2024
Decidual Cells Block Inflammation-Mediated Inhibition of 15-Hydroxyprostaglandin Dehydrogenase in Trophoblasts
de Assis V, Kayisli U, Ozmen A, Semerci N, Totary-Jain H, Pakasticali N, Halade G, Lockwood C, Guzeloglu-Kayisli O. Decidual Cells Block Inflammation-Mediated Inhibition of 15-Hydroxyprostaglandin Dehydrogenase in Trophoblasts. American Journal Of Pathology 2024, 194: 1724-1736. PMID: 38879084, DOI: 10.1016/j.ajpath.2024.05.005.Peer-Reviewed Original ResearchConditioned medium supernatantTerm decidual cellsDecidual cellsExtravillous trophoblastHPGD expressionGestational age-matched controlsHuman trophoblast stem cellsFetal membrane ruptureMaternal-fetal interfaceTrophoblast stem cellsAge-matched controlsDecidua parietalisCervical ripeningUterine quiescencePreterm birthUterine contractionsAnchoring villiPrimary trophoblastsParacrine mechanismsParacrine inhibitionPregnancy maintenanceIL-1BInactivate prostaglandinsStem cellsProstaglandin
2023
Pathogenesis and Prediction of Preterm Delivery
Kendle A, Buhimschi C, Lockwood C. Pathogenesis and Prediction of Preterm Delivery. 2023, 344-360. DOI: 10.1002/9781119636540.ch40.Peer-Reviewed Original ResearchPreterm birthPR expressionPlacental corticotropin-releasing hormonePrediction of PTBAdrenal (HPA) axis pathwayCorticotropin-releasing hormoneToll-like receptorsProtease-activated receptorsPreterm deliveryProgesterone receptor inhibitorsDecidual hemorrhageInflammatory cascadeProinflammatory cytokinesInflammatory chemokinesProgesterone activityInterleukin-1βSonographic markersReceptor inhibitorsCortisol releaseInflammation pathwaysMatrix metalloproteinasesAxis pathwayPremature activationBiochemical remodelingProgressive withdrawal