2021
Age-Dependent Heterogeneity in the Efficacy of Prophylaxis With Enoxaparin Against Catheter-Associated Thrombosis in Critically Ill Children: A Post Hoc Analysis of a Bayesian Phase 2b Randomized Clinical Trial.
Faustino EVS, Raffini LJ, Hanson SJ, Cholette JM, Pinto MG, Li S, Kandil SB, Nellis ME, Shabanova V, Silva CT, Tala JA, McPartland T, Spinella PC. Age-Dependent Heterogeneity in the Efficacy of Prophylaxis With Enoxaparin Against Catheter-Associated Thrombosis in Critically Ill Children: A Post Hoc Analysis of a Bayesian Phase 2b Randomized Clinical Trial. Critical Care Medicine 2021, 49: e369-e380. PMID: 33566465, PMCID: PMC7979442, DOI: 10.1097/ccm.0000000000004848.Peer-Reviewed Original ResearchConceptsCentral venous catheter-associated deep venous thrombosisCatheter-associated deep venous thrombosisCentral venous cathetersEfficacy of prophylaxisDeep venous thrombosisAge-dependent heterogeneityAnti-Xa levelsVenous cathetersVenous thrombosisFactor VIII activityThrombin generationPlatelet countClinical trialsIll childrenPhase 2bVIII activityLow factor VIII activityCatheter-Associated ThrombosisInternational units/mLMinimum platelet countOlder childrenCritically Ill ChildrenEndogenous thrombin potentialHigher platelet countsPost Hoc Analysis
2020
Efficacy of Early Prophylaxis Against Catheter-Associated Thrombosis in Critically Ill Children: A Bayesian Phase 2b Randomized Clinical Trial.
Faustino EVS, Shabanova V, Raffini LJ, Kandil SB, Li S, Pinto MG, Cholette JM, Hanson SJ, Nellis ME, Silva CT, Chima R, Sharathkumar A, Thomas KA, McPartland T, Tala JA, Spinella PC. Efficacy of Early Prophylaxis Against Catheter-Associated Thrombosis in Critically Ill Children: A Bayesian Phase 2b Randomized Clinical Trial. Critical Care Medicine 2020, 49: e235-e246. PMID: 33372745, PMCID: PMC7902342, DOI: 10.1097/ccm.0000000000004784.Peer-Reviewed Original ResearchConceptsCentral venous catheter-associated deep venous thrombosisCatheter-associated deep venous thrombosisDeep venous thrombosisUsual care armCentral venous cathetersVenous thrombosisClinical trialsEnoxaparin armCare armVenous cathetersEarly prophylaxisIll childrenThrombin generationPhase 2bCatheter-Associated ThrombosisInternational units/mLAnti-Xa levelsCritically Ill ChildrenRandomized clinical trialsEndogenous thrombin potentialRelevant bleedingUsual careTrial armsRisk ratioThrombin potentialPearls and Pitfalls in Pediatric Thyroid Imaging
Silva CT, Navarro OM. Pearls and Pitfalls in Pediatric Thyroid Imaging. Seminars In Ultrasound CT And MRI 2020, 41: 421-432. PMID: 32980089, DOI: 10.1053/j.sult.2020.05.007.Peer-Reviewed Original ResearchConceptsDiffuse thyroid enlargementThyroid enlargementCongenital hypothyroidismThyroid nodulesThyroid imagingPediatric age groupRole of imagingRisk of malignancyPermanent congenital hypothyroidismGraves' diseasePediatric populationHashimoto's diseaseNodular hyperplasiaPapillary carcinomaThyroid glandAccurate diagnosisAge groupsThyroid dysgenesisHypothyroidismDiseaseChildrenTeenage girlsImagingManagement recommendationsEnlargement
2019
Terminal Ileitis Presenting With a Spontaneously Reduced Ileocolic Intussusception Diagnosed by Point-of-Care Ultrasonography.
