2021
In vivo imaging of mGlu5 receptor expression in humans with Fragile X Syndrome towards development of a potential biomarker
Mody M, Petibon Y, Han P, Kuruppu D, Ma C, Yokell D, Neelamegam R, Normandin M, Fakhri G, Brownell A. In vivo imaging of mGlu5 receptor expression in humans with Fragile X Syndrome towards development of a potential biomarker. Scientific Reports 2021, 11: 15897. PMID: 34354107, PMCID: PMC8342610, DOI: 10.1038/s41598-021-94967-y.Peer-Reviewed Original ResearchConceptsFragile X syndromeFragile X mental retardation proteinX syndromeLoss of fragile X mental retardation proteinMGlu5 receptor expressionMetabotropic glutamate subtype 5 receptorsDrug occupancy studiesSignificant group differencesFragile X mental retardationHealthy controlsAnterior cingulateMGluR5 availabilityVisuospatial processingMGlu5 receptorsOlfactory cortexBrain areasGroup differencesRetardation proteinGlutamate signalingImages of maleNeurodevelopmental disordersExcessive glutamate signalingGender-matched controlsDisordersMGluR5Quantification of Myocardial Mitochondrial Membrane Potential Using PET
Pelletier-Galarneau M, Detmer F, Petibon Y, Normandin M, Ma C, Alpert N, El Fakhri G. Quantification of Myocardial Mitochondrial Membrane Potential Using PET. Current Cardiology Reports 2021, 23: 70. PMID: 33970353, PMCID: PMC8443083, DOI: 10.1007/s11886-021-01500-8.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsHumansMembrane Potential, MitochondrialMyocardiumOrganophosphorus CompoundsPositron-Emission Tomography
2020
Motion correction for PET data using subspace-based real-time MR imaging in simultaneous PET/MR
Marin T, Djebra Y, Han P, Chemli Y, Bloch I, Fakhri G, Ouyang J, Petibon Y, Ma C. Motion correction for PET data using subspace-based real-time MR imaging in simultaneous PET/MR. Physics In Medicine And Biology 2020, 65: 235022. PMID: 33263317, PMCID: PMC7985095, DOI: 10.1088/1361-6560/abb31d.Peer-Reviewed Original ResearchMeSH KeywordsArtifactsHumansImage Processing, Computer-AssistedMagnetic Resonance ImagingMovementMultimodal ImagingPositron-Emission TomographyTime FactorsConceptsPositron emission tomography reconstructionMotion-corrected PET reconstructionsPET reconstructionMotion-corrected PET imagesIrregular respiratory motionMotion fieldMotion correction methodMotion correction approachIrregular motion patternsUndersampled k-space dataImage quality of positron emission tomographyQuality of positron emission tomographyMotion patternsLow-rank characteristicsRespiratory motionContrast-to-noise ratioEstimated motion fieldSurrogate signalsMotion correctionK-space dataImage qualityReal-time MR imagingSimultaneous PET/MRMotion artifact reductionPET/MR scannersAttenuation correction using deep Learning and integrated UTE/multi-echo Dixon sequence: evaluation in amyloid and tau PET imaging
Gong K, Han P, Johnson K, El Fakhri G, Ma C, Li Q. Attenuation correction using deep Learning and integrated UTE/multi-echo Dixon sequence: evaluation in amyloid and tau PET imaging. European Journal Of Nuclear Medicine And Molecular Imaging 2020, 48: 1351-1361. PMID: 33108475, PMCID: PMC8411350, DOI: 10.1007/s00259-020-05061-w.Peer-Reviewed Original ResearchMeSH KeywordsDeep LearningHumansImage Processing, Computer-AssistedMagnetic Resonance ImagingMultimodal ImagingPositron-Emission TomographyTomography, X-Ray ComputedConceptsAttenuation correctionResultsThe Dice coefficientPseudo-CT imagesMR-based AC methodsAccurate ACAC accuracyPET imagingDice coefficientQuantitative accuracyAtlas methodAC methodGradient echoNear verticesTau imagingTau PET imagingAlzheimer's diseaseUltrashortCorrectionTau pathologyRapid acquisitionDeep learning methodsMonitoring of Alzheimer’s diseasePET/MRAmyloidEvaluation of the potassium channel tracer [18F]3F4AP in rhesus macaques
Guehl N, Ramos-Torres K, Linnman C, Moon S, Dhaynaut M, Wilks M, Han P, Ma C, Neelamegam R, Zhou Y, Popko B, Correia J, Reich D, Fakhri G, Herscovitch P, Normandin M, Brugarolas P. Evaluation of the potassium channel tracer [18F]3F4AP in rhesus macaques. Cerebrovascular And Brain Metabolism Reviews 2020, 41: 1721-1733. PMID: 33090071, PMCID: PMC8221756, DOI: 10.1177/0271678x20963404.Peer-Reviewed Original ResearchMeSH KeywordsAminopyridinesAnimalsBrain InjuriesFluorine RadioisotopesMacaca mulattaMalePositron-Emission TomographyPotassium ChannelsRadioactive TracersRadiopharmaceuticalsConceptsFocal brain injuryMyelin repair therapyContributions of demyelinationDrivers of disabilityImaging demyelinationBrain injuryMeasurements of molecular changesTool's sensitivity to changesLower myelin contentDemyelinating lesionsNeuronal conductionImpaired conductionDemyelinationBrain penetrationGold standardRhesus macaquesInjured areaMultiple sclerosisMolecular changesMyelin sheathNeurological diseasesHigh metabolic stabilityMRI methodsMRIInjuryIn vivo quantitative mapping of human mitochondrial cardiac membrane potential: a feasibility study
