2022
Clinical implications of Type 2 diabetes on outcomes after cardiac transplantation
Chouairi F, Mullan C, Ahmed A, Bhinder J, Guha A, Miller P, Jastreboff A, Fuery M, Chiravuri M, Geirsson A, Desai N, Maulion C, Sen S, Ahmad T, Anwer M. Clinical implications of Type 2 diabetes on outcomes after cardiac transplantation. PLOS ONE 2022, 17: e0273111. PMID: 36516178, PMCID: PMC9750001, DOI: 10.1371/journal.pone.0273111.Peer-Reviewed Original ResearchMeSH KeywordsDiabetes Mellitus, Type 2FemaleHeart FailureHeart TransplantationHumansMaleProportional Hazards ModelsRetrospective StudiesWaiting ListsConceptsPost-transplant mortalityType 2 diabetesAllocation system changeOld allocation systemsHeart transplant recipientsOutcomes of patientsOrgan Sharing databaseProportion of patientsHeart transplantation outcomesLower likelihoodLikelihood of transplantationHigher likelihoodNew allocation systemCardiac transplantationHeart transplantationTransplant recipientsT2D patientsHeart failureSharing databaseCox regressionTransplantation outcomesUnited NetworkWorse outcomesT2DPatientsInstitution representation in publications reporting mitral valve repair durability: A scoping review
Komlo CM, Brooks C, Amabile A, Mori M, Najem M, Mullan C, Weininger G, Krane M, Vallabhajosyula P, Geirsson A. Institution representation in publications reporting mitral valve repair durability: A scoping review. Journal Of Cardiac Surgery 2022, 37: 2163-2165. PMID: 35506749, DOI: 10.1111/jocs.16498.Peer-Reviewed Original Research
2021
Trends and Outcomes of Cardiac Transplantation in the Lowest Urgency Candidates
Fuery MA, Chouairi F, Natov P, Bhinder J, Rose Chiravuri M, Wilson L, Clark KA, Reinhardt SW, Mullan C, Miller PE, Davis RP, Rogers JG, Patel CB, Sen S, Geirsson A, Anwer M, Desai N, Ahmad T. Trends and Outcomes of Cardiac Transplantation in the Lowest Urgency Candidates. Journal Of The American Heart Association 2021, 10: e023662. PMID: 34743559, PMCID: PMC9075266, DOI: 10.1161/jaha.121.023662.Peer-Reviewed Original ResearchMeSH KeywordsDatabases, FactualFemaleHeart TransplantationHumansMaleRetrospective StudiesSurvival AnalysisTissue DonorsTreatment OutcomeWaiting ListsConceptsLow-urgency patientsHigh-urgency patientsUrgency patientsCardiac transplantationAllocation system changeLonger waitlist timesOrgan Sharing databaseTime of transplantationCardiac transplantation candidatesNew allocation systemBaseline recipientPosttransplantation outcomesPosttransplantation survivalAdditional comorbiditiesClinical characteristicsConclusions PatientsHepatitis CIschemic timeTransplantation candidatesSharing databaseWaitlist timeWaitlist survivalUnited NetworkRetrospective analysisPatientsBrief report: Cannabis and opioid use disorder among heart failure admissions, 2008–2018
Chouairi F, Mullan CW, Ravindra N, Clark KAA, Jaffe EM, Bhinder J, Fuery M, Guha A, Ahmad T, Desai NR. Brief report: Cannabis and opioid use disorder among heart failure admissions, 2008–2018. PLOS ONE 2021, 16: e0255514. PMID: 34591847, PMCID: PMC8483306, DOI: 10.1371/journal.pone.0255514.Peer-Reviewed Original ResearchTrends in transcatheter and surgical aortic valve replacement in the United States, 2008-2018
Clark KA, Chouairi F, Kay B, Reinhardt SW, Miller PE, Fuery M, Mullan CW, Guha A, Ahmad T, Desai NR. Trends in transcatheter and surgical aortic valve replacement in the United States, 2008-2018. American Heart Journal 2021, 243: 87-91. PMID: 34571040, DOI: 10.1016/j.ahj.2021.03.017.Peer-Reviewed Original ResearchMechanical ventilation at the time of heart transplantation and associations with clinical outcomes
