2022
Effect of intra-partum azithromycin on the development of the infant nasopharyngeal microbiota: A post hoc analysis of a double-blind randomized trial
Sanyang B, de Silva T, Kanteh A, Bojang A, Manneh J, de Steenhuijsen Piters W, Peno C, Bogaert D, Sesay A, Roca A. Effect of intra-partum azithromycin on the development of the infant nasopharyngeal microbiota: A post hoc analysis of a double-blind randomized trial. EBioMedicine 2022, 83: 104227. PMID: 35988464, PMCID: PMC9420482, DOI: 10.1016/j.ebiom.2022.104227.Peer-Reviewed Original ResearchConceptsNasopharyngeal microbiotaDay 6Neonatal periodDouble-blind randomized placebo-controlled clinical trialRandomized placebo-controlled clinical trialPlacebo-controlled clinical trialEarly antibiotic exposureMonths of ageMedical Research CouncilOverall microbiota compositionOral azithromycinPlacebo armNasopharyngeal carriageHealthy infantsModest overall effectNeonatal deathNasopharyngeal samplesMicrobiota perturbationsClinical trialsLeading causeAntibiotic exposureBacterial carriageShort-term alterationsMicrobiota compositionAzithromycin
2020
Niche- and Gender-Dependent Immune Reactions in Relation to the Microbiota Profile in Pediatric Patients with Otitis Media with Effusion
Enoksson F, Rodriguez A, Peno C, Lopez C, Tjernström F, Bogaert D, Hakansson A, Bergenfelz C. Niche- and Gender-Dependent Immune Reactions in Relation to the Microbiota Profile in Pediatric Patients with Otitis Media with Effusion. Infection And Immunity 2020, 88: e00147-20. PMID: 32661126, PMCID: PMC7504947, DOI: 10.1128/iai.00147-20.Peer-Reviewed Original ResearchConceptsMiddle earInflammatory mediatorsOtitis mediaImmune responseChronic low-grade inflammationMiddle ear effusion samplesLow-grade inflammationSpecific inflammatory mediatorsAnti-inflammatory mediatorsAnti-inflammatory profileCommon inflammatory diseaseSigns of infectionHost immune responsePotential pathogenic mechanismsInflammation patternsMale patientsPediatric patientsProinflammatory mediatorsFemale patientsPrecise pathogenesisProinflammatory profileInflammatory diseasesT lymphocytesImmune reactionsPathogenic mechanisms