2009
Complex N-Linked Glycans on Asn-89 of Kaposi Sarcoma Herpes Virus-encoded Interleukin-6 Mediate Optimal Function by Affecting Cytokine Protein Conformation*
Dela Cruz CS, Viswanathan SR, El-Guindy AS, Shedd D, Miller G. Complex N-Linked Glycans on Asn-89 of Kaposi Sarcoma Herpes Virus-encoded Interleukin-6 Mediate Optimal Function by Affecting Cytokine Protein Conformation*. Journal Of Biological Chemistry 2009, 284: 29269-29282. PMID: 19690161, PMCID: PMC2785557, DOI: 10.1074/jbc.m109.039115.Peer-Reviewed Original ResearchConceptsVIL-6IL-6RalphaProtein conformationComplex glycansHuman cellular homologueSimilar biological functionsKaposi's sarcoma-associated herpesvirusAsn-89Conformation-specific antibodiesCellular homologueCytokine functionSarcoma-associated herpesvirusProtein functionHigh-mannose glycansBiological functionsViral cytokineDigestion assaysMannose glycansGp130Optimal functionGlycansGlycosylationHuman IL-6HuIL-6Intracellular production
2004
N-linked Glycosylation Is Required for Optimal Function of Kaposi's Sarcoma Herpesvirus–encoded, but Not Cellular, Interleukin 6
Dela Cruz CS, Lee Y, Viswanathan SR, El-Guindy AS, Gerlach J, Nikiforow S, Shedd D, Gradoville L, Miller G. N-linked Glycosylation Is Required for Optimal Function of Kaposi's Sarcoma Herpesvirus–encoded, but Not Cellular, Interleukin 6. Journal Of Experimental Medicine 2004, 199: 503-514. PMID: 14970177, PMCID: PMC2211829, DOI: 10.1084/jem.20031205.Peer-Reviewed Original ResearchConceptsVIL-6Janus tyrosine kinaseSimilar biological functionsActivator of transcriptionGp130 receptor subunitCellular IL-6Distinct functional rolesFunctional homologueBiological functionsSignal transducerTyrosine kinaseFunctional roleKaposi's sarcoma herpesvirusCell proliferation bioassayGlycosylationCell proliferationReceptor subunitsGp130B cell proliferationN89PathwayOptimal functionTranscriptionHomologuesKinase