2015
The Determining Risk of Vascular Events by Apnea Monitoring (DREAM) study: design, rationale, and methods
Koo BB, Won C, Selim BJ, Qin L, Jeon S, Redeker NS, Bravata DM, Strohl KP, Concato J, Zinchuk AV, Yaggi HK. The Determining Risk of Vascular Events by Apnea Monitoring (DREAM) study: design, rationale, and methods. Sleep And Breathing 2015, 20: 893-900. PMID: 26642771, DOI: 10.1007/s11325-015-1254-3.Peer-Reviewed Original ResearchConceptsCardiovascular outcomesVascular eventsSleep architecturePrognostic modelRetrospective observational cohort studyMain primary outcomeMiddle-aged veteransTransient ischemic attackAcute coronary syndromeObservational cohort studyResultsThe study populationCongestive heart failureSleep-disordered breathingVA Patient Treatment FileVital Status filesPatient Treatment FileComputerized patient record systemVeterans Affairs centersPost-traumatic stress disorderIschemic attackCoronary syndromeCohort studySecondary outcomesComposite endpointGlycemic control
2012
Severe obstructive sleep apnea increases mortality in patients with ischemic heart disease and myocardial injury
Won CH, Chun HJ, Chandra SM, Sarinas PS, Chitkara RK, Heidenreich PA. Severe obstructive sleep apnea increases mortality in patients with ischemic heart disease and myocardial injury. Sleep And Breathing 2012, 17: 85-91. PMID: 22294346, DOI: 10.1007/s11325-012-0653-y.Peer-Reviewed Original ResearchMeSH KeywordsAgedAngina, UnstableBody Mass IndexCause of DeathCohort StudiesComorbidityContinuous Positive Airway PressureEchocardiographyFemaleFollow-Up StudiesHeart FailureHumansKaplan-Meier EstimateMaleMiddle AgedMyocardial InfarctionMyocardial IschemiaPatient CompliancePolysomnographyPrognosisRiskRisk FactorsSleep Apnea, ObstructiveSurvival AnalysisTroponin IConceptsSevere obstructive sleep apneaObstructive sleep apneaIschemic heart diseaseSleep apneaMyocardial injuryHeart diseaseOSA groupMild-moderate obstructive sleep apneaModerate obstructive sleep apneaPrevious myocardial injuryAdjusted hazard ratioRetrospective cohort studyConsecutive OSA patientsElevated troponin levelsSevere OSA groupRisk of deathDose-dependent impactCohort studyHazard ratioOSA patientsOSA severityTroponin levelsConclusionsThe severityRisk stratificationCardiac patients