2018
Metabolic syndrome identifies normal weight insulin-resistant stroke patients at risk for recurrent vascular disease
Dearborn JL, Viscoli CM, Inzucchi SE, Young LH, Kernan WN. Metabolic syndrome identifies normal weight insulin-resistant stroke patients at risk for recurrent vascular disease. International Journal Of Stroke 2018, 14: 639-645. PMID: 30507360, DOI: 10.1177/1747493018816425.Peer-Reviewed Original ResearchConceptsNormal weight patientsMetabolic syndromeMyocardial infarctionWeight patientsCause mortalityInsulin resistanceHigh riskInsulin Resistance InterventionRecent ischemic strokeRecurrent vascular diseaseNon-diabetic patientsTransient ischemic attackAdverse cardiovascular outcomesMajor comorbid conditionsIschemic attackCardiovascular outcomesObesity paradoxIschemic strokeNormal BMIObese patientsStroke populationBetter prognosisComorbid conditionsNormal weightStroke patients
2016
A Diagnostic Score for Insulin Resistance in Nondiabetic Patients with Ischemic Stroke or Transient Ischemic Attack
Xu J, Viscoli CM, Ford GA, Gorman M, Kernan WN, Investigators I. A Diagnostic Score for Insulin Resistance in Nondiabetic Patients with Ischemic Stroke or Transient Ischemic Attack. Journal Of Stroke And Cerebrovascular Diseases 2016, 25: 1705-1712. PMID: 27080156, PMCID: PMC5749402, DOI: 10.1016/j.jstrokecerebrovasdis.2016.03.043.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedArea Under CurveBiomarkersBlood GlucoseBlood PressureBody Mass IndexBrain IschemiaFemaleGlucose Metabolism DisordersHumansInsulinInsulin ResistanceIschemic Attack, TransientLipoproteins, HDLMaleMiddle AgedMultivariate AnalysisObesity, AbdominalPredictive Value of TestsRandomized Controlled Trials as TopicReproducibility of ResultsRisk FactorsROC CurveSex FactorsStrokeTriglyceridesWaist-Hip RatioConceptsTransient ischemic attackBody mass indexInsulin resistanceMultivariable regression analysisNondiabetic patientsIschemic strokeIschemic attackAbdominal obesityValidation cohortTriglyceride/high-density lipoprotein ratioHigh-density lipoprotein ratioRecent ischemic strokeHomeostasis model assessmentSystolic blood pressureLaboratory test valuesRegression analysisElevated waistHOMA-IRLipoprotein ratioBlood pressureMass indexMultivariable analysisStroke patientsHip ratioMale gender