2016
Extracellular matrix protein 1, a direct targeting molecule of parathyroid hormone‐related peptide, negatively regulates chondrogenesis and endochondral ossification via associating with progranulin growth factor
Kong L, Zhao Y, Tian Q, Feng J, Kobayashi T, Merregaert J, Liu C. Extracellular matrix protein 1, a direct targeting molecule of parathyroid hormone‐related peptide, negatively regulates chondrogenesis and endochondral ossification via associating with progranulin growth factor. The FASEB Journal 2016, 30: 2741-2754. PMID: 27075243, PMCID: PMC4970607, DOI: 10.1096/fj.201600261r.Peer-Reviewed Original ResearchConceptsExtracellular matrix protein 1Matrix protein 1Protein 1Endochondral ossificationCellular signaling pathwaysGrowth factorRegulation of chondrogenesisEndochondral bone formationUnrecognized regulatorChondrogenic growth factorsInteraction networksPTHrP regulationCartilage developmentSignaling pathwaysParathyroid hormone-related peptideTarget transgeneMatrix proteinsChondrocyte differentiationCellular interactionsHormone-related peptideChondrogenesisChondrocyte hypertrophyPTHrP actionOverexpressionPathway
2010
Interaction between cartilage oligomeric matrix protein and extracellular matrix protein 1 mediates endochondral bone growth
Kong L, Tian Q, Guo F, Mucignat M, Perris R, Sercu S, Merregaert J, Di Cesare P, Liu C. Interaction between cartilage oligomeric matrix protein and extracellular matrix protein 1 mediates endochondral bone growth. Matrix Biology 2010, 29: 276-286. PMID: 20138147, PMCID: PMC2862898, DOI: 10.1016/j.matbio.2010.01.007.Peer-Reviewed Original ResearchConceptsExtracellular matrix protein 1Matrix protein 1EGF domainsFunctional genetic screensProtein 1Endochondral bone growthGenetic screenEndochondral bone formationBiological functionsC-terminusMatrix proteinsMatrix mineralizationBiological significanceCartilage oligomeric matrix proteinOligomeric matrix proteinChondrocyte hypertrophyFirst evidenceBone growthInhibitionGrowthColocalizeBone formationDomainProteinInteraction