Riera A, Langhan M, Silva CT. Terminal Ileitis Presenting With a Spontaneously Reduced Ileocolic Intussusception Diagnosed by Point-of-Care Ultrasonography. Pediatric Emergency Care 2019, 36: e30-e32. PMID: 31433363, DOI: 10.1097/pec.0000000000001879.Peer-Reviewed Original ResearchMeSH KeywordsChild, PreschoolHumansIleal DiseasesIleitisIleumIntussusceptionMalePoint-of-Care SystemsRemission, SpontaneousConceptsIleocolic intussusceptionCare ultrasoundIschemic bowel injurySignificant inflammatory changesBowel injuryInitial workupInflammatory changesSurgical reductionTerminal ileitisTerminal ileumCare ultrasonographyRadiology ultrasoundIntussusceptionAcademic centersReduction attemptsSensitivity of studiesSpontaneous reductionTest characteristicsUltrasoundDiagnostic techniquesRadiologyIleitisUltrasonographyIleumInjury
2017
Abusive fracture incidence over three decades at a level 1 pediatric trauma center
Sharkey MS, Buesser KE, Gaither JR, Tate V, Cooperman DR, Moles RL, Silva CT, Ehrlich LJ, Leventhal JM. Abusive fracture incidence over three decades at a level 1 pediatric trauma center. Child Abuse & Neglect 2017, 76: 364-371. PMID: 29195174, DOI: 10.1016/j.chiabu.2017.11.008.Peer-Reviewed Original ResearchConceptsPediatric trauma centerLevel 1 pediatric trauma centerAbusive fracturesTrauma centerED visitsSingle pediatric trauma centerSame trauma centerSingle-institution reviewFracture incidenceInstitution reviewEmergency departmentIncidenceAgeChildrenConsensus ratingsRecent dataTime periodVisitsFracturesCurrent studyRecent time periodPeriodGeographic regionsCenterStudyInter-rater reliability of physical abuse determinations in young children with fractures
Buesser KE, Leventhal JM, Gaither JR, Tate V, Cooperman DR, Moles RL, Silva CT, Ehrlich LJ, Sharkey MS. Inter-rater reliability of physical abuse determinations in young children with fractures. Child Abuse & Neglect 2017, 72: 140-146. PMID: 28802910, DOI: 10.1016/j.chiabu.2017.08.001.Peer-Reviewed Original ResearchConceptsChild abuse pediatriciansModerate agreementPediatric emergency departmentMedical record dataYoung childrenAbusive injuriesEmergency departmentJoint ratingsClinical detailsInter-rater reliabilityPediatric radiologistsClinical scenariosMedical providersPairs of ratersPediatric orthopaedistsLevel of agreementOrthopaedistsRecord dataCliniciansGold standardIndependent ratingsRadiologistsChildrenExtent of agreementPhysiciansAssessment of a modified technique for air delivery during fluoroscopic-monitored pneumatic intussusception reduction
Jindal G, Graeber BL, Staib LH, Silva CT. Assessment of a modified technique for air delivery during fluoroscopic-monitored pneumatic intussusception reduction. Pediatric Radiology 2017, 47: 1594-1598. PMID: 28681232, DOI: 10.1007/s00247-017-3920-z.Peer-Reviewed Original ResearchConceptsAir delivery
2015
Diagnostic accuracy of point-of-care ultrasound for catheter-related thrombosis in children
Li S, Silva CT, Brudnicki AR, Baker KE, Tala JA, Pinto MG, Polikoff LA, Qin L, Faustino EV, Northeast Pediatric Critical Care Research Consortium. Diagnostic accuracy of point-of-care ultrasound for catheter-related thrombosis in children. Pediatric Radiology 2015, 46: 219-228. PMID: 26440129, PMCID: PMC4738063, DOI: 10.1007/s00247-015-3467-9.Peer-Reviewed Original ResearchMeSH KeywordsAge DistributionCausalityCentral Venous CathetersChildChild, PreschoolCohort StudiesConnecticutFemaleHumansInfantInfant, NewbornMalePoint-of-Care TestingPrevalenceReproducibility of ResultsRisk FactorsSensitivity and SpecificitySex DistributionUltrasonographyUpper Extremity Deep Vein ThrombosisConceptsCatheter-related thrombosisCare ultrasoundChance-corrected agreementIll childrenCare USCentral venous catheter-related thrombosisPediatric radiologistsDeep venous thrombosisCentral venous cathetersIntensive care unitVenous cathetersVenous thrombosisCare unitSubclavian veinThrombosisAccuracy of pointCatheterSensitivity of pointDiscordant readingsDiagnostic accuracyMulticenterUltrasoundRadiology departmentChildrenPhysiciansFactor VIII May Predict Catheter-Related Thrombosis in Critically Ill Children
