Effect of intra-partum azithromycin on the development of the infant nasopharyngeal microbiota: A post hoc analysis of a double-blind randomized trial
Sanyang B, de Silva T, Kanteh A, Bojang A, Manneh J, de Steenhuijsen Piters W, Peno C, Bogaert D, Sesay A, Roca A. Effect of intra-partum azithromycin on the development of the infant nasopharyngeal microbiota: A post hoc analysis of a double-blind randomized trial. EBioMedicine 2022, 83: 104227. PMID: 35988464, PMCID: PMC9420482, DOI: 10.1016/j.ebiom.2022.104227.Peer-Reviewed Original ResearchMeSH KeywordsAnti-Bacterial AgentsAzithromycinBacteriaChildDouble-Blind MethodFemaleHumansInfantInfant, NewbornMicrobiotaRNA, Ribosomal, 16SSepsisConceptsNasopharyngeal microbiotaDay 6Neonatal periodDouble-blind randomized placebo-controlled clinical trialRandomized placebo-controlled clinical trialPlacebo-controlled clinical trialEarly antibiotic exposureMonths of ageMedical Research CouncilOverall microbiota compositionOral azithromycinPlacebo armNasopharyngeal carriageHealthy infantsModest overall effectNeonatal deathNasopharyngeal samplesMicrobiota perturbationsClinical trialsLeading causeAntibiotic exposureBacterial carriageShort-term alterationsMicrobiota compositionAzithromycin