activation, and direct allorecognition. Frontiers In Immunology 2022, 13: 1020889. PMID: 36211400, PMCID: PMC9539657, DOI: 10.3389/fimmu.2022.1020889.Peer-Reviewed Original ResearchConceptsAntibody-mediated rejectionIschemia-reperfusion injuryDonor-derived endothelial cellsAlloreactive T cellsT cellsDirect allorecognitionInflammatory mediatorsMembrane attack complexEndothelial cellsTissue allograftsCell activationEC activationComplement cascadeAlloimmune T cell responsesT cell-mediated inflammationSolid organ transplant rejectionCell-mediated inflammationRecipient T cellsSolid organ transplantationT cell infiltrationT cell responsesDonor endothelial cellsImmune cell activationEndothelial cell activationOrgan transplant rejection
2015
Broad Blockade Antibody Responses in Human Volunteers after Immunization with a Multivalent Norovirus VLP Candidate Vaccine: Immunological Analyses from a Phase I Clinical Trial
Lindesmith LC, Ferris MT, Mullan CW, Ferreira J, Debbink K, Swanstrom J, Richardson C, Goodwin RR, Baehner F, Mendelman PM, Bargatze RF, Baric RS. Broad Blockade Antibody Responses in Human Volunteers after Immunization with a Multivalent Norovirus VLP Candidate Vaccine: Immunological Analyses from a Phase I Clinical Trial. PLOS Medicine 2015, 12: e1001807. PMID: 25803642, PMCID: PMC4371888, DOI: 10.1371/journal.pmed.1001807.Peer-Reviewed Original ResearchConceptsTime of vaccinationAb responsesVLP vaccineHuman volunteersProtective immunityAb titersCandidate vaccinesEffective NoV vaccinesPhase I ClinicalCross-strain protectionSurrogate neutralization assayBlockade antibodiesAb blockadeNoV infectionBlockade assayAcute gastroenteritisImmune responseNeutralization assaysNoV vaccinesVaccine componentsPredominant GIIMultiple epitopesVaccinationPrevious exposure historyAntigenic drift