2022
Cross-vender, cross-tracer, and cross-protocol deep transfer learning for attenuation map generation of cardiac SPECT
Chen X, Pretorius P, Zhou B, Liu H, Johnson K, Liu YH, King MA, Liu C. Cross-vender, cross-tracer, and cross-protocol deep transfer learning for attenuation map generation of cardiac SPECT. Journal Of Nuclear Cardiology 2022, 29: 3379-3391. PMID: 35474443, PMCID: PMC11407548, DOI: 10.1007/s12350-022-02978-7.Peer-Reviewed Original Research
2021
Generation of parametric Ki images for FDG PET using two 5‐min scans
Wu J, Liu H, Ye Q, Gallezot J, Naganawa M, Miao T, Lu Y, Chen M, Esserman DA, Kyriakides TC, Carson RE, Liu C. Generation of parametric Ki images for FDG PET using two 5‐min scans. Medical Physics 2021, 48: 5219-5231. PMID: 34287939, DOI: 10.1002/mp.15113.Peer-Reviewed Original ResearchMeSH KeywordsAlgorithmsFluorodeoxyglucose F18HumansPositron-Emission TomographyRadiopharmaceuticalsWhole Body ImagingConceptsPopulation-based input functionDynamic FDG-PET scansFDG-PET scansFDG-PETSUV changesPET scansClinical practiceSolid lung nodulesClinical usefulnessLate scansBone marrowRegion of interestLung nodulesInput functionScansPatlak analysisKi imagesMin/T-testCorrelation coefficientTumorsSubjectsNodulesDynamic imagingPET
2018
Improved discrimination between benign and malignant LDCT screening-detected lung nodules with dynamic over static 18F-FDG PET as a function of injected dose
Ye Q, Wu J, Lu Y, Naganawa M, Gallezot JD, Ma T, Liu Y, Tanoue L, Detterbeck F, Blasberg J, Chen MK, Casey M, Carson RE, Liu C. Improved discrimination between benign and malignant LDCT screening-detected lung nodules with dynamic over static 18F-FDG PET as a function of injected dose. Physics In Medicine And Biology 2018, 63: 175015. PMID: 30095083, PMCID: PMC6158045, DOI: 10.1088/1361-6560/aad97f.Peer-Reviewed Original ResearchConceptsPopulation-based input functionStandardized uptake valueImage-derived input functionLung nodulesClinical trialsTime-activity curvesLow-dose computed tomography (LDCT) screeningLung cancer mortality ratesIndeterminate lung nodulesComputed Tomography ScreeningF-FDG PETCancer mortality ratesStatic PET acquisitionVirtual clinical trialsScan durationTomography screeningFDG injectionPET scansMortality rateUptake valueAccurate diagnosisMalignant lung nodulesROC analysisPatient dataMalignant nodules
2016
Quantitative Analysis of Dynamic 123I-mIBG SPECT Imaging Data in Healthy Humans with a Population-Based Metabolite Correction Method
Wu J, Lin SF, Gallezot JD, Chan C, Prasad R, Thorn S, Stacy MR, Huang Y, Zonouz TH, Liu YH, Lampert RJ, Carson RE, Sinusas AJ, Liu C. Quantitative Analysis of Dynamic 123I-mIBG SPECT Imaging Data in Healthy Humans with a Population-Based Metabolite Correction Method. Journal Of Nuclear Medicine 2016, 57: 1226-1232. PMID: 27081169, DOI: 10.2967/jnumed.115.171710.Peer-Reviewed Original Research3-IodobenzylguanidineAdultAgedAlgorithmsArtifactsComputer SimulationFemaleHeartHumansImage EnhancementImage Interpretation, Computer-AssistedMaleMiddle AgedModels, CardiovascularModels, StatisticalMyocardiumRadiopharmaceuticalsReproducibility of ResultsSensitivity and SpecificityTissue DistributionTomography, Emission-Computed, Single-PhotonEvent-by-Event Continuous Respiratory Motion Correction for Dynamic PET Imaging
Yu Y, Chan C, Ma T, Liu Y, Gallezot JD, Naganawa M, Kelada OJ, Germino M, Sinusas AJ, Carson RE, Liu C. Event-by-Event Continuous Respiratory Motion Correction for Dynamic PET Imaging. Journal Of Nuclear Medicine 2016, 57: 1084-1090. PMID: 26912437, DOI: 10.2967/jnumed.115.167676.Peer-Reviewed Original Research
2015
Scatter and crosstalk corrections for 99mTc/123I dual‐radionuclide imaging using a CZT SPECT system with pinhole collimators
Fan P, Hutton BF, Holstensson M, Ljungberg M, Pretorius P, Prasad R, Ma T, Liu Y, Wang S, Thorn SL, Stacy MR, Sinusas AJ, Liu C. Scatter and crosstalk corrections for 99mTc/123I dual‐radionuclide imaging using a CZT SPECT system with pinhole collimators. Medical Physics 2015, 42: 6895-6911. PMID: 26632046, DOI: 10.1118/1.4934830.Peer-Reviewed Original ResearchConceptsDual-radionuclide imagingCrosstalk correction methodTEW methodLine source experimentDefect contrastSource experimentsMonte Carlo simulationsIncomplete charge collectionCadmium zinc telluride detectorsLow-energy tailImaging systemCarlo simulationsPinhole collimatorCardiac SPECT systemEnergy tailDetector effectsEnergy spectrumPoint source measurementsSPECT systemCZT detectorsTriple energy window (TEW) methodScatter modelDedicated cardiac SPECT systemsCorrection methodCrosstalk correctionAnatomical-based partial volume correction for low-dose dedicated cardiac SPECT/CT
Liu H, Chan C, Grobshtein Y, Ma T, Liu Y, Wang S, Stacy MR, Sinusas AJ, Liu C. Anatomical-based partial volume correction for low-dose dedicated cardiac SPECT/CT. Physics In Medicine And Biology 2015, 60: 6751-6773. PMID: 26296043, PMCID: PMC4747118, DOI: 10.1088/0031-9155/60/17/6751.Peer-Reviewed Original ResearchAnimalsBlood VolumeCardiac-Gated Single-Photon Emission Computer-Assisted TomographyDogsDose-Response Relationship, RadiationErythrocytesHeartHumansImage EnhancementImage Interpretation, Computer-AssistedModels, CardiovascularMyocardial Perfusion ImagingOrganophosphorus CompoundsOrganotechnetium CompoundsPhantoms, ImagingRadiopharmaceuticalsReproducibility of ResultsSwineTissue DistributionTomography, X-Ray Computed