Miller PE, Mullan CW, Chouairi F, Sen S, Clark KA, Reinhardt S, Fuery M, Anwer M, Geirsson A, Formica R, Rogers JG, Desai NR, Ahmad T. Mechanical ventilation at the time of heart transplantation and associations with clinical outcomes. European Heart Journal Acute Cardiovascular Care 2021, 10: 843-851. PMID: 34389855, PMCID: PMC8557439, DOI: 10.1093/ehjacc/zuab063.Peer-Reviewed Original ResearchMeSH KeywordsAdultDatabases, FactualHeart TransplantationHumansLogistic ModelsOdds RatioRespiration, ArtificialRetrospective StudiesConceptsHeart transplantationMechanical ventilationSingle-organ heart transplantationMedian waitlist timeOrgan Sharing databaseTime of transplantationMultivariable logistic regressionMultivariable adjustmentWaitlist timeClinical outcomesSharing databasePoor outcomeVentilated patientsUnited NetworkTemporary mechanical supportClinical acuityTransplantationPatientsPrevious dialysisLogistic regressionMortalityStrong associationReasonable outcomesOutcomesAssociationRelationship of surgeon experience and outcomes of surgery for degenerative mitral valve disease
Yousef S, Singh S, Mullan CW, Dey P, Mori M, Brooks C, Bin Mahmood SU, Hashim S, Vallabhajosyula P, Geirsson A. Relationship of surgeon experience and outcomes of surgery for degenerative mitral valve disease. Journal Of Cardiac Surgery 2021, 36: 2621-2627. PMID: 33896034, DOI: 10.1111/jocs.15583.Peer-Reviewed Original ResearchConceptsDegenerative mitral valve diseaseMitral valve diseaseValve diseaseSurgeon experienceExperienced surgeonsShorter cross-clamp timeCox proportional hazards methodCross-clamp timeWorse comorbidity profileIndependent risk factorMitral valve surgeryOutcome of surgeryKaplan-Meier curvesMitral regurgitation recurrenceProportional hazards methodsOperations/yearValve surgeryEmergent operationMeier curvesPatient characteristicsRegurgitation recurrenceComorbidity profilesRisk factorsSevere MRHazards methodsChanges in Use of Left Ventricular Assist Devices as Bridge to Transplantation With New Heart Allocation Policy
Mullan CW, Chouairi F, Sen S, Mori M, Clark KAA, Reinhardt SW, Miller PE, Fuery MA, Jacoby D, Maulion C, Anwer M, Geirsson A, Mulligan D, Formica R, Rogers JG, Desai NR, Ahmad T. Changes in Use of Left Ventricular Assist Devices as Bridge to Transplantation With New Heart Allocation Policy. JACC Heart Failure 2021, 9: 420-429. PMID: 33714748, DOI: 10.1016/j.jchf.2021.01.010.Peer-Reviewed Original ResearchMeSH KeywordsAdultHeart FailureHeart TransplantationHeart-Assist DevicesHumansPolicyRetrospective StudiesTissue DonorsTreatment OutcomeUnited StatesWaiting ListsConceptsDonor heart allocation systemNumber of patientsHeart allocation systemVentricular assist deviceWaitlist survivalAssist deviceNew heart allocation policyLeft ventricular assist deviceAllocation system changePost-transplant mortalityOrgan Sharing databaseOutcomes of patientsPost-transplantation outcomesProportion of patientsTime of transplantContinuous-flow LVADPost-transplantation survivalHeart allocation policyNew allocation systemBaseline recipientStatus 1AHeart transplantationIschemic timeLVAD implantationTransplant listImpact of chronic lung disease on quality‐of‐life outcomes in patients undergoing transcatheter aortic valve replacement
Catalano MA, Lin D, Mullan CW, Cassiere H, Rutkin B, Maurer G, Berg J, Hartman A, Yu P. Impact of chronic lung disease on quality‐of‐life outcomes in patients undergoing transcatheter aortic valve replacement. Journal Of Cardiac Surgery 2021, 36: 672-677. PMID: 33403744, DOI: 10.1111/jocs.15248.Peer-Reviewed Original ResearchConceptsTranscatheter aortic valve replacementChronic lung diseaseAortic valve replacementAortic stenosisLung diseaseValve replacementKansas City Cardiomyopathy Questionnaire-12Concomitant severe aortic stenosisLower baseline ejection fractionPreoperative pulmonary function testsSTS Predicted RiskSevere aortic stenosisBaseline ejection fractionPeripheral artery diseasePulmonary function testsObstructive lung diseaseSignificant differencesKCCQ-12TAVR patientsPostoperative outcomesSymptomatic improvementArtery diseaseEjection fractionRetrospective reviewFunction tests
