Evidence for phospholipid export from the bacterial inner membrane by the Mla ABC transport system
Hughes G, Hall S, Laxton C, Sridhar P, Mahadi A, Hatton C, Piggot T, Wotherspoon P, Leney A, Ward D, Jamshad M, Spana V, Cadby I, Harding C, Isom G, Bryant J, Parr R, Yakub Y, Jeeves M, Huber D, Henderson I, Clifton L, Lovering A, Knowles T. Evidence for phospholipid export from the bacterial inner membrane by the Mla ABC transport system. Nature Microbiology 2019, 4: 1692-1705. PMID: 31235958, DOI: 10.1038/s41564-019-0481-y.Peer-Reviewed Original ResearchConceptsMla pathwayInner membraneAsymmetric Gram-negative outer membranePhospholipid transportRetrograde phospholipid transportGram-negative outer membranePhospholipid-binding pocketABC transport systemSoluble periplasmic proteinBacterial inner membraneInner membrane ATPaseIndependent of ATPClosed apo conformationPhospholipid exportPeriplasmic proteinsMlaFEDB complexOuter membraneApo formApo conformationLipid exportMembrane ATPaseExport processPathwayMembraneMLAC