Homologous Recombination Conserves DNA Sequence Integrity Throughout the Cell Cycle in Embryonic Stem Cells
Serrano L, Liang L, Chang Y, Deng L, Maulion C, Nguyen S, Tischfield JA. Homologous Recombination Conserves DNA Sequence Integrity Throughout the Cell Cycle in Embryonic Stem Cells. Stem Cells And Development 2010, 20: 363-374. PMID: 20491544, PMCID: PMC3128761, DOI: 10.1089/scd.2010.0159.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell CycleCells, CulturedDeoxyuridineDNADNA Breaks, Double-StrandedDNA DamageDNA RepairEmbryonic Stem CellsFibroblastsHistonesMiceRad51 RecombinaseRecombination, GeneticConceptsDouble-strand breaksGerm cell lineageHomologous recombinationCell lineagesDifferentiated cellsMajor DSB repair pathwaysImportant genetic consequencesDNA sequence integrityHR-mediated repairDNA damage repair mechanismsFrequent homologous recombinationSpontaneous DNA damageDSB repair pathwaysStem cellsEmbryonic stem cellsDamage repair mechanismsGenome integrityGenetic consequencesGenomic integrityHomologous chromosomesUndesirable mutationsLow mutation frequencyChromosome sequencesRepair fociPathway choice