2021
Genomic investigation of a suspected Klebsiella pneumoniae outbreak in a neonatal care unit in sub-Saharan Africa
Cornick J, Musicha P, Peno C, Seager E, Tam P, Bilima S, Bennett A, Kennedy N, Feasey N, Heinz E, Cain A. Genomic investigation of a suspected Klebsiella pneumoniae outbreak in a neonatal care unit in sub-Saharan Africa. Microbial Genomics 2021, 7: 000703. PMID: 34793293, PMCID: PMC8743538, DOI: 10.1099/mgen.0.000703.Peer-Reviewed Original ResearchConceptsStrain sequence typesBloodstream infectionsSpecial Care Neonatal UnitNeonatal care unitImportant hospital pathogensKlebsiella pneumoniae outbreakLarge public hospitalCare unitNeonatal unitPediatric wardNeonatal wardHospital outbreaksTreat infectionsHospital pathogensPublic hospitalsPlasmid typesHospitalWhole-genome sequencingInfectionSequence typesWardsYear periodSaharan AfricaOutbreakLikely cause
2017
Genomic landscape of extended-spectrum β-lactamase resistance in Escherichia coli from an urban African setting
Musicha P, Feasey NA, Cain AK, Kallonen T, Chaguza C, Peno C, Khonga M, Thompson S, Gray KJ, Mather AE, Heyderman RS, Everett DB, Thomson NR, Msefula CL. Genomic landscape of extended-spectrum β-lactamase resistance in Escherichia coli from an urban African setting. Journal Of Antimicrobial Chemotherapy 2017, 72: 1602-1609. PMID: 28333330, PMCID: PMC5437524, DOI: 10.1093/jac/dkx058.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultBeta-Lactam ResistanceBeta-LactamasesChildChild, PreschoolChloramphenicolDrug Resistance, Multiple, BacterialEscherichia coliEscherichia coli InfectionsFemaleGenes, BacterialGenetic VariationGenomicsHumansMalawiMaleMicrobial Sensitivity TestsMultilocus Sequence TypingPhylogenyUrban PopulationYoung AdultConceptsAntimicrobial resistanceExtended spectrum β-lactamase resistanceEscherichia coli infectionResource-rich settingsUrban African settingCommon ESBL geneLow-income settingsPhenotypic resistance profilesΒ-lactamase resistanceColi infectionESBL resistanceGlobal epidemiologyFluoroquinolone resistanceQueen's HospitalBla CTXESBL genesMolecular epidemiologyResistance profilesMolecular patternsAfrican settingClinical sourcesHospitalE. coliEpidemiologyST131