2022
Prophage-encoded immune evasion factors are critical for Staphylococcus aureus host infection, switching, and adaptation
Chaguza C, Smith J, Bruce S, Gibson R, Martin I, Andam C. Prophage-encoded immune evasion factors are critical for Staphylococcus aureus host infection, switching, and adaptation. Cell Genomics 2022, 2: 100194. PMID: 36465278, PMCID: PMC9718559, DOI: 10.1016/j.xgen.2022.100194.Peer-Reviewed Original ResearchGenome-wide association studiesPopulation genomic studiesBacterial genetic variationMulti-host pathogensSpecific genetic lociGenomic studiesGenetic variationGenetic lociHost infectionAdditional lociAnimal hostsAssociation studiesImmune evasion factorsOverall heritabilityImmune evasion genesGenetic variantsAnimal isolatesLociHuman hostInfection of humansEvasion genesHostKey roleAdaptationIsolatesComparative Genomics of Disease and Carriage Serotype 1 Pneumococci
Chaguza C, Ebruke C, Senghore M, Lo S, Tientcheu P, Gladstone R, Tonkin-Hill G, Cornick J, Yang M, Worwui A, McGee L, Breiman R, Klugman K, Kadioglu A, Everett D, Mackenzie G, Croucher N, Roca A, Kwambana-Adams B, Antonio M, Bentley S. Comparative Genomics of Disease and Carriage Serotype 1 Pneumococci. Genome Biology And Evolution 2022, 14: evac052. PMID: 35439297, PMCID: PMC9048925, DOI: 10.1093/gbe/evac052.Peer-Reviewed Original ResearchConceptsGenomic variationGenome-wide association studiesComparative genomicsGenetic variationLineage distributionAssociation studiesPhenotypic variabilityPathogen surveillanceSystemic tissuesIsolatesSerotype 1GenomicsLineagesGeneticsMinimal effectVariationInvasivenessSerotype 1 pneumococciIsolationInvasive disease
2015
Comparative Genomic Analysis of Meningitis- and Bacteremia-Causing Pneumococci Identifies a Common Core Genome
Kulohoma BW, Cornick JE, Chaguza C, Yalcin F, Harris SR, Gray KJ, Kiran AM, Molyneux E, French N, Parkhill J, Faragher BE, Everett DB, Bentley SD, Heyderman RS. Comparative Genomic Analysis of Meningitis- and Bacteremia-Causing Pneumococci Identifies a Common Core Genome. Infection And Immunity 2015, 83: 4165-4173. PMID: 26259813, PMCID: PMC4567637, DOI: 10.1128/iai.00814-15.Peer-Reviewed Original ResearchConceptsBloodstream infectionsSterile sitesPneumococcal population structureDisease manifestationsMeningitisVaccine candidatesS. pneumoniaeStreptococcus pneumoniaeNasopharyngeal commensalPneumococciVirulence factorsWhole-genome sequencingInfectionPneumoniaeVirulence behaviorPresence/absenceIsolatesMeninges