Faustino EV, Li S, Silva CT, Pinto MG, Qin L, Tala JA, Rinder HM, Kupfer GM, Shapiro ED. Factor VIII May Predict Catheter-Related Thrombosis in Critically Ill Children. Pediatric Critical Care Medicine 2015, 16: 497-504. PMID: 25828784, PMCID: PMC4497863, DOI: 10.1097/pcc.0000000000000409.Peer-Reviewed Original ResearchConceptsCatheter-related thrombosisFactor VIII activityIncident thrombosisIll childrenVIII activityCentral venous catheter-related thrombosisDays of enrollmentProspective cohort studyCentral venous cathetersImportant clinical predictorsTertiary academic centerIU/dlPharmacologic thromboprophylaxisSurveillance ultrasonographyCohort studyVenous cathetersClinical predictorsThrombotic eventsOdds ratioSD increaseHigh riskThrombosisAcademic centersFactor VIIIYouden indexPrevalence of post‐thrombotic syndrome after cardiac catheterization
Luceri MJ, Tala JA, Weismann CG, Silva CT, Faustino EV. Prevalence of post‐thrombotic syndrome after cardiac catheterization. Pediatric Blood & Cancer 2015, 62: 1222-1227. PMID: 25663038, PMCID: PMC4433560, DOI: 10.1002/pbc.25438.Peer-Reviewed Original ResearchConceptsPost-thrombotic syndromeCardiac catheterizationFirst catheterizationCyanotic congenital heart diseaseManco-Johnson instrumentDeep venous thrombosisSurvival of childrenTime of enrollmentCongenital heart diseaseCross-sectional studyChronic complicationsCommon complicationMedian ageVenous thrombosisValvular insufficiencyFemoral veinHeart diseaseSignificant syndromeAntithrombotic agentsCatheterizationSyndromeDisease increasesThrombosisComplicationsChildren
2014
Blood glucose as a marker of venous thromboembolism in critically ill children
Tala JA, Silva CT, Pemira S, Vidal E, Faustino EV. Blood glucose as a marker of venous thromboembolism in critically ill children. Journal Of Thrombosis And Haemostasis 2014, 12: 891-896. PMID: 24708410, PMCID: PMC4055532, DOI: 10.1111/jth.12583.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAge FactorsBiomarkersBlood GlucoseChildChild, PreschoolChi-Square DistributionCritical IllnessFemaleHumansHyperglycemiaInfantIntensive Care Units, PediatricLogistic ModelsMaleOdds RatioPredictive Value of TestsPrognosisRetrospective StudiesRisk FactorsTime FactorsVenous ThromboembolismConceptsMaximum blood glucoseVenous thromboembolismBlood glucoseIll childrenOdds ratioPediatric intensive care unitRetrospective cohort studyCentral venous cathetersNon-diabetic childrenSeverity of illnessIntensive care unitLogistic regression modelsCohort studyVenous cathetersAntithrombotic useDiabetes mellitusPrimary outcomeCare unitHyperglycemic subjectsPrior diagnosisThromboembolismHyperglycemiaMechanical ventilatorPotential predictorsSubject characteristics
2012
Incidence and Acute Complications of Asymptomatic Central Venous Catheter–Related Deep Venous Thrombosis in Critically Ill Children
Faustino EV, Spinella PC, Li S, Pinto MG, Stoltz P, Tala J, Card ME, Northrup V, Baker KE, Goodman TR, Chen L, Silva CT. Incidence and Acute Complications of Asymptomatic Central Venous Catheter–Related Deep Venous Thrombosis in Critically Ill Children. The Journal Of Pediatrics 2012, 162: 387-391. PMID: 22883418, PMCID: PMC3575007, DOI: 10.1016/j.jpeds.2012.06.059.Peer-Reviewed Original ResearchConceptsCVC-related deep venous thrombosisDeep venous thrombosisCentral venous cathetersIntensive care unitAcute complicationsIll childrenVenous cathetersVenous thrombosisCare unitPediatric intensive care unitProspective cohort studyChronic complicationsHospital lengthCohort studyPatient demographicsPulmonary embolismCompression ultrasonographyMechanical ventilationHigher oddsCurrent incidenceColor DopplerComplicationsCVC characteristicsLarger studyThrombosisEarly assessment of the efficacy of digital infrared thermal imaging in pediatric extremity trauma
Silva CT, Naveed N, Bokhari S, Baker KE, Staib LH, Ibrahim SM, Muchantef K, Goodman TR. Early assessment of the efficacy of digital infrared thermal imaging in pediatric extremity trauma. Emergency Radiology 2012, 19: 203-209. PMID: 22362422, DOI: 10.1007/s10140-012-1027-2.Peer-Reviewed Original ResearchConceptsPediatric extremity traumaExtremity traumaSite of painPediatric emergency departmentSite of injuryPain sitesEmergency departmentLimb traumaContralateral limbExtremity radiographsFracture sitePatientsFurther evaluationRadiographsTraumaSame dayEarly assessmentWhole limbIntellectual disabilityLocal hyperthermiaYoung childrenDITIEfficacyLimbFractures
2010
CT characteristics of lung nodules present at diagnosis of extrapulmonary malignancy in children.