2020
Clinical implications of differences between real world and clinical trial usage of left ventricular assist devices for end stage heart failure
Mezzacappa C, Ravindra NG, Caraballo C, Chouairi F, Miller PE, Clarke JD, Gruen J, Mori M, McCullough M, Mullan C, Geirsson A, Rogers JG, Anwer M, Desai N, Ahmad T. Clinical implications of differences between real world and clinical trial usage of left ventricular assist devices for end stage heart failure. PLOS ONE 2020, 15: e0242928. PMID: 33270648, PMCID: PMC7714148, DOI: 10.1371/journal.pone.0242928.Peer-Reviewed Original ResearchConceptsClinical trialsVentricular assist deviceExclusion criteriaLVAD recipientsAssist deviceReal-world settingClinical implicationsClinical trial exclusion criteriaHeart failure clinical trialsEnd-stage renal diseaseEnd-stage heart failureReal-world registryRetrospective cohort studyLandmark clinical trialsStage renal diseaseTrial exclusion criteriaRisk of deathStage heart failureRespiratory failureCohort studyPatient characteristicsHeart failurePatient factorsRenal diseaseClinical outcomesTransition to Advanced Therapies in Elderly Patients Supported by Extracorporeal Membrane Oxygenation Therapy
Chouairi F, Vallabhajosyula S, Mullan C, Mori M, Geirsson A, Desai NR, Ahmad T, Miller PE. Transition to Advanced Therapies in Elderly Patients Supported by Extracorporeal Membrane Oxygenation Therapy. Journal Of Cardiac Failure 2020, 26: 1086-1089. PMID: 32777479, DOI: 10.1016/j.cardfail.2020.07.019.Peer-Reviewed Original ResearchMeSH KeywordsAgedExtracorporeal Membrane OxygenationHeart FailureHeart TransplantationHeart-Assist DevicesHumansRetrospective StudiesShock, CardiogenicTreatment OutcomeConceptsExtracorporeal membrane oxygenationOrthotopic cardiac transplantationCardiogenic shockAdvanced therapiesVentricular assist device implantationNational Inpatient Sample databaseExtracorporeal membrane oxygenation therapyYounger groupStudy periodAssist device implantationMembrane oxygenation therapyProportion of patientsSurvival of patientsHospitalizations of peopleOlder age groupsHospital mortalityCardiac transplantationECMO supportMultivariable adjustmentElderly patientsLVAD implantationMembrane oxygenationOxygenation therapyPrimary outcomeDevice implantationUnited States national trends in comorbidity and outcomes of adult cardiac surgery patients
Mullan CW, Mori M, Pichert MD, Bin Mahmood SU, Yousef S, Geirsson A. United States national trends in comorbidity and outcomes of adult cardiac surgery patients. Journal Of Cardiac Surgery 2020, 35: 2248-2253. PMID: 33448476, DOI: 10.1111/jocs.14764.Peer-Reviewed Original ResearchConceptsMitral valve repair/replacementAortic valve replacementCardiac surgery patientsHospital mortalityLength of staySurgery patientsCardiac surgeryAdult cardiac surgery patientsAdult cardiac surgery proceduresUnited States national trendsValve repair/replacementICD-9 procedure codesCoronary artery bypassCardiac surgery proceduresType of surgeryNational Inpatient SampleICD-9 codesNational trendsCross-sectional analysisCABG/Comorbidity trendsArtery bypassPatient ageValve replacementComorbidity profilesSex Differences in Patients Receiving Left Ventricular Assist Devices for End-Stage Heart Failure
