2019
Early Signals of Vaccine-driven Perturbation Seen in Pneumococcal Carriage Population Genomic Data
Chaguza C, Heinsbroek E, Gladstone RA, Tafatatha T, Alaerts M, Peno C, Cornick JE, Musicha P, Bar-Zeev N, Kamng’ona A, Kadioglu A, McGee L, Hanage WP, Breiman RF, Heyderman RS, French N, Everett DB, Bentley SD. Early Signals of Vaccine-driven Perturbation Seen in Pneumococcal Carriage Population Genomic Data. Clinical Infectious Diseases 2019, 70: 1294-1303. PMID: 31094423, PMCID: PMC7768739, DOI: 10.1093/cid/ciz404.Peer-Reviewed Original ResearchConceptsYears of ageVaccine serotypesWhole-genome sequencingHigh disease burdenAntibiotic resistanceLow-income settingsPCV introductionReplacement serotypesVT serotypesPneumococcal diseaseNonvaccine serotypesCarriage rateDisease burdenPneumococcal isolatesSerotype dynamicsContinued surveillancePCV effectsAge groupsSerotypesSerotype diversityAgeVaccineResistant lineagesPCVChildren
2017
Genomic landscape of extended-spectrum β-lactamase resistance in Escherichia coli from an urban African setting
Musicha P, Feasey NA, Cain AK, Kallonen T, Chaguza C, Peno C, Khonga M, Thompson S, Gray KJ, Mather AE, Heyderman RS, Everett DB, Thomson NR, Msefula CL. Genomic landscape of extended-spectrum β-lactamase resistance in Escherichia coli from an urban African setting. Journal Of Antimicrobial Chemotherapy 2017, 72: 1602-1609. PMID: 28333330, PMCID: PMC5437524, DOI: 10.1093/jac/dkx058.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultBeta-Lactam ResistanceBeta-LactamasesChildChild, PreschoolChloramphenicolDrug Resistance, Multiple, BacterialEscherichia coliEscherichia coli InfectionsFemaleGenes, BacterialGenetic VariationGenomicsHumansMalawiMaleMicrobial Sensitivity TestsMultilocus Sequence TypingPhylogenyUrban PopulationYoung AdultConceptsAntimicrobial resistanceExtended spectrum β-lactamase resistanceEscherichia coli infectionResource-rich settingsUrban African settingCommon ESBL geneLow-income settingsPhenotypic resistance profilesΒ-lactamase resistanceColi infectionESBL resistanceGlobal epidemiologyFluoroquinolone resistanceQueen's HospitalBla CTXESBL genesMolecular epidemiologyResistance profilesMolecular patternsAfrican settingClinical sourcesHospitalE. coliEpidemiologyST131