Silva CT, Amaral JG, Moineddin R, Doda W, Babyn PS. CT characteristics of lung nodules present at diagnosis of extrapulmonary malignancy in children. American Journal Of Roentgenology 2010, 194: 772-8. PMID: 20173158, DOI: 10.2214/ajr.09.2490.Peer-Reviewed Original ResearchConceptsExtrapulmonary malignanciesCT characteristicsLung nodulesBilateral lung nodulesOncology servicesChest CTPathology resultsCommon findingRetrospective analysisMalignant lesionsBenign lesionsMalignancyBiopsyPeripheral distributionCT attenuationSolid attenuationCTChildrenNodulesLesionsDiagnosisNodule featuresSubgroupsCT imagesVariety of patternsDo additional views improve the diagnostic performance of cervical spine radiography in pediatric trauma?
Silva CT, Doria AS, Traubici J, Moineddin R, Davila J, Shroff M. Do additional views improve the diagnostic performance of cervical spine radiography in pediatric trauma? American Journal Of Roentgenology 2010, 194: 500-8. PMID: 20093616, DOI: 10.2214/ajr.09.2837.Peer-Reviewed Original ResearchConceptsCervical spine abnormalitiesSubluxation/dislocationLateral view radiographsPediatric patientsPediatric traumaSpine abnormalitiesDiagnostic performanceView radiographsC1-C2 rotatory subluxationRadiographic viewsCervical spine radiographyCervical spine radiographsSpinous process fracturePediatric emergency departmentSensitivity of radiographyPerformance of radiographyLateral viewFracture dislocationOdontoid fracturesProcess fracturesEmergency departmentAcute traumaRadiographic abnormalitiesRotatory subluxationSpine radiography
2009
Computer-aided detection for the identification of pulmonary nodules in pediatric oncology patients: initial experience
Helm EJ, Silva CT, Roberts HC, Manson D, Seed MT, Amaral JG, Babyn PS. Computer-aided detection for the identification of pulmonary nodules in pediatric oncology patients: initial experience. Pediatric Radiology 2009, 39: 685-693. PMID: 19418048, DOI: 10.1007/s00247-009-1259-9.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAlgorithmsArtificial IntelligenceChildChild, PreschoolFemaleHumansLung NeoplasmsMaleObserver VariationPattern Recognition, AutomatedPilot ProjectsRadiographic Image EnhancementRadiographic Image Interpretation, Computer-AssistedReproducibility of ResultsSensitivity and SpecificitySolitary Pulmonary NoduleTomography, X-Ray ComputedConceptsPediatric oncology patientsPulmonary nodulesSensitivity of CADOncology patientsPediatric patientsPrimary tumorIRB approvalPediatric radiologistsMethodsCT scansInitial experiencePatientsLung nodulesNodule sizeNodulesAvailable CAD systemPerformance of CADRadiologistsComputer-aided detectionInitial findingsLow numberRadiologists' sensitivityObjectiveToTumorsSensitivity