Pelletier-Galarneau M, Petibon Y, Ma C, Han P, Kim S, Detmer F, Yokell D, Guehl N, Normandin M, El Fakhri G, Alpert N. In vivo quantitative mapping of human mitochondrial cardiac membrane potential: a feasibility study. European Journal Of Nuclear Medicine And Molecular Imaging 2020, 48: 414-420. PMID: 32719915, PMCID: PMC7839097, DOI: 10.1007/s00259-020-04878-9.Peer-Reviewed Original ResearchMeSH KeywordsFeasibility StudiesHumansMembrane PotentialsMyocardiumPositron-Emission TomographyTomography, X-Ray ComputedConceptsMembrane potentialBolus injectionHealthy subjectsHematocrit levelsSerial venous blood samplesT1 mapping imagesVenous blood samplesExtracellular space fractionMethodsThirteen healthy subjectsDynamic PET acquisitionCellular membrane potentialGadolinium injectionPrognostic informationVentricular arrhythmiasHeart failureMyocardial hypertrophyMitochondrial membrane potentialCardiac diseaseIn vitro assessmentTherapy monitoringBlood concentrationsPET acquisitionImaging protocolBlood samplesPlasma tracer concentrationMR‐based PET attenuation correction using a combined ultrashort echo time/multi‐echo Dixon acquisition
Han P, Horng D, Gong K, Petibon Y, Kim K, Li Q, Johnson K, Fakhri G, Ouyang J, Ma C. MR‐based PET attenuation correction using a combined ultrashort echo time/multi‐echo Dixon acquisition. Medical Physics 2020, 47: 3064-3077. PMID: 32279317, PMCID: PMC7375929, DOI: 10.1002/mp.14180.Peer-Reviewed Original ResearchMeSH KeywordsHumansImage Processing, Computer-AssistedMagnetic Resonance ImagingPhantoms, ImagingPositron-Emission TomographyTomography, X-Ray ComputedConceptsLinear attenuation coefficientPositron emission tomography attenuation correctionPhysical compartmental modelAttenuation correctionShort T<sub>2</sub> componentPET attenuation correctionRadial k-space trajectoryMagnetic resonance (MR)-based methodK-space trajectoriesRadial trajectoryK-spaceAttenuation coefficientDixon acquisitionsPositron emission tomographyWhole white matterMuting methodImage reconstructionImaging speedMR signalMRAC methodPositron emission tomography imagingCorrectionGray matter regionsPhantomMatter regions
2019
Body motion detection and correction in cardiac PET: Phantom and human studies
Sun T, Petibon Y, Han P, Ma C, Kim S, Alpert N, Fakhri G, Ouyang J. Body motion detection and correction in cardiac PET: Phantom and human studies. Medical Physics 2019, 46: 4898-4906. PMID: 31508827, PMCID: PMC6842053, DOI: 10.1002/mp.13815.Peer-Reviewed Original ResearchMeSH KeywordsArtifactsFluorodeoxyglucose F18HeartHumansImage Processing, Computer-AssistedMovementPhantoms, ImagingPositron-Emission TomographyConceptsList-mode dataMotion-compensated image reconstructionMotion correctionCenter of massPET list-mode dataMotion correction methodMotion detectionMotion estimationImage reconstructionPatient body motionDegrade image qualityNonrigid registrationImage qualityMotion transformationCoincident distributionBody motion detectionCardiac positron emission tomographyBack-projection techniqueCovariance matrixImage volumesBody motionPositron emission tomographyBack-projectionReference framePhantomMR-based cardiac and respiratory motion correction of PET: application to static and dynamic cardiac 18F-FDG imaging
Petibon Y, Sun T, Han P, Ma C, Fakhri G, Ouyang J. MR-based cardiac and respiratory motion correction of PET: application to static and dynamic cardiac 18F-FDG imaging. Physics In Medicine And Biology 2019, 64: 195009. PMID: 31394518, PMCID: PMC7007962, DOI: 10.1088/1361-6560/ab39c2.Peer-Reviewed Original ResearchConceptsMR-based motion correctionRespiratory motion correctionMotion correctionImproved spatial resolutionReconstructed activity concentrationCardiac PET dataSpatial resolutionCoincidence eventsMR-basedPET imagingContrast-to-noise ratioCardiac PET imagingRespiratory phasesMC dataImprove image qualityMR acquisitionQuantitative accuracyCardiac PETPET dataActivity concentrationsMyocardium wallF-FDG PETDynamics studiesImage qualityMotion artifacts
2018
Quantitative in vivo mapping of myocardial mitochondrial membrane potential
Alpert N, Guehl N, Ptaszek L, Pelletier-Galarneau M, Ruskin J, Mansour M, Wooten D, Ma C, Takahashi K, Zhou Y, Shoup T, Normandin M, Fakhri G. Quantitative in vivo mapping of myocardial mitochondrial membrane potential. PLOS ONE 2018, 13: e0190968. PMID: 29338024, PMCID: PMC5770041, DOI: 10.1371/journal.pone.0190968.Peer-Reviewed Original Research