Gruen J, Caraballo C, Miller PE, McCullough M, Mezzacappa C, Ravindra N, Mullan CW, Reinhardt SW, Mori M, Velazquez E, Geirsson A, Ahmad T, Desai NR. Sex Differences in Patients Receiving Left Ventricular Assist Devices for End-Stage Heart Failure. JACC Heart Failure 2020, 8: 770-779. PMID: 32653446, DOI: 10.1016/j.jchf.2020.04.015.Peer-Reviewed Original ResearchMeSH KeywordsAgedFemaleHeart FailureHeart TransplantationHeart-Assist DevicesHumansMaleRegistriesRetrospective StudiesSex CharacteristicsTreatment OutcomeConceptsAdverse eventsVentricular assist deviceClinical outcomesPotential underuseHigh riskAssist deviceEnd-stage heartWomen 65 yearsRisk of deathContinuous-flow LVADYears of ageAdvanced treatment optionsSex differencesHeart transplantationMultivariable adjustmentHeart failureHeart transplantSimilar incidenceTreatment optionsSimilar riskSurvival analysisLVADPatientsDevice malfunctionWomenClinical impact of concomitant tricuspid valve procedures during left ventricular assist device implantation
Mullan C, Caraballo C, Ravindra NG, Miller PE, Mori M, McCullough M, Clarke JD, Anwer M, Velazquez EJ, Geirsson A, Desai NR, Ahmad T. Clinical impact of concomitant tricuspid valve procedures during left ventricular assist device implantation. The Journal Of Heart And Lung Transplantation 2020, 39: 926-933. PMID: 32593561, DOI: 10.1016/j.healun.2020.05.007.Peer-Reviewed Original ResearchConceptsConcomitant tricuspid valve proceduresTricuspid valve proceduresSevere tricuspid regurgitationTricuspid regurgitationLVAD implantationValve proceduresLeft ventricular assist device implantationVentricular assist device implantationDegree of TREnd-stage heart failureAssist device implantationRisk of bleedingCases of mildContinuous-flow LVADVentricular assist deviceInteragency RegistryAdult patientsAdverse eventsSurvival benefitHeart failureClinical outcomesDevice implantationTR severityQOL outcomesClinical impactModern Treatment Trends and Outcomes of Pulmonary Embolism With and Without Hemodynamic Significance
Mullan CW, Newman J, Geib M, Pichert MD, Saffarzadeh A, Hartman A, Lima B. Modern Treatment Trends and Outcomes of Pulmonary Embolism With and Without Hemodynamic Significance. The Annals Of Thoracic Surgery 2020, 110: 1534-1540. PMID: 32224241, DOI: 10.1016/j.athoracsur.2020.02.041.Peer-Reviewed Original ResearchConceptsCatheter-directed therapyPulmonary embolismSaddle embolismHospital deathSurgical embolectomySystemic thrombolyticsMembrane oxygenationSaddle pulmonary embolismExtracorporeal membrane oxygenationNational Inpatient SampleNational trendsSystemic thrombolysisPulmonary embolectomyRevision codesInpatient SampleHemodynamic significanceEmbolectomyTreatment trendsEmbolismInternational ClassificationLogistic regressionPopulation-level outcomesTherapyDeathThrombolyticsIncidence and characteristics of hospitalization for proximal aortic surgery for acute syndromes and for aneurysms in the USA from 2005 to 2014
Mullan CW, Mori M, Bin Mahmood SU, Yousef S, Mangi AA, Elefteriades JA, Geirsson A. Incidence and characteristics of hospitalization for proximal aortic surgery for acute syndromes and for aneurysms in the USA from 2005 to 2014. European Journal Of Cardio-Thoracic Surgery 2020, 58: 583-589. PMID: 32163136, DOI: 10.1093/ejcts/ezaa067.Peer-Reviewed Original ResearchMeSH KeywordsAortic Aneurysm, ThoracicAortic DissectionHospitalizationHumansIncidenceRetrospective StudiesSyndromeUnited StatesConceptsAcute aortic syndromeProximal aortic surgeryAortic aneurysm surgeryAortic syndromeAneurysm surgeryAortic surgeryThoracic aortic aneurysm surgeryThoracic aneurysm surgeryNational Inpatient SampleCharacteristics of hospitalizationsEdition diagnosis codesAneurysm populationAneurysm operationsAortic proceduresCardiopulmonary bypassAcute syndromeBlack patientsCardiac operationsDiagnosis codesHospital characteristicsInpatient SampleSociodemographic disparitiesSurgical volumeRetrospective analysisCase volumeCombined Valve Operations in the Aortic and Mitral Positions With or Without Added Tricuspid Valve Repair
Faggion Vinholo T, Mori M, Mahmood SUB, Mullan CW, Weininger G, Yousef S, Geirsson A. Combined Valve Operations in the Aortic and Mitral Positions With or Without Added Tricuspid Valve Repair. Seminars In Thoracic And Cardiovascular Surgery 2020, 32: 665-672. PMID: 32060011, DOI: 10.1053/j.semtcvs.2020.02.010.Peer-Reviewed Original ResearchConceptsDouble valve surgeryPerioperative adverse eventsTricuspid valve repairTricuspid regurgitationValve surgeryAdverse eventsValve repairMitral valveMitral positionValve functionTriple valve surgeryMid-term survivalLimited clinical evidenceSingle-institution seriesSubpopulation of patientsTricuspid valve functionMitral valve diseaseValve operationsLogistic regression modelsSignificant additional riskMultivalve surgeryPostoperative echocardiogramsPatient comorbiditiesMultivariable analysisClinical evidence
2019
Clinical significance of presenting syndromes on outcome after coronary artery bypass grafting
Bin Mahmood SU, Mori M, Yousef S, Mullan CW, Mangi AA, Geirsson A. Clinical significance of presenting syndromes on outcome after coronary artery bypass grafting. Interdisciplinary CardioVascular And Thoracic Surgery 2019, 30: 243-248. PMID: 31713612, DOI: 10.1093/icvts/ivz259.Peer-Reviewed Original ResearchConceptsAcute coronary syndromeStable ischemic heart diseaseCox proportional hazards modelCoronary artery bypassMid-term survivalIschemic heart diseaseProportional hazards modelPresenting syndromeArtery bypassHeart diseaseHazards modelMortality rateMultivariable Cox proportional hazards modelsMultivariate Cox proportional hazards modelMid-term mortality ratesSingle-center retrospective studyConsecutive CABG operationsMid-term mortalityCongestive heart failurePost-discharge survivalLong-term followIntensive care unitOverall mean durationMore comorbiditiesCABG operationsPediatric thymectomy: a study of national trends in demographics, short-term outcomes, and cost
Catalano MA, Mullan CW, Rich BS, Glick RD. Pediatric thymectomy: a study of national trends in demographics, short-term outcomes, and cost. Pediatric Surgery International 2019, 35: 749-757. PMID: 31119357, DOI: 10.1007/s00383-019-04486-1.Peer-Reviewed Original ResearchConceptsShort-term outcomesMyasthenia gravisRetrospective cross-sectional analysisOverall morbidity rateShorter hospital staySingle-institution cohortHospital discharge recordsLength of stayCross-sectional analysisMethodsThe KidsHospital deathHospital stayRespiratory complicationsPatient characteristicsCommon indicationLow morbidityPediatric patientsPediatric populationThymic neoplasmsHispanic raceInpatient DatabaseMorbidity rateMore complicationsSurgical approachRisk factorsUS National Trends in the Management and Outcomes of Constrictive Pericarditis: 2005-2014
Mori M, Mullan CW, Bin Mahmood SU, Yousef S, Pelletier KJ, Mangi AA, Geirsson A. US National Trends in the Management and Outcomes of Constrictive Pericarditis: 2005-2014. Canadian Journal Of Cardiology 2019, 35: 1394-1399. PMID: 31493971, DOI: 10.1016/j.cjca.2019.05.015.Peer-Reviewed Original ResearchConceptsConstrictive pericarditisPatient characteristicsNational Inpatient Sample datasetHospital mortality rateOutcomes of patientsProportion of patientsCardiopulmonary bypass useUS national trendsUse of CPBUS Census population estimatesCensus population estimatesPoisson regression modelsCPB useHospital mortalityOperative mortalityComorbid patientsSurgical managementBypass usePericarditisMortality ratePatientsPericardiectomyCohortNational